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- W3048215082 abstract "Abstract Neonatal maternal separation (NMS), as an early-life stress (ELS), is a risk factor to develop emotional disorders. However, the exact mechanisms remain to be defined. In the present study, we investigated the mechanisms involved in developing emotional disorders caused by NMS. First, we confirmed that NMS provoked impulsive behavior, orienting and nonselective attention-deficit, abnormal grooming, and depressive-like behaviors in adolescence. Excitatory amino acid carrier 1 (EAAC1) is an excitatory amino acid transporter expressed specifically by neurons and is the route for the neuronal uptake of glutamate/aspartate/cysteine. Compared with that in the normal control group, EAAC1 expression was remarkably reduced in the ventral hippocampus and cerebral cortex in the NMS group. Additionally, EAAC1 expression was reduced in parvalbumin-positive hippocampal GABAergic neurons in the NMS group. We also found that EAAC1-knockout (EAAC1−/−) mice exhibited impulsive-like, nonselective attention-deficit, and depressive-like behaviors compared with WT mice in adolescence, characteristics similar to those of the NMS behavior phenotype. Taken together, our results revealed that ELS induced a reduction in EAAC1 expression, suggesting that reduced EAAC1 expression is involved in the pathophysiology of attention-deficit and depressive behaviors in adolescence caused by NMS." @default.
- W3048215082 created "2020-08-13" @default.
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- W3048215082 date "2020-08-08" @default.
- W3048215082 modified "2023-10-16" @default.
- W3048215082 title "Early-life stress induces EAAC1 expression reduction and attention-deficit and depressive behaviors in adolescent rats" @default.
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- W3048215082 doi "https://doi.org/10.1038/s41420-020-00308-9" @default.
- W3048215082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7656241" @default.
- W3048215082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34365466" @default.
- W3048215082 hasPublicationYear "2020" @default.
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