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• W3048219186 endingPage "2582" @default.
• W3048219186 startingPage "2582" @default.
• W3048219186 abstract "The cell cycle, essential for biological functions, experiences delicate spatiotemporal regulation. The transition between G1 and S phase, which is called the proliferation–quiescence decision, is critical to the cell cycle. However, the stability and underlying stochastic dynamical mechanisms of the proliferation–quiescence decision have not been fully understood. To quantify the process of the proliferation–quiescence decision, we constructed its underlying landscape based on the relevant gene regulatory network. We identified three attractors on the landscape corresponding to the G0, G1, and S phases, individually, which are supported by single-cell data. By calculating the transition path, which quantifies the potential barrier, we built expression profiles in temporal order for key regulators in different transitions. We propose that the two saddle points on the landscape characterize restriction point (RP) and G1/S checkpoint, respectively, which provides quantitative and physical explanations for the mechanisms of Rb governing the RP while p21 controlling the G1/S checkpoint. We found that Emi1 inhibits the transition from G0 to G1, while Emi1 in a suitable range facilitates the transition from G1 to S. These results are partially consistent with previous studies, which also suggested new roles of Emi1 in the cell cycle. By global sensitivity analysis, we identified some critical regulatory factors influencing the proliferation–quiescence decision. Our work provides a global view of the stochasticity and dynamics in the proliferation–quiescence decision of the cell cycle." @default.
• W3048219186 created "2020-08-13" @default.
• W3048219186 creator A5071836973 @default.
• W3048219186 creator A5088679847 @default.
• W3048219186 date "2020-08-10" @default.
• W3048219186 modified "2023-09-26" @default.
• W3048219186 title "Quantifying the Landscape and Transition Paths for Proliferation–Quiescence Fate Decisions" @default.
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• W3048219186 cites W1527149712 @default.
• W3048219186 cites W1535321247 @default.
• W3048219186 cites W1970283086 @default.
• W3048219186 cites W1970779075 @default.
• W3048219186 cites W1984252723 @default.
• W3048219186 cites W1986759841 @default.
• W3048219186 cites W1989830594 @default.
• W3048219186 cites W1996533937 @default.
• W3048219186 cites W1999330214 @default.
• W3048219186 cites W2005692005 @default.
• W3048219186 cites W2011095025 @default.
• W3048219186 cites W2017540124 @default.
• W3048219186 cites W2025571730 @default.
• W3048219186 cites W2028984447 @default.
• W3048219186 cites W2029192858 @default.
• W3048219186 cites W2030461484 @default.
• W3048219186 cites W2035824523 @default.
• W3048219186 cites W2038696352 @default.
• W3048219186 cites W2040694119 @default.
• W3048219186 cites W2042811130 @default.
• W3048219186 cites W2046281923 @default.
• W3048219186 cites W2055164947 @default.
• W3048219186 cites W2057290799 @default.
• W3048219186 cites W2057869265 @default.
• W3048219186 cites W2058886425 @default.
• W3048219186 cites W2064670731 @default.
• W3048219186 cites W2070459069 @default.
• W3048219186 cites W2071949631 @default.
• W3048219186 cites W2075040103 @default.
• W3048219186 cites W2076650991 @default.
• W3048219186 cites W2077029264 @default.
• W3048219186 cites W2087719486 @default.
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• W3048219186 cites W2118668591 @default.
• W3048219186 cites W2118699566 @default.
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• W3048219186 cites W2136341530 @default.
• W3048219186 cites W2137961581 @default.
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• W3048219186 doi "https://doi.org/10.3390/jcm9082582" @default.
• W3048219186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7466041" @default.
• W3048219186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32784979" @default.
• W3048219186 hasPublicationYear "2020" @default.
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