FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048232459> ?p ?o ?g. }

• W3048232459 endingPage "1403" @default.
• W3048232459 startingPage "1395" @default.
• W3048232459 abstract "Abstract Background Head and neck squamous cell carcinomas (HNSCC) are malignant neoplasms with poor prognosis. Treatment-resistant cancer stem cell (CSC) is one reason for treatment failure. Considerable attention has been focused on sulforaphane (SF), a phytochemical from broccoli possessing anticancer properties. We investigated whether SF could enhance the chemotherapeutic effects of cisplatin (CIS) and 5-fluorouracil (5-FU) against HNSCC–CSCs, and its mechanisms of action. Methods CD44 + /CD271 + FACS-isolated CSCs from SCC12 and SCC38 human cell lines were treated with SF alone or combined with CIS or 5-FU. Cell viability, colony- and sphere-forming ability, apoptosis, CSC-related gene and protein expression and in vivo tumour growth were assessed. Safety of SF was tested on non-cancerous stem cells and in vivo. Results SF reduced HNSCC–CSC viability in a time- and dose-dependent manner. Combining SF increased the cytotoxicity of CIS twofold and 5-FU tenfold, with no effects on non-cancerous stem cell viability and functions. SF-combined treatments inhibited CSC colony and sphere formation, and tumour progression in vivo. Potential mechanisms of action included the stimulation of caspase-dependent apoptotic pathway, inhibition of SHH pathway and decreased expression of SOX2 and OCT4. Conclusions Combining SF allowed lower doses of CIS or 5-FU while enhancing these drug cytotoxicities against HNSCC–CSCs, with minimal effects on healthy cells." @default.
• W3048232459 created "2020-08-13" @default.
• W3048232459 creator A5072523216 @default.
• W3048232459 creator A5072979571 @default.
• W3048232459 date "2020-08-10" @default.
• W3048232459 modified "2023-10-06" @default.
• W3048232459 title "Broccoli extract increases drug-mediated cytotoxicity towards cancer stem cells of head and neck squamous cell carcinoma" @default.
• W3048232459 cites W1757407923 @default.
• W3048232459 cites W1975562877 @default.
• W3048232459 cites W1980684292 @default.
• W3048232459 cites W1999356404 @default.
• W3048232459 cites W2004434707 @default.
• W3048232459 cites W2008538532 @default.
• W3048232459 cites W2045732854 @default.
• W3048232459 cites W2047508350 @default.
• W3048232459 cites W2056878996 @default.
• W3048232459 cites W2061398650 @default.
• W3048232459 cites W2062069198 @default.
• W3048232459 cites W2071263262 @default.
• W3048232459 cites W2073059109 @default.
• W3048232459 cites W2076972080 @default.
• W3048232459 cites W2097269034 @default.
• W3048232459 cites W2116394959 @default.
• W3048232459 cites W2118287650 @default.
• W3048232459 cites W2122626910 @default.
• W3048232459 cites W2126129040 @default.
• W3048232459 cites W2128261003 @default.
• W3048232459 cites W2131059541 @default.
• W3048232459 cites W2134669826 @default.
• W3048232459 cites W2138498649 @default.
• W3048232459 cites W2140153695 @default.
• W3048232459 cites W2144020201 @default.
• W3048232459 cites W2145044290 @default.
• W3048232459 cites W2147631083 @default.
• W3048232459 cites W2149089218 @default.
• W3048232459 cites W2153101406 @default.
• W3048232459 cites W2154433934 @default.
• W3048232459 cites W2158799748 @default.
• W3048232459 cites W2160905744 @default.
• W3048232459 cites W2165769610 @default.
• W3048232459 cites W2166712471 @default.
• W3048232459 cites W2281254004 @default.
• W3048232459 cites W2566958631 @default.
• W3048232459 cites W2568391148 @default.
• W3048232459 cites W2590403118 @default.
• W3048232459 cites W2734271579 @default.
• W3048232459 cites W2792195018 @default.
• W3048232459 cites W2792864542 @default.
• W3048232459 cites W2887520055 @default.
• W3048232459 cites W2909429444 @default.
• W3048232459 cites W2953080824 @default.
• W3048232459 cites W2991295720 @default.
• W3048232459 cites W3125387772 @default.
• W3048232459 doi "https://doi.org/10.1038/s41416-020-1025-1" @default.
• W3048232459 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7591858" @default.
• W3048232459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32773768" @default.
• W3048232459 hasPublicationYear "2020" @default.
• W3048232459 type Work @default.
• W3048232459 sameAs 3048232459 @default.
• W3048232459 citedByCount "14" @default.
• W3048232459 countsByYear W30482324592021 @default.
• W3048232459 countsByYear W30482324592022 @default.
• W3048232459 countsByYear W30482324592023 @default.
• W3048232459 crossrefType "journal-article" @default.
• W3048232459 hasAuthorship W3048232459A5072523216 @default.
• W3048232459 hasAuthorship W3048232459A5072979571 @default.
• W3048232459 hasBestOaLocation W30482324591 @default.
• W3048232459 hasConcept C104317684 @default.
• W3048232459 hasConcept C109316439 @default.
• W3048232459 hasConcept C121608353 @default.
• W3048232459 hasConcept C126322002 @default.
• W3048232459 hasConcept C145103041 @default.
• W3048232459 hasConcept C1491633281 @default.
• W3048232459 hasConcept C150903083 @default.
• W3048232459 hasConcept C202751555 @default.
• W3048232459 hasConcept C207001950 @default.
• W3048232459 hasConcept C2776530083 @default.
• W3048232459 hasConcept C2776694085 @default.
• W3048232459 hasConcept C2776833033 @default.
• W3048232459 hasConcept C2777933648 @default.
• W3048232459 hasConcept C2778239845 @default.
• W3048232459 hasConcept C2780841255 @default.
• W3048232459 hasConcept C2780932548 @default.
• W3048232459 hasConcept C28328180 @default.
• W3048232459 hasConcept C502942594 @default.
• W3048232459 hasConcept C53227056 @default.
• W3048232459 hasConcept C55427017 @default.
• W3048232459 hasConcept C55493867 @default.
• W3048232459 hasConcept C71924100 @default.
• W3048232459 hasConcept C86803240 @default.
• W3048232459 hasConcept C95444343 @default.
• W3048232459 hasConcept C96232424 @default.
• W3048232459 hasConceptScore W3048232459C104317684 @default.
• W3048232459 hasConceptScore W3048232459C109316439 @default.
• W3048232459 hasConceptScore W3048232459C121608353 @default.
• W3048232459 hasConceptScore W3048232459C126322002 @default.
• W3048232459 hasConceptScore W3048232459C145103041 @default.
• W3048232459 hasConceptScore W3048232459C1491633281 @default.

• next