Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048247311> ?p ?o ?g. }
- W3048247311 abstract "Abstract Multivesicular bodies (MVBs) are endosome organelles that are gradually attracting research attention. Initially, MVBs were considered as important components of the endosomal-lysosomal degradation pathway. In recent years, with an increase in extracellular vesicle (EV) research, the biogenesis, fate, and pathological effects of MVBs have been increasingly studied. However, the mechanisms by which MVBs are sorted to the lysosome and plasma membrane remain unclear. In addition, whether the trafficking of MVBs can determine whether exosomes are released from cells, the factors are involved in cargo loading and regulating the fate of MVBs, and the roles that MVBs play in the development of disease are unknown. Consequently, this review focuses on the mechanism of MVB biogenesis, intraluminal vesicle formation, sorting of different cargoes, and regulation of their fate. We also discuss the mechanisms of emerging amphisome-dependent secretion and degradation. In addition, we highlight the contributions of MVBs to the heterogeneity of EVs, and their important roles in cancer. Thus, we attempt to unravel the various functions of MVBs in the cell and their multiple roles in tumor progression." @default.
- W3048247311 created "2020-08-13" @default.
- W3048247311 creator A5015475347 @default.
- W3048247311 creator A5026507924 @default.
- W3048247311 creator A5030986536 @default.
- W3048247311 creator A5061313869 @default.
- W3048247311 creator A5072818182 @default.
- W3048247311 date "2020-08-08" @default.
- W3048247311 modified "2023-10-18" @default.
- W3048247311 title "Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies" @default.
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