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• W3048247397 endingPage "9402" @default.
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• W3048247397 abstract "Available treatments for invasive fungal infections have limitations, including toxicity and the emergence of resistant strains. Therefore, there is an urgent need for alternative solutions. Because of their unique mode of action and high selectivity, plant defensins (PDs) are worthy therapeutic candidates. Chemical synthesis remains a preferred method for the production of many peptide-based therapeutics. Given the relatively long sequence of PDs, as well as their complicated posttranslational modifications, the synthetic route can be considered challenging. Here, we describe a total synthesis of PvD1, the defensin from the common bean Phaseolus vulgaris. Analytical, structural, and functional characterization revealed that both natural and synthetic peptides fold into a canonical CSαβ motif stabilized by conserved disulfide bonds. Moreover, synthetic PvD1 retained the biological activity against four different Candida species and showed no toxicity in vivo. Adding the high resistance of synthetic PvD1 to proteolytic degradation, we claim that conditions are now met to consider PDs druggable biologicals." @default.
• W3048247397 created "2020-08-13" @default.
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• W3048247397 date "2020-08-06" @default.
• W3048247397 modified "2023-10-15" @default.
• W3048247397 title "Synthesis, Structure, and Activity of the Antifungal Plant Defensin <i>Pv</i>D₁" @default.
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• W3048247397 doi "https://doi.org/10.1021/acs.jmedchem.0c00543" @default.
• W3048247397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32787086" @default.
• W3048247397 hasPublicationYear "2020" @default.
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