Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048247788> ?p ?o ?g. }
- W3048247788 endingPage "170" @default.
- W3048247788 startingPage "125" @default.
- W3048247788 abstract "During viral replication, herpesviruses utilize a unique strategy, termed nuclear egress, to translocate capsids from the nucleus into the cytoplasm. This initial budding step transfers a newly formed capsid from within the nucleus, too large to fit through nuclear pores, through the inner nuclear membrane to the perinuclear space. The perinuclear enveloped virion must then fuse with the outer nuclear membrane to be released into the cytoplasm for further maturation, undergoing budding once again at the trans-Golgi network or early endosomes, and ultimately exit the cell non-lytically to spread infection. This first budding process is mediated by two conserved viral proteins, UL31 and UL34, that form a heterodimer called the nuclear egress complex (NEC). This review focuses on what we know about how the NEC mediates capsid transport to the perinuclear space, including steps prior to and after this budding event. Additionally, we discuss the involvement of other viral proteins in this process and how NEC-mediated budding may be regulated during infection." @default.
- W3048247788 created "2020-08-13" @default.
- W3048247788 creator A5013793955 @default.
- W3048247788 creator A5047178569 @default.
- W3048247788 creator A5065636890 @default.
- W3048247788 date "2021-01-01" @default.
- W3048247788 modified "2023-10-10" @default.
- W3048247788 title "Nuclear Egress of Herpesviruses" @default.
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