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- W3048249333 abstract "Regional lymph node in- volvement, especially in axilla, re- mains the most important prognos- tic factor in breast cancer, both for locoregional relapse (LRR) and sur- vival. Locoregional radiotherapy (RT) reduces LRR rates by 50-70% and increases survival by 7-9%, as confirmed by EBCTCG. meta- analysis. The main LRR risk factors are: tumor site, number of axillary involvednodes,high grade,age un- der 40, and some molecular profi- les, such as triple negative and Her-2 overexpressed tumors. The global LRR prognosis is unfavo- rable, with approximately 50% of metastatic evolution at 5 years. The supraclavicular relapse risk, both after mastectomy and breast- conserving surgery, is reduced to under2%withRT.Internalmamma- ry nodes (IMN) are involved in 3- 16% and 10-43% among pN0 and pN+ tumors, respectively. The spe- cific RT impact on IMN is difficult to assess but recent studies seem to confirmtheimportanceofthistreat- ment in case of high LRR risk. Glo- bally, the axillary node involvement occurs in 30-35% of recent breast cancer series including a large pro- portion of screened tumors. The development of sentinel node biop- sy (SNB) allows a very important reduction of axillary dissection (AD) sequelae. If SNB is negative, local control is equivalent to AD. When SNB is positive (micrometa- stases or even macrometastases), some studies question the useful- ness of systematic complementary AD. In these cases, axillary RT seems a possible option, with seve- ral techniques." @default.
- W3048249333 created "2020-08-13" @default.
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- W3048249333 date "2013-01-01" @default.
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- W3048249333 title "Place de la radiothérapie dans le traitement des aires ganglionnaires du cancer du sein Role of radiotherapy in the treatment of lymph node sites in breast cancer" @default.
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