FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048251847> ?p ?o ?g. }

• W3048251847 endingPage "100454" @default.
• W3048251847 startingPage "100454" @default.
• W3048251847 abstract "The coronavirus disease 2019 (COVID-19) pandemic has spread rapidly worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for COVID-19, enters host cells via angiotensin-converting enzyme 2 (ACE2) and depletes ACE2, which is necessary for bradykinin metabolism. The depletion of ACE2 results in the accumulation of des-Arg (9)-bradykinin and possible bradykinin, both of which bind to bradykinin receptors and induce vasodilation, lung injury, and inflammation. It is well known that an overactivated contact system and excessive production of bradykinin comprise the key mechanisms that drive the pathogenesis of hereditary angioedema (HAE). It is reasonable to speculate that COVID-19 may increase disease activity in patients with HAE and vice versa. In this review, we explore the potential interactions between COVID-19 and HAE in terms of the contact system, the complement system, cytokine release, increased T helper 17 cells, and hematologic abnormalities. We conclude with the hypothesis that comorbidity with HAE might favor COVID-19 progression and may worsen its outcomes, while COVID-19 might in turn aggravate pre-existing HAE and prompt the onset of HAE in asymptomatic carriers of HAE-related mutations. Based on the pathophysiologic links, we suggest that long-term prophylaxis should be considered in patients with HAE at risk of SARS-CoV-2 infection, especially the prophylactic use of C1 inhibitor and lanadelumab and that HAE patients must have medications for acute attacks of angioedema. Additionally, therapeutic strategies employed in HAE should be considered for the treatment of COVID-19, and clinical trials should be performed." @default.
• W3048251847 created "2020-08-13" @default.
• W3048251847 creator A5053288966 @default.
• W3048251847 creator A5070602766 @default.
• W3048251847 creator A5073315295 @default.
• W3048251847 creator A5078900483 @default.
• W3048251847 date "2020-09-01" @default.
• W3048251847 modified "2023-10-11" @default.
• W3048251847 title "Does hereditary angioedema make COVID-19 worse?" @default.
• W3048251847 cites W1557125148 @default.
• W3048251847 cites W1919376524 @default.
• W3048251847 cites W1957579993 @default.
• W3048251847 cites W1967632907 @default.
• W3048251847 cites W1969791558 @default.
• W3048251847 cites W1969866147 @default.
• W3048251847 cites W1976684407 @default.
• W3048251847 cites W1990985479 @default.
• W3048251847 cites W2006249161 @default.
• W3048251847 cites W2010485658 @default.
• W3048251847 cites W2017572152 @default.
• W3048251847 cites W2022917731 @default.
• W3048251847 cites W2024447051 @default.
• W3048251847 cites W2024951985 @default.
• W3048251847 cites W2025267980 @default.
• W3048251847 cites W2039618925 @default.
• W3048251847 cites W2051827271 @default.
• W3048251847 cites W2051962479 @default.
• W3048251847 cites W2055068336 @default.
• W3048251847 cites W2058826224 @default.
• W3048251847 cites W2085977010 @default.
• W3048251847 cites W2091671824 @default.
• W3048251847 cites W2092462079 @default.
• W3048251847 cites W2093897672 @default.
• W3048251847 cites W2112164142 @default.
• W3048251847 cites W2113561458 @default.
• W3048251847 cites W2115565372 @default.
• W3048251847 cites W2117343102 @default.
• W3048251847 cites W2120345252 @default.
• W3048251847 cites W2136550873 @default.
• W3048251847 cites W2139008734 @default.
• W3048251847 cites W2166848757 @default.
• W3048251847 cites W2172262646 @default.
• W3048251847 cites W2257844160 @default.
• W3048251847 cites W2336770077 @default.
• W3048251847 cites W2399213186 @default.
• W3048251847 cites W2405529609 @default.
• W3048251847 cites W2429637832 @default.
• W3048251847 cites W2546495746 @default.
• W3048251847 cites W2623331963 @default.
• W3048251847 cites W2756541052 @default.
• W3048251847 cites W2796006889 @default.
• W3048251847 cites W2799963223 @default.
• W3048251847 cites W2806521568 @default.
• W3048251847 cites W2898080189 @default.
• W3048251847 cites W2942549919 @default.
• W3048251847 cites W2946022223 @default.
• W3048251847 cites W2968662460 @default.
• W3048251847 cites W3001118548 @default.
• W3048251847 cites W3001638293 @default.
• W3048251847 cites W3002108456 @default.
• W3048251847 cites W3007940623 @default.
• W3048251847 cites W3008461878 @default.
• W3048251847 cites W3009885589 @default.
• W3048251847 cites W3009912996 @default.
• W3048251847 cites W3010441732 @default.
• W3048251847 cites W3014050022 @default.
• W3048251847 cites W3014294089 @default.
• W3048251847 cites W3014573995 @default.
• W3048251847 cites W3016123694 @default.
• W3048251847 cites W3016461801 @default.
• W3048251847 cites W3017355196 @default.
• W3048251847 cites W3019130299 @default.
• W3048251847 cites W3020168167 @default.
• W3048251847 cites W3020423761 @default.
• W3048251847 cites W3020991691 @default.
• W3048251847 cites W3022120179 @default.
• W3048251847 cites W3023316367 @default.
• W3048251847 cites W3035577122 @default.
• W3048251847 cites W4246423891 @default.
• W3048251847 doi "https://doi.org/10.1016/j.waojou.2020.100454" @default.
• W3048251847 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7416729" @default.
• W3048251847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32834893" @default.
• W3048251847 hasPublicationYear "2020" @default.
• W3048251847 type Work @default.
• W3048251847 sameAs 3048251847 @default.
• W3048251847 citedByCount "17" @default.
• W3048251847 countsByYear W30482518472021 @default.
• W3048251847 countsByYear W30482518472022 @default.
• W3048251847 countsByYear W30482518472023 @default.
• W3048251847 crossrefType "journal-article" @default.
• W3048251847 hasAuthorship W3048251847A5053288966 @default.
• W3048251847 hasAuthorship W3048251847A5070602766 @default.
• W3048251847 hasAuthorship W3048251847A5073315295 @default.
• W3048251847 hasAuthorship W3048251847A5078900483 @default.
• W3048251847 hasBestOaLocation W30482518471 @default.
• W3048251847 hasConcept C126322002 @default.
• W3048251847 hasConcept C170493617 @default.
• W3048251847 hasConcept C203014093 @default.

• next