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- W3048258652 abstract "Abstract GABA A /glycine-mediated neuronal inhibition critically depends on intracellular chloride (Cl − ) concentration which is mainly regulated by the K + -Cl − co-transporter 2 (KCC2) in the adult central nervous system (CNS). KCC2 heterogeneity thus affects information processing across CNS areas. Here, we uncover a gradient in Cl − extrusion capacity across the superficial dorsal horn (SDH) of the spinal cord (laminae I-II: LI-LII), which remains concealed under low Cl − load. Under high Cl − load or heightened synaptic drive, lower Cl − extrusion is unveiled in LI, as expected from the gradient in KCC2 expression found across the SDH. Blocking TrkB receptors increases KCC2 in LI, pointing to differential constitutive TrkB activation across laminae. Higher Cl − lability in LI results in rapidly collapsing inhibition, and a form of activity-dependent synaptic plasticity expressed as a continuous facilitation of excitatory responses. The higher metaplasticity in LI as compared to LII differentially affects sensitization to thermal and mechanical input. Thus, inconspicuous heterogeneity of Cl − extrusion across laminae critically shapes plasticity for selective nociceptive modalities." @default.
- W3048258652 created "2020-08-13" @default.
- W3048258652 creator A5004685940 @default.
- W3048258652 creator A5017328884 @default.
- W3048258652 creator A5022113383 @default.
- W3048258652 creator A5041257902 @default.
- W3048258652 creator A5048862503 @default.
- W3048258652 creator A5063753938 @default.
- W3048258652 creator A5068939295 @default.
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- W3048258652 creator A5070640688 @default.
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- W3048258652 creator A5075809342 @default.
- W3048258652 creator A5088243863 @default.
- W3048258652 creator A5091048180 @default.
- W3048258652 date "2020-08-07" @default.
- W3048258652 modified "2023-10-18" @default.
- W3048258652 title "Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization" @default.
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