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- W3048261623 abstract "Abstract Many cancers lack the expression of methylthioadenosine phosphorylase (MTAP). These cancers require adenylosuccinate synthetase (AdSS) for nucleic acid synthesis. By inhibiting adenylosuccinate synthetase, we potentially have a new therapeutic agent. Bisubstrate inhibitors were synthesized and evaluated against purified AdSS. The best activity was obtained with adenosine bearing a four‐carbon linker that connects the N ‐formyl‐ N ‐hydroxy moiety to the 6‐position of the purine nucleoside." @default.
- W3048261623 created "2020-08-13" @default.
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- W3048261623 date "2020-09-10" @default.
- W3048261623 modified "2023-09-26" @default.
- W3048261623 title "Design, Synthesis and Evaluation of AdSS Bisubstrate Inhibitors" @default.
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- W3048261623 doi "https://doi.org/10.1002/cmdc.202000498" @default.
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