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- W3048262073 abstract "Abstract In drug development carbohydrate-based compounds are still not well represented, which is mainly because of their poor absorption and in vivo stability and overall polar character, but also their poor affinity. Multivalency is a principle that can be used to enhance affinities. While chelation i.e. bridging between binding sites, is a well understood multivalency mechanism, the effects due to statistical rebinding are far less obvious. In this chapter cases from the literature where statistical rebinding play a role are discussed in order to enhance our understanding." @default.
- W3048262073 created "2020-08-13" @default.
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- W3048262073 date "2020-01-01" @default.
- W3048262073 modified "2023-09-25" @default.
- W3048262073 title "Carbohydrate-protein interactions: Enhancing multivalency effects through statistical rebinding" @default.
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- W3048262073 doi "https://doi.org/10.1016/b978-0-12-816675-8.00009-9" @default.
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