FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048262575> ?p ?o ?g. }

• W3048262575 endingPage "1" @default.
• W3048262575 startingPage "1" @default.
• W3048262575 abstract "Primary gastrointestinal diffuse large B‑cell lymphoma (PGI‑DLBCL) is a highly heterogeneous type of non‑Hodgkin lymphoma. A number of studies have demonstrated that microRNA‑130a (miR‑130a) serves a role in the tumorigenesis and prognosis of numerous human tumors. However, to the best of our knowledge, the prognostic significance of miR‑130a in PGI‑DLBCL remains unknown. The present study explored the association between miR‑130a and the clinical outcomes of PGI‑DLBCL. Relative miR‑130a expression was assessed by reverse transcription‑quantitative PCR. Immunohistochemistry was used to detect expression levels of BCL‑2, c‑MYC, neprilysin, B‑cell lymphoma 6 protein, PWWP domain‑containing DNA repair factor 3A and proliferation marker protein Ki‑67. A receiver operating characteristic curve was constructed to analyze the specificity and sensitivity of microRNA levels in the diagnosis of PGI‑DLBCL. Survival curves were constructed using the Kaplan‑Meier method. In the present study, miR‑130a expression was notably higher in patients with PGI‑DLBCL compared with in the controls (P<0.0001). miR‑130a overexpression was closely associated with a high International Prognostic Index score (3‑5) and drug resistance (P=0.017 and P=0.044, respectively). No significant difference in other clinical features was observed. Patients with increased expression levels of miR‑130a had lower overall survival [hazard ratio (HR), 2.998; 95% CI, 1.347‑6.673; P=0.007] and progression‑free survival (HR, 3.325; 95% CI, 1.488‑7.429; P=0.003) compared with patients who had lower expression levels of miR‑130a. Furthermore, multivariate Cox regression analysis suggested that miR‑130a was a negative prognostic parameter in PGI‑DLBCL. Therefore, upregulation of miR‑130a could become a potential prognostic marker for PGI‑DLBCL. Additionally, further study of these results may have important guiding significance for the prognosis of patients with PGI‑DLBCL in the clinical setting." @default.
• W3048262575 created "2020-08-13" @default.
• W3048262575 creator A5001135284 @default.
• W3048262575 creator A5006621752 @default.
• W3048262575 creator A5016123040 @default.
• W3048262575 creator A5017142254 @default.
• W3048262575 creator A5027059038 @default.
• W3048262575 creator A5037143426 @default.
• W3048262575 creator A5041332463 @default.
• W3048262575 creator A5042265901 @default.
• W3048262575 creator A5044172930 @default.
• W3048262575 creator A5048091307 @default.
• W3048262575 creator A5060962435 @default.
• W3048262575 creator A5062410897 @default.
• W3048262575 creator A5067681000 @default.
• W3048262575 creator A5071030446 @default.
• W3048262575 creator A5082176762 @default.
• W3048262575 creator A5084717290 @default.
• W3048262575 creator A5088366028 @default.
• W3048262575 date "2020-08-06" @default.
• W3048262575 modified "2023-10-05" @default.
• W3048262575 title "Overexpression of microRNA‑130a predicts adverse prognosis of primary gastrointestinal diffuse large B‑cell lymphoma" @default.
• W3048262575 cites W1482778630 @default.
• W3048262575 cites W1648301895 @default.
• W3048262575 cites W1938011709 @default.
• W3048262575 cites W1966898198 @default.
• W3048262575 cites W1975829668 @default.
• W3048262575 cites W1976063215 @default.
• W3048262575 cites W1977838165 @default.
• W3048262575 cites W1982954728 @default.
• W3048262575 cites W1985990901 @default.
• W3048262575 cites W1992115508 @default.
• W3048262575 cites W2006070956 @default.
• W3048262575 cites W2010505937 @default.
• W3048262575 cites W2010853079 @default.
• W3048262575 cites W2012942268 @default.
• W3048262575 cites W2014651001 @default.
• W3048262575 cites W2015183287 @default.
• W3048262575 cites W2019490105 @default.
• W3048262575 cites W2025449301 @default.
• W3048262575 cites W2029222804 @default.
• W3048262575 cites W2040066648 @default.
• W3048262575 cites W2041703425 @default.
• W3048262575 cites W2050941456 @default.
• W3048262575 cites W2056641238 @default.
• W3048262575 cites W2075329854 @default.
• W3048262575 cites W2077091701 @default.
• W3048262575 cites W2093914407 @default.
• W3048262575 cites W2107277218 @default.
• W3048262575 cites W2108928912 @default.
• W3048262575 cites W2112255868 @default.
• W3048262575 cites W2121184787 @default.
• W3048262575 cites W2133575920 @default.
• W3048262575 cites W2158267770 @default.
• W3048262575 cites W2158335669 @default.
• W3048262575 cites W2159862107 @default.
• W3048262575 cites W2167439822 @default.
• W3048262575 cites W2192080449 @default.
• W3048262575 cites W2193826424 @default.
• W3048262575 cites W2197673939 @default.
• W3048262575 cites W2301170762 @default.
• W3048262575 cites W2301874383 @default.
• W3048262575 cites W2303788219 @default.
• W3048262575 cites W2315415505 @default.
• W3048262575 cites W2320902085 @default.
• W3048262575 cites W2331933097 @default.
• W3048262575 cites W2418653813 @default.
• W3048262575 cites W2418866759 @default.
• W3048262575 cites W2521321542 @default.
• W3048262575 cites W2529890319 @default.
• W3048262575 cites W2605336071 @default.
• W3048262575 cites W2611614316 @default.
• W3048262575 cites W2742332907 @default.
• W3048262575 cites W2794321299 @default.
• W3048262575 cites W2804681222 @default.
• W3048262575 cites W2806906092 @default.
• W3048262575 cites W2894211853 @default.
• W3048262575 cites W2912049913 @default.
• W3048262575 cites W2981236906 @default.
• W3048262575 cites W2983136758 @default.
• W3048262575 cites W75864458 @default.
• W3048262575 doi "https://doi.org/10.3892/ol.2020.11954" @default.
• W3048262575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7439117" @default.
• W3048262575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32831912" @default.
• W3048262575 hasPublicationYear "2020" @default.
• W3048262575 type Work @default.
• W3048262575 sameAs 3048262575 @default.
• W3048262575 citedByCount "3" @default.
• W3048262575 countsByYear W30482625752022 @default.
• W3048262575 countsByYear W30482625752023 @default.
• W3048262575 crossrefType "journal-article" @default.
• W3048262575 hasAuthorship W3048262575A5001135284 @default.
• W3048262575 hasAuthorship W3048262575A5006621752 @default.
• W3048262575 hasAuthorship W3048262575A5016123040 @default.
• W3048262575 hasAuthorship W3048262575A5017142254 @default.
• W3048262575 hasAuthorship W3048262575A5027059038 @default.
• W3048262575 hasAuthorship W3048262575A5037143426 @default.
• W3048262575 hasAuthorship W3048262575A5041332463 @default.

• next