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• W3048263079 endingPage "731" @default.
• W3048263079 startingPage "731" @default.
• W3048263079 abstract "Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon formed by the incomplete combustion of organic matter. Environmental B[a]P contamination poses a serious health risk to many organisms because the pollutant may negatively affect many physiological systems. As such, chronic exposure to B[a]P is known to lead to locomotor dysfunction and neurodegeneration in several organisms. In this study, we used the zebrafish model to delineate the acute toxic effects of B[a]P on the developing nervous system. We found that embryonic exposure of B[a]P downregulates shh and isl1, causing morphological hypoplasia in the telencephalon, ventral thalamus, hypothalamus, epiphysis and posterior commissure. Moreover, hypoxia-inducible factors (hif1a and hif2a) are repressed upon embryonic exposure of B[a]P, leading to reduced expression of the Hif-target genes, epo and survivin, which are associated with neural differentiation and maintenance. During normal embryogenesis, low-level oxidative stress regulates neuronal development and function. However, our experiments revealed that embryonic oxidative stress is greatly increased in B[a]P-treated embryos. The expression of catalase was decreased and sod1 expression increased in B[a]P-treated embryos. These transcriptional changes were coincident with increased embryonic levels of H2O2 and malondialdehyde, with the levels in B[a]P-treated fish similar to those in embryos treated with 120-μM H2O2. Together, our data suggest that reduced Hif signaling and increased oxidative stress are involved in B[a]P-induced acute neurotoxicity during embryogenesis." @default.
• W3048263079 created "2020-08-13" @default.
• W3048263079 creator A5018653134 @default.
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• W3048263079 date "2020-08-11" @default.
• W3048263079 modified "2023-10-09" @default.
• W3048263079 title "Integrated Hypoxia Signaling and Oxidative Stress in Developmental Neurotoxicity of Benzo[a]Pyrene in Zebrafish Embryos" @default.
• W3048263079 cites W1504583940 @default.
• W3048263079 cites W1589390349 @default.
• W3048263079 cites W1749022239 @default.
• W3048263079 cites W1893157084 @default.
• W3048263079 cites W1952870715 @default.
• W3048263079 cites W1964725564 @default.
• W3048263079 cites W1965191096 @default.
• W3048263079 cites W1966652499 @default.
• W3048263079 cites W1967679929 @default.
• W3048263079 cites W1968913560 @default.
• W3048263079 cites W1971455173 @default.
• W3048263079 cites W1981913094 @default.
• W3048263079 cites W1983317608 @default.
• W3048263079 cites W1984185923 @default.
• W3048263079 cites W1989991277 @default.
• W3048263079 cites W1990971990 @default.
• W3048263079 cites W1997136553 @default.
• W3048263079 cites W1999575328 @default.
• W3048263079 cites W2010983232 @default.
• W3048263079 cites W2012159035 @default.
• W3048263079 cites W2016294543 @default.
• W3048263079 cites W2021656373 @default.
• W3048263079 cites W2026171313 @default.
• W3048263079 cites W2029255665 @default.
• W3048263079 cites W2029850092 @default.
• W3048263079 cites W2030932036 @default.
• W3048263079 cites W2034858668 @default.
• W3048263079 cites W2046597024 @default.
• W3048263079 cites W2047960220 @default.
• W3048263079 cites W2058052005 @default.
• W3048263079 cites W2059071302 @default.
• W3048263079 cites W2061333433 @default.
• W3048263079 cites W2068167055 @default.
• W3048263079 cites W2071827462 @default.
• W3048263079 cites W2075662255 @default.
• W3048263079 cites W2078066068 @default.
• W3048263079 cites W2078295682 @default.
• W3048263079 cites W2078461629 @default.
• W3048263079 cites W2078759989 @default.
• W3048263079 cites W2079310705 @default.
• W3048263079 cites W2087991670 @default.
• W3048263079 cites W2088499209 @default.
• W3048263079 cites W2088609472 @default.
• W3048263079 cites W2106855201 @default.
• W3048263079 cites W2114579035 @default.
• W3048263079 cites W2125349610 @default.
• W3048263079 cites W2134798397 @default.
• W3048263079 cites W2137245835 @default.
• W3048263079 cites W2142283610 @default.
• W3048263079 cites W2147653980 @default.
• W3048263079 cites W2149562625 @default.
• W3048263079 cites W2150303379 @default.
• W3048263079 cites W2151068043 @default.
• W3048263079 cites W2152084055 @default.
• W3048263079 cites W2156464405 @default.
• W3048263079 cites W2162500283 @default.
• W3048263079 cites W2164069187 @default.
• W3048263079 cites W2168323957 @default.
• W3048263079 cites W2175835252 @default.
• W3048263079 cites W2227986439 @default.
• W3048263079 cites W2335106971 @default.
• W3048263079 cites W2337648208 @default.
• W3048263079 cites W2419141771 @default.
• W3048263079 cites W2461171027 @default.
• W3048263079 cites W2563656879 @default.
• W3048263079 cites W2567997524 @default.
• W3048263079 cites W2580449060 @default.
• W3048263079 cites W2737357581 @default.
• W3048263079 cites W2762961422 @default.
• W3048263079 cites W2778730710 @default.
• W3048263079 cites W2782388040 @default.
• W3048263079 cites W2801270229 @default.
• W3048263079 cites W2890888456 @default.
• W3048263079 cites W2904389548 @default.
• W3048263079 cites W2913353125 @default.
• W3048263079 cites W2951166561 @default.
• W3048263079 cites W2961458196 @default.
• W3048263079 cites W3004443605 @default.
• W3048263079 cites W3009163926 @default.
• W3048263079 cites W4243303276 @default.
• W3048263079 cites W4302195158 @default.
• W3048263079 cites W55391883 @default.
• W3048263079 cites W9191758 @default.
• W3048263079 doi "https://doi.org/10.3390/antiox9080731" @default.
• W3048263079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7464806" @default.
• W3048263079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32796530" @default.
• W3048263079 hasPublicationYear "2020" @default.

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