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- W3048263756 endingPage "101672" @default.
- W3048263756 startingPage "101672" @default.
- W3048263756 abstract "Oxidative stress is an important pathogenic manifestation of Alzheimer's disease (AD) that contributes to synaptic dysfunction, which precedes Aβ accumulation and neurofibrillary tangle formation. However, the molecular machineries that govern the decline of antioxidative defence in AD remains to be elucidated, and effective candidate for AD treatment is limited. Here, we showed that the decreases in the inhibitor of apoptosis-stimulating protein of p53 (iASPP) was associated with the vulnerability to oxidative stress in the amyloid precursor protein (APP)/presenilin 1 (PS1) mouse brain. Treatment with an antioxidant, syringin, could ameliorate AD-related pathologic and behavioural impairments. Interestingly, syringin treatment resulted in an upregulation of iASPP and the increase in the interaction of iASPP with Kelchlike ECH-associating protein 1 (Keap1). Syringin reduced neuronal apoptosis independently of p53. We confirmed that syringin-induced enhancement of antioxidant defenses involved the stabilization of Nrf2 in overexpressing human Swedish mutant APP (APPswe) cells in vitro. Syringin-mediated Nrf2 nuclear translocation facilitated the activation of the Nrf2 downstream genes via iASPP/Nrf2 axis. Our results demonstrate that syringin-mediated increases of iASPP-Keap1 interaction restore cellular redox balance. Further study on the syringin-iASPP interactions may help in understanding the regulatory mechanism and designing novel potent modulators for AD treatment." @default.
- W3048263756 created "2020-08-13" @default.
- W3048263756 creator A5007949406 @default.
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- W3048263756 creator A5067223991 @default.
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- W3048263756 creator A5084781002 @default.
- W3048263756 date "2020-09-01" @default.
- W3048263756 modified "2023-10-10" @default.
- W3048263756 title "Increases of iASPP-Keap1 interaction mediated by syringin enhance synaptic plasticity and rescue cognitive impairments via stabilizing Nrf2 in Alzheimer's models" @default.
- W3048263756 cites W138899936 @default.
- W3048263756 cites W1583707695 @default.
- W3048263756 cites W1609155228 @default.
- W3048263756 cites W1847017938 @default.
- W3048263756 cites W1922973595 @default.
- W3048263756 cites W1954454186 @default.
- W3048263756 cites W1965398535 @default.
- W3048263756 cites W1971116512 @default.
- W3048263756 cites W1971573216 @default.
- W3048263756 cites W1972763019 @default.
- W3048263756 cites W1974200088 @default.
- W3048263756 cites W1986105814 @default.
- W3048263756 cites W1989215722 @default.
- W3048263756 cites W1990679998 @default.
- W3048263756 cites W1992033043 @default.
- W3048263756 cites W1993976394 @default.
- W3048263756 cites W2000438866 @default.
- W3048263756 cites W2005914919 @default.
- W3048263756 cites W2006325384 @default.
- W3048263756 cites W2015243552 @default.
- W3048263756 cites W2015392958 @default.
- W3048263756 cites W2017464762 @default.
- W3048263756 cites W2019172653 @default.
- W3048263756 cites W2022290580 @default.
- W3048263756 cites W2026119731 @default.
- W3048263756 cites W2031762170 @default.
- W3048263756 cites W2037085321 @default.
- W3048263756 cites W2038245336 @default.
- W3048263756 cites W2038383414 @default.
- W3048263756 cites W2040114786 @default.
- W3048263756 cites W2041022152 @default.
- W3048263756 cites W2041722139 @default.
- W3048263756 cites W2042400232 @default.
- W3048263756 cites W2048695741 @default.
- W3048263756 cites W2050733310 @default.
- W3048263756 cites W2055515126 @default.
- W3048263756 cites W2068484477 @default.
- W3048263756 cites W2073121333 @default.
- W3048263756 cites W2085269111 @default.
- W3048263756 cites W2099748940 @default.
- W3048263756 cites W2102519816 @default.
- W3048263756 cites W2105132188 @default.
- W3048263756 cites W2109463068 @default.
- W3048263756 cites W2115338196 @default.
- W3048263756 cites W2118508998 @default.
- W3048263756 cites W2118898883 @default.
- W3048263756 cites W2127482883 @default.
- W3048263756 cites W2130503316 @default.
- W3048263756 cites W2132948185 @default.
- W3048263756 cites W2133103790 @default.
- W3048263756 cites W2141487162 @default.
- W3048263756 cites W2143713867 @default.
- W3048263756 cites W2146558971 @default.
- W3048263756 cites W2148034536 @default.
- W3048263756 cites W2151807575 @default.
- W3048263756 cites W2152554775 @default.
- W3048263756 cites W2152733195 @default.
- W3048263756 cites W2153112084 @default.
- W3048263756 cites W2153763774 @default.
- W3048263756 cites W2155324869 @default.
- W3048263756 cites W2157698069 @default.
- W3048263756 cites W2166977775 @default.
- W3048263756 cites W2293679413 @default.
- W3048263756 cites W2317316103 @default.
- W3048263756 cites W2396499774 @default.
- W3048263756 cites W2490715434 @default.
- W3048263756 cites W2611879222 @default.
- W3048263756 cites W2734031337 @default.
- W3048263756 cites W2763201457 @default.
- W3048263756 cites W2789746501 @default.
- W3048263756 cites W2800425544 @default.
- W3048263756 cites W2806212823 @default.
- W3048263756 cites W2885144936 @default.
- W3048263756 cites W2948544179 @default.
- W3048263756 cites W2979830091 @default.
- W3048263756 cites W2998985346 @default.
- W3048263756 cites W3007419636 @default.
- W3048263756 cites W4234110455 @default.
- W3048263756 doi "https://doi.org/10.1016/j.redox.2020.101672" @default.
- W3048263756 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7452088" @default.
- W3048263756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32828017" @default.
- W3048263756 hasPublicationYear "2020" @default.
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