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- W3048265140 endingPage "2178" @default.
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- W3048265140 abstract "Light-activated (“caged”) oligonucleotides provide a strategy for modulating the activity of antisense oligos, siRNA, miRNA, aptamers, DNAzymes, and mRNA-capturing probes with high spatiotemporal resolution. However, the near-UV and visible wavelengths that promote these bond-breaking reactions poorly penetrate living tissue, which limits some biological applications. To address this issue, we describe the first example of a protease-activated oligonucleotide probe, capable of reporting on caspase-3 during cellular apoptosis. The 2′-F RNA-peptide substrate-peptide nucleic acid (PNA) hairpin structure was generated in 30% yield in a single bioconjugation step." @default.
- W3048265140 created "2020-08-13" @default.
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- W3048265140 date "2020-08-07" @default.
- W3048265140 modified "2023-10-12" @default.
- W3048265140 title "Caspase-Activated Oligonucleotide Probe" @default.
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- W3048265140 doi "https://doi.org/10.1021/acs.bioconjchem.0c00362" @default.
- W3048265140 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8319955" @default.
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