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- W3048273726 endingPage "929" @default.
- W3048273726 startingPage "919" @default.
- W3048273726 abstract "Transporters of the solute carrier 6 (SLC6) family mediate the reuptake of neurotransmitters such as dopamine, norepinephrine, serotonin, GABA, and glycine. SLC6 family members are 12 transmembrane helix-spanning proteins that operate using the transmembrane sodium gradient for transport. These transporters assume various quaternary arrangements ranging from monomers to complex stoichiometries with multiple subunits. Dopamine and serotonin transporter oligomerization has been implicated in trafficking of newly formed proteins from the endoplasmic reticulum to the plasma membrane with a pre-fixed assembly. Once at the plasma membrane, oligomers are kept fixed in their quaternary assembly by interaction with phosphoinositides. While it remains unclear how oligomer formation precisely affects physiological transporter function, it has been shown that oligomerization supports the activity of release-type psychostimulants. Most recently, single molecule microscopy experiments unveiled that the stoichiometry differs between individual members of the SLC6 family. The present overview summarizes our understanding of the influence of plasma membrane constituents on transporter oligomerization, describes the known interfaces between protomers and discusses open questions." @default.
- W3048273726 created "2020-08-13" @default.
- W3048273726 creator A5020951431 @default.
- W3048273726 creator A5034015135 @default.
- W3048273726 creator A5039290263 @default.
- W3048273726 creator A5043970989 @default.
- W3048273726 creator A5044984957 @default.
- W3048273726 creator A5051240927 @default.
- W3048273726 creator A5054041312 @default.
- W3048273726 creator A5079264101 @default.
- W3048273726 date "2020-08-28" @default.
- W3048273726 modified "2023-10-17" @default.
- W3048273726 title "SLC6 transporter oligomerization" @default.
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