FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048275025> ?p ?o ?g. }

• W3048275025 endingPage "374" @default.
• W3048275025 startingPage "364" @default.
• W3048275025 abstract "To design and synthesize folate-modified pH-responsive chitosan-based nanomicelles and investigate the in vitro anti-tumor activity of the drug-loaded micelles.CHI-DMA was obtained by reductive amination reaction of aldehyde-based chitosan and hydrophilic amine compounds, and CHI-DMA-LA was obtained by condensation reaction with lauric acid; FA-CHI-DMA-LA was obtained after modification with folic acid (FA). The drug-loaded nanomicelles FA-CHI-DMA-LA/DOX were assembled by solvent change method. The physicochemical properties of polymers were characterized by hydrogen nuclear magnetic resonance and transmission electron microscope. The particle size and surface potential were determined by dynamic light scattering method. Folic acid access rate, doxorubicin (DOX) loading rate and entrapped efficiency were measured by UV-vis spectrophotometer. The drug release properties of DOX-loaded micelles in vitro were monitored by fluorescence spectrophotometer at different pHs (7.4, 6.5, 5.0). The cytotoxicity against human oral cancer KB cells was detected by MTT assay. Fluorescence microscope and flow cytometry were applied to investigate the phagocytosis of DOX-loaded micelles on KB cells.FA-CHI-DMA-LA was synthesized. The particle sizes of FA-CHI-DMA-LA-1 and FA-CHI-DMA-LA-2 micelles which used for the subsequent experiments were (73±14) nm and (106±15) nm, zeta potential were (15.59±1.98) mV and (21.20±2.35) mV, respectively. The drug loading rates of drug-loaded micelles FA-CHI-DMA-LA-1/DOX and FA-CHI-DMA-LA-2/DOX are (4.08±1.12)%and (4.12±0.44)%, respectively. In vitro drug release is pH-responsive, with cumulative release of DOX up to 37%and 36%at pH 5.0, which is about 1.5 times higher than that of pH 7.4. For FA-CHI-DMA-LA micelles with 1.25 to 125 μg/mL concentration, the survival rate of KB cells is more than 70%after incubation for 24 hours. The cell uptake of FA-CHI-DMA-LA/DOX micelles was enhanced compared to CHI-DMA-LA/DOX, and the cell uptake was higher in incubation without FA medium than that with FA. Compared with free DOX or CHI-DMA-LA/DOX, FA-CHI-DMA-LA/DOX nanomicelles showed higher cyctoxicity to KB cells, especially the FA-CHI-DMA-LA-2/DOX nanomicelles, the cell survival rate was about 17% after incubation for 24 hours.FA-modified chitosan-based nanomicelle with good biocompatibility was successfully prepared, which exhibits tumor microenvironmental pH responsive drug release and tumor targeting." @default.
• W3048275025 created "2020-08-13" @default.
• W3048275025 creator A5013363643 @default.
• W3048275025 creator A5046225712 @default.
• W3048275025 creator A5058181897 @default.
• W3048275025 creator A5065668567 @default.
• W3048275025 creator A5068668644 @default.
• W3048275025 creator A5077542931 @default.
• W3048275025 date "2020-05-25" @default.
• W3048275025 modified "2023-10-01" @default.
• W3048275025 title "[Synthesis of folate modified chitosan-based nanomicelles and its in vitro anti-tumor activity]." @default.
• W3048275025 cites W1982985645 @default.
• W3048275025 cites W1997787046 @default.
• W3048275025 cites W2013523297 @default.
• W3048275025 cites W2016156919 @default.
• W3048275025 cites W2042493999 @default.
• W3048275025 cites W2046528901 @default.
• W3048275025 cites W2067848116 @default.
• W3048275025 cites W2088223764 @default.
• W3048275025 cites W2089645494 @default.
• W3048275025 cites W2105678378 @default.
• W3048275025 cites W2166984808 @default.
• W3048275025 cites W2189336870 @default.
• W3048275025 cites W2210667319 @default.
• W3048275025 cites W2256521570 @default.
• W3048275025 cites W2567395185 @default.
• W3048275025 cites W2762985877 @default.
• W3048275025 cites W2803010851 @default.
• W3048275025 cites W2806683929 @default.
• W3048275025 cites W2898106647 @default.
• W3048275025 cites W2923345629 @default.
• W3048275025 cites W2959067117 @default.
• W3048275025 doi "https://doi.org/10.3785/j.issn.1008-9292.2020.06.03" @default.
• W3048275025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32762172" @default.
• W3048275025 hasPublicationYear "2020" @default.
• W3048275025 type Work @default.
• W3048275025 sameAs 3048275025 @default.
• W3048275025 citedByCount "0" @default.
• W3048275025 crossrefType "journal-article" @default.
• W3048275025 hasAuthorship W3048275025A5013363643 @default.
• W3048275025 hasAuthorship W3048275025A5046225712 @default.
• W3048275025 hasAuthorship W3048275025A5058181897 @default.
• W3048275025 hasAuthorship W3048275025A5065668567 @default.
• W3048275025 hasAuthorship W3048275025A5068668644 @default.
• W3048275025 hasAuthorship W3048275025A5077542931 @default.
• W3048275025 hasConcept C11268172 @default.
• W3048275025 hasConcept C13965031 @default.
• W3048275025 hasConcept C14631669 @default.
• W3048275025 hasConcept C155672457 @default.
• W3048275025 hasConcept C171250308 @default.
• W3048275025 hasConcept C178790620 @default.
• W3048275025 hasConcept C184651966 @default.
• W3048275025 hasConcept C185592680 @default.
• W3048275025 hasConcept C192562407 @default.
• W3048275025 hasConcept C2779732960 @default.
• W3048275025 hasConcept C86181022 @default.
• W3048275025 hasConceptScore W3048275025C11268172 @default.
• W3048275025 hasConceptScore W3048275025C13965031 @default.
• W3048275025 hasConceptScore W3048275025C14631669 @default.
• W3048275025 hasConceptScore W3048275025C155672457 @default.
• W3048275025 hasConceptScore W3048275025C171250308 @default.
• W3048275025 hasConceptScore W3048275025C178790620 @default.
• W3048275025 hasConceptScore W3048275025C184651966 @default.
• W3048275025 hasConceptScore W3048275025C185592680 @default.
• W3048275025 hasConceptScore W3048275025C192562407 @default.
• W3048275025 hasConceptScore W3048275025C2779732960 @default.
• W3048275025 hasConceptScore W3048275025C86181022 @default.
• W3048275025 hasIssue "3" @default.
• W3048275025 hasLocation W30482750251 @default.
• W3048275025 hasOpenAccess W3048275025 @default.
• W3048275025 hasPrimaryLocation W30482750251 @default.
• W3048275025 hasRelatedWork W10664810 @default.
• W3048275025 hasRelatedWork W10821580 @default.
• W3048275025 hasRelatedWork W11117660 @default.
• W3048275025 hasRelatedWork W16767519 @default.
• W3048275025 hasRelatedWork W18535981 @default.
• W3048275025 hasRelatedWork W20750182 @default.
• W3048275025 hasRelatedWork W2977318 @default.
• W3048275025 hasRelatedWork W4520280 @default.
• W3048275025 hasRelatedWork W5926037 @default.
• W3048275025 hasRelatedWork W9171967 @default.
• W3048275025 hasVolume "49" @default.
• W3048275025 isParatext "false" @default.
• W3048275025 isRetracted "false" @default.
• W3048275025 magId "3048275025" @default.
• W3048275025 workType "article" @default.