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- W3048285610 endingPage "1162" @default.
- W3048285610 startingPage "1162" @default.
- W3048285610 abstract "As a nodal mediator of pyruvate metabolism, the mitochondrial pyruvate carrier (MPC) plays a pivotal role in many physiological and pathological processes across the human lifespan, from embryonic development to aging-associated neurodegeneration. Emerging research highlights the importance of the MPC in diverse conditions, such as immune cell activation, cancer cell stemness, and dopamine production in Parkinson’s disease models. Whether MPC function ameliorates or contributes to disease is highly specific to tissue and cell type. Cell- and tissue-specific differences in MPC content and activity suggest that MPC function is tightly regulated as a mechanism of metabolic, cellular, and organismal control. Accordingly, recent studies on cancer and diabetes have identified protein–protein interactions, post-translational processes, and transcriptional factors that modulate MPC function. This growing body of literature demonstrates that the MPC and other mitochondrial carriers comprise a versatile and dynamic network undergirding the metabolism of health and disease." @default.
- W3048285610 created "2020-08-13" @default.
- W3048285610 creator A5039884788 @default.
- W3048285610 creator A5058481769 @default.
- W3048285610 date "2020-08-08" @default.
- W3048285610 modified "2023-09-27" @default.
- W3048285610 title "Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan" @default.
- W3048285610 cites W1503675015 @default.
- W3048285610 cites W15282186 @default.
- W3048285610 cites W1762789982 @default.
- W3048285610 cites W1819285150 @default.
- W3048285610 cites W1845254999 @default.
- W3048285610 cites W1900054156 @default.
- W3048285610 cites W1932854961 @default.
- W3048285610 cites W1968996277 @default.
- W3048285610 cites W1976613901 @default.
- W3048285610 cites W1981961082 @default.
- W3048285610 cites W1983107759 @default.
- W3048285610 cites W1985236262 @default.
- W3048285610 cites W1990573718 @default.
- W3048285610 cites W1991290396 @default.
- W3048285610 cites W2013334588 @default.
- W3048285610 cites W2016304131 @default.
- W3048285610 cites W2019750161 @default.
- W3048285610 cites W2021597697 @default.
- W3048285610 cites W2024021877 @default.
- W3048285610 cites W2045887831 @default.
- W3048285610 cites W2051857619 @default.
- W3048285610 cites W2058005998 @default.
- W3048285610 cites W2058387746 @default.
- W3048285610 cites W2088744527 @default.
- W3048285610 cites W2091396330 @default.
- W3048285610 cites W2094229041 @default.
- W3048285610 cites W2095903025 @default.
- W3048285610 cites W2097259163 @default.
- W3048285610 cites W2108668627 @default.
- W3048285610 cites W2114805483 @default.
- W3048285610 cites W2128666074 @default.
- W3048285610 cites W2135447662 @default.
- W3048285610 cites W2137418169 @default.
- W3048285610 cites W2151980465 @default.
- W3048285610 cites W2164178708 @default.
- W3048285610 cites W2168941586 @default.
- W3048285610 cites W2217440254 @default.
- W3048285610 cites W2258066491 @default.
- W3048285610 cites W2279261475 @default.
- W3048285610 cites W2281668243 @default.
- W3048285610 cites W2286971754 @default.
- W3048285610 cites W2301353106 @default.
- W3048285610 cites W2381125605 @default.
- W3048285610 cites W2396811662 @default.
- W3048285610 cites W2467705229 @default.
- W3048285610 cites W2473268164 @default.
- W3048285610 cites W2519338564 @default.
- W3048285610 cites W2519544249 @default.
- W3048285610 cites W2550214706 @default.
- W3048285610 cites W2553707323 @default.
- W3048285610 cites W2558950003 @default.
- W3048285610 cites W2559001989 @default.
- W3048285610 cites W2560669064 @default.
- W3048285610 cites W2563249905 @default.
- W3048285610 cites W2585217465 @default.
- W3048285610 cites W2591756301 @default.
- W3048285610 cites W2605646337 @default.
- W3048285610 cites W2614553141 @default.
- W3048285610 cites W2617805631 @default.
- W3048285610 cites W2624427760 @default.
- W3048285610 cites W2746891430 @default.
- W3048285610 cites W2749736089 @default.
- W3048285610 cites W2760183031 @default.
- W3048285610 cites W2765303057 @default.
- W3048285610 cites W2770696006 @default.
- W3048285610 cites W2775714114 @default.
- W3048285610 cites W2784020799 @default.
- W3048285610 cites W2790858728 @default.
- W3048285610 cites W2792934495 @default.
- W3048285610 cites W2797783284 @default.
- W3048285610 cites W2799366000 @default.
- W3048285610 cites W2801228399 @default.
- W3048285610 cites W2802713607 @default.
- W3048285610 cites W2802966297 @default.
- W3048285610 cites W2886969890 @default.
- W3048285610 cites W2887805484 @default.
- W3048285610 cites W2895536438 @default.
- W3048285610 cites W2898906105 @default.
- W3048285610 cites W2900888169 @default.
- W3048285610 cites W2911486911 @default.
- W3048285610 cites W2912309272 @default.
- W3048285610 cites W2913677780 @default.
- W3048285610 cites W2916531351 @default.
- W3048285610 cites W2941260093 @default.
- W3048285610 cites W2947039292 @default.
- W3048285610 cites W2948482344 @default.
- W3048285610 cites W2950406723 @default.
- W3048285610 cites W2950637776 @default.
- W3048285610 cites W2957411242 @default.
- W3048285610 cites W2971634364 @default.
- W3048285610 cites W2972083076 @default.