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- W3048288662 abstract "Prostate cancer (PCa) accounts for a high number of deaths in males with no available curative treatments. Patients with PCa are commonly diagnosed in advanced stages due to the lack of symptoms in the early stages. Recently, the research focus was directed toward gene editing in cancer therapy. Small interfering RNA (siRNA) intervention is considered as a powerful tool for gene silencing (knockdown), enabling the suppression of oncogene factors in cancer. This strategy is applied to the treatment of various cancers including PCa. The siRNA can inhibit proliferation and invasion of PCa cells and is able to promote the anti-tumor activity of chemotherapeutic agents. However, the off-target effects of siRNA therapy remarkably reduce its efficacy in PCa therapy. To date, various carriers were designed to improve the delivery of siRNA and, among them, nanoparticles are of importance. Nanoparticles enable the targeted delivery of siRNAs and enhance their potential in the downregulation of target genes of interest. Additionally, nanoparticles can provide a platform for the co-delivery of siRNAs and anti-tumor drugs, resulting in decreased growth and migration of PCa cells. The efficacy, specificity, and delivery of siRNAs are comprehensively discussed in this review to direct further studies toward using siRNAs and their nanoscale-delivery systems in PCa therapy and perhaps other cancer types." @default.
- W3048288662 created "2020-08-13" @default.
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- W3048288662 date "2020-08-10" @default.
- W3048288662 modified "2023-10-07" @default.
- W3048288662 title "Progress in Delivery of siRNA-Based Therapeutics Employing Nano-Vehicles for Treatment of Prostate Cancer" @default.
- W3048288662 cites W1490477754 @default.
- W3048288662 cites W1519967758 @default.
- W3048288662 cites W1521698887 @default.
- W3048288662 cites W1527337061 @default.
- W3048288662 cites W1549342368 @default.
- W3048288662 cites W1595803348 @default.
- W3048288662 cites W1611419331 @default.
- W3048288662 cites W1845572554 @default.
- W3048288662 cites W1905015000 @default.
- W3048288662 cites W1907272683 @default.
- W3048288662 cites W1951507118 @default.
- W3048288662 cites W1963992284 @default.
- W3048288662 cites W1965376764 @default.
- W3048288662 cites W1967239931 @default.
- W3048288662 cites W1970615527 @default.
- W3048288662 cites W1974891955 @default.
- W3048288662 cites W1982920098 @default.
- W3048288662 cites W1983359649 @default.
- W3048288662 cites W1983434934 @default.
- W3048288662 cites W1991174952 @default.
- W3048288662 cites W1992282866 @default.
- W3048288662 cites W1994880314 @default.
- W3048288662 cites W1995866768 @default.
- W3048288662 cites W1996159020 @default.
- W3048288662 cites W1997730945 @default.
- W3048288662 cites W2001018320 @default.
- W3048288662 cites W2003123099 @default.
- W3048288662 cites W2008426300 @default.
- W3048288662 cites W2008971936 @default.
- W3048288662 cites W2011071742 @default.
- W3048288662 cites W2012263583 @default.
- W3048288662 cites W2015453163 @default.
- W3048288662 cites W2016963553 @default.
- W3048288662 cites W2019589189 @default.
- W3048288662 cites W2020921736 @default.
- W3048288662 cites W2022903909 @default.
- W3048288662 cites W2023186109 @default.
- W3048288662 cites W2023805319 @default.
- W3048288662 cites W2025540821 @default.
- W3048288662 cites W2027598957 @default.
- W3048288662 cites W2029987876 @default.
- W3048288662 cites W2030845523 @default.
- W3048288662 cites W2031147341 @default.
- W3048288662 cites W2032347891 @default.
- W3048288662 cites W2033109960 @default.
- W3048288662 cites W2033384015 @default.
- W3048288662 cites W2034700471 @default.
- W3048288662 cites W2038660811 @default.
- W3048288662 cites W2039103775 @default.
- W3048288662 cites W2045840497 @default.
- W3048288662 cites W2048203525 @default.
- W3048288662 cites W2052025930 @default.
- W3048288662 cites W2055631278 @default.
- W3048288662 cites W2058531312 @default.
- W3048288662 cites W2060674723 @default.
- W3048288662 cites W2067587422 @default.
- W3048288662 cites W2072171560 @default.
- W3048288662 cites W2073662815 @default.
- W3048288662 cites W2073854653 @default.
- W3048288662 cites W2073947785 @default.
- W3048288662 cites W2075246605 @default.
- W3048288662 cites W2076485183 @default.
- W3048288662 cites W2080537375 @default.
- W3048288662 cites W2080794316 @default.
- W3048288662 cites W2080823739 @default.
- W3048288662 cites W2081438603 @default.
- W3048288662 cites W2084891840 @default.
- W3048288662 cites W2085165779 @default.
- W3048288662 cites W2088267349 @default.
- W3048288662 cites W2092284733 @default.
- W3048288662 cites W2100756069 @default.
- W3048288662 cites W2107151134 @default.
- W3048288662 cites W2108882170 @default.
- W3048288662 cites W2109001167 @default.
- W3048288662 cites W2116670113 @default.
- W3048288662 cites W2119621449 @default.
- W3048288662 cites W2124198483 @default.
- W3048288662 cites W2126851107 @default.