Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048298318> ?p ?o ?g. }
- W3048298318 endingPage "127792" @default.
- W3048298318 startingPage "127792" @default.
- W3048298318 abstract "Tebuconazole is a triazole fungicide, used in agriculture to treat phytopathogenic fungi, and as a biocide, has been reported to be related to reproductive and developmental toxicity. The purpose of this study was to investigate the effect of tebuconazole exposure on rat fetal Leydig cells and fetal testis during pregnancy. Pregnant Sprague-Dawley rats were randomly divided into 4 groups, daily gavaged with corn oil (as a control), 25, 50, and 100 mg/kg body weight tebuconazole for 10 days (from the 12th day of pregnancy). Tebuconazole increased fetal serum testosterone and progesterone levels at a dose of 100 mg/kg. Exposure to 100 mg/kg tebuconazole significantly caused an increase in the number of fetal Leydig cells per testis without inducing cell aggregation. Tebuconazole up-regulated the expression of Star, Cyp11a1, Hsd17b3, and Fshr and their proteins. Further investigation found that tebuconazole caused increased phosphorylation of AKT1, ERK1/2, and mTOR, the level of BCL2, as well as the decrease of Beclin1, LC3B, and BAX, which may contribute to the fetal Leydig cell autophagy and proliferation. In conclusion, in utero exposure of tebuconazole causes the proliferation of fetal Leydig cells." @default.
- W3048298318 created "2020-08-13" @default.
- W3048298318 creator A5000935555 @default.
- W3048298318 creator A5026485648 @default.
- W3048298318 creator A5027516492 @default.
- W3048298318 creator A5035293596 @default.
- W3048298318 creator A5040406694 @default.
- W3048298318 creator A5060810308 @default.
- W3048298318 creator A5062193442 @default.
- W3048298318 creator A5064842058 @default.
- W3048298318 creator A5076708754 @default.
- W3048298318 date "2021-01-01" @default.
- W3048298318 modified "2023-10-14" @default.
- W3048298318 title "Gestational exposure to tebuconazole affects the development of rat fetal Leydig cells" @default.
- W3048298318 cites W1780295430 @default.
- W3048298318 cites W1993600245 @default.
- W3048298318 cites W1993836723 @default.
- W3048298318 cites W1995279669 @default.
- W3048298318 cites W1997437509 @default.
- W3048298318 cites W2001675597 @default.
- W3048298318 cites W2010336249 @default.
- W3048298318 cites W2019699782 @default.
- W3048298318 cites W2019750190 @default.
- W3048298318 cites W2026654575 @default.
- W3048298318 cites W2027215921 @default.
- W3048298318 cites W2035036582 @default.
- W3048298318 cites W2038397637 @default.
- W3048298318 cites W2043226290 @default.
- W3048298318 cites W2055971882 @default.
- W3048298318 cites W2057274775 @default.
- W3048298318 cites W2065634561 @default.
- W3048298318 cites W2067692987 @default.
- W3048298318 cites W2081236313 @default.
- W3048298318 cites W2108059256 @default.
- W3048298318 cites W2140439371 @default.
- W3048298318 cites W2145375432 @default.
- W3048298318 cites W2152435679 @default.
- W3048298318 cites W2159993610 @default.
- W3048298318 cites W2165192354 @default.
- W3048298318 cites W2171581152 @default.
- W3048298318 cites W2300063055 @default.
- W3048298318 cites W2604178526 @default.
- W3048298318 cites W2732818952 @default.
- W3048298318 cites W2790271963 @default.
- W3048298318 cites W2795609741 @default.
- W3048298318 cites W2903825393 @default.
- W3048298318 cites W2907053279 @default.
- W3048298318 cites W2945533976 @default.
- W3048298318 doi "https://doi.org/10.1016/j.chemosphere.2020.127792" @default.
- W3048298318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32805656" @default.
- W3048298318 hasPublicationYear "2021" @default.
- W3048298318 type Work @default.
- W3048298318 sameAs 3048298318 @default.
- W3048298318 citedByCount "15" @default.
- W3048298318 countsByYear W30482983182021 @default.
- W3048298318 countsByYear W30482983182022 @default.
- W3048298318 countsByYear W30482983182023 @default.
- W3048298318 crossrefType "journal-article" @default.
- W3048298318 hasAuthorship W3048298318A5000935555 @default.
- W3048298318 hasAuthorship W3048298318A5026485648 @default.
- W3048298318 hasAuthorship W3048298318A5027516492 @default.
- W3048298318 hasAuthorship W3048298318A5035293596 @default.
- W3048298318 hasAuthorship W3048298318A5040406694 @default.
- W3048298318 hasAuthorship W3048298318A5060810308 @default.
- W3048298318 hasAuthorship W3048298318A5062193442 @default.
- W3048298318 hasAuthorship W3048298318A5064842058 @default.
- W3048298318 hasAuthorship W3048298318A5076708754 @default.
- W3048298318 hasConcept C126322002 @default.
- W3048298318 hasConcept C134018914 @default.
- W3048298318 hasConcept C16685009 @default.
- W3048298318 hasConcept C172680121 @default.
- W3048298318 hasConcept C185592680 @default.
- W3048298318 hasConcept C201614185 @default.
- W3048298318 hasConcept C2777736315 @default.
- W3048298318 hasConcept C2778575703 @default.
- W3048298318 hasConcept C2779234561 @default.
- W3048298318 hasConcept C2779279991 @default.
- W3048298318 hasConcept C2780125187 @default.
- W3048298318 hasConcept C54355233 @default.
- W3048298318 hasConcept C59822182 @default.
- W3048298318 hasConcept C71315377 @default.
- W3048298318 hasConcept C71924100 @default.
- W3048298318 hasConcept C74600772 @default.
- W3048298318 hasConcept C86803240 @default.
- W3048298318 hasConceptScore W3048298318C126322002 @default.
- W3048298318 hasConceptScore W3048298318C134018914 @default.
- W3048298318 hasConceptScore W3048298318C16685009 @default.
- W3048298318 hasConceptScore W3048298318C172680121 @default.
- W3048298318 hasConceptScore W3048298318C185592680 @default.
- W3048298318 hasConceptScore W3048298318C201614185 @default.
- W3048298318 hasConceptScore W3048298318C2777736315 @default.
- W3048298318 hasConceptScore W3048298318C2778575703 @default.
- W3048298318 hasConceptScore W3048298318C2779234561 @default.
- W3048298318 hasConceptScore W3048298318C2779279991 @default.
- W3048298318 hasConceptScore W3048298318C2780125187 @default.
- W3048298318 hasConceptScore W3048298318C54355233 @default.
- W3048298318 hasConceptScore W3048298318C59822182 @default.
- W3048298318 hasConceptScore W3048298318C71315377 @default.