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• W3048306711 abstract "In the present study, we investigated the role of mechanical load as generated by amniotic fluid in the vocal fold embryogenesis. In utero , amniotic fluid flows through the laryngeal inlet down into the lungs during fetal breathing and swallowing. In a mouse model, the onset of fetal breathing coincides with epithelial lamina recanalization. The epithelial lamina is a temporal structure that is formed during early stages of the larynx development and is gradually resorbed whereby joining the upper and lower airways. Here, we show that a temporary decrease in mechanical load secondary to drainage of amniotic fluid and subsequent flow restoration, impaired timing of epithelial lamina disintegration. Moreover, re-accumulation of fluid in the laryngeal region led to VF tissue deformation triggering remodeling of the epithelium and pressure generated changes in the elastic properties of the lamina propria, as measured by atomic force microscopy. We further show that load-related structural changes were likely mediated by Piezo 1 –Yap signaling pathway in the vocal fold epithelium. Understanding the relationship between the mechanical and biological parameters in the larynx is key to gaining insights into pathogenesis of congenital laryngeal disorders as well as mechanisms of vocal fold tissue remodeling in response to mechanotransduction. • Drainage of amniotic fluid delays vocal fold separation. • Decreased and consequent flow restoration induces remodeling of the epithelium. • Changes in mechanical load alter the stiffness of the lamina propria. • Load-related remodeling of the mucosa is likely regulated by Piezo 1-Yap signaling." @default.
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• W3048306711 date "2020-10-01" @default.
• W3048306711 modified "2023-09-26" @default.
• W3048306711 title "Drainage of amniotic fluid delays vocal fold separation and induces load-related vocal fold mucosa remodeling" @default.
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• W3048306711 doi "https://doi.org/10.1016/j.ydbio.2020.08.003" @default.
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