Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048308846> ?p ?o ?g. }
- W3048308846 endingPage "89" @default.
- W3048308846 startingPage "77" @default.
- W3048308846 abstract "Osteosarcoma remains an unmet medical need. Oncolytic viruses are gaining traction as novel cancer therapeutics. These viruses are either naturally nonpathogenic or engineered to be safe by specific genetic deletions yet retain the ability to infect and kill human cancer cells and elicit anticancer immunity. Some versions are being specifically designed and tested in patients with osteosarcoma, though due to their generalized mechanism of action most are being tested in patients across a broad range of cancer types. The activity of these viruses is impacted not only by the susceptibility of tumor cells to infection but also by the tumor microenvironment (TME) and by tumor immunogenicity. Here we review the field of oncolytic viruses with a particular emphasis on highlighting any available data in preclinical osteosarcoma models or in patients with osteosarcoma. While in general the viruses have been shown safe to administer to patients by a variety of routes, their therapeutic efficacy to date has been limited. Given the low rate of adverse events and the likely absence of long-term side effects, the utility of oncolytic viruses will most likely be realized when used in combination with other agents." @default.
- W3048308846 created "2020-08-13" @default.
- W3048308846 creator A5005634440 @default.
- W3048308846 creator A5017250643 @default.
- W3048308846 date "2020-01-01" @default.
- W3048308846 modified "2023-10-16" @default.
- W3048308846 title "Oncolytic Viruses and Their Potential as a Therapeutic Opportunity in Osteosarcoma" @default.
- W3048308846 cites W1481410803 @default.
- W3048308846 cites W1516165216 @default.
- W3048308846 cites W1590408437 @default.
- W3048308846 cites W1926460199 @default.
- W3048308846 cites W1934455124 @default.
- W3048308846 cites W1970646995 @default.
- W3048308846 cites W1979702687 @default.
- W3048308846 cites W1980232725 @default.
- W3048308846 cites W1988967544 @default.
- W3048308846 cites W2000971601 @default.
- W3048308846 cites W2001405744 @default.
- W3048308846 cites W2002726776 @default.
- W3048308846 cites W2004630197 @default.
- W3048308846 cites W2009720434 @default.
- W3048308846 cites W2010256904 @default.
- W3048308846 cites W2012611138 @default.
- W3048308846 cites W2016080258 @default.
- W3048308846 cites W2022516432 @default.
- W3048308846 cites W2026066964 @default.
- W3048308846 cites W2031655219 @default.
- W3048308846 cites W2034901529 @default.
- W3048308846 cites W203672238 @default.
- W3048308846 cites W2037166403 @default.
- W3048308846 cites W2039084800 @default.
- W3048308846 cites W2044700629 @default.
- W3048308846 cites W2047477932 @default.
- W3048308846 cites W2049352377 @default.
- W3048308846 cites W2049553585 @default.
- W3048308846 cites W2056158873 @default.
- W3048308846 cites W2060281448 @default.
- W3048308846 cites W2063512646 @default.
- W3048308846 cites W2070510018 @default.
- W3048308846 cites W2073134590 @default.
- W3048308846 cites W2077783814 @default.
- W3048308846 cites W2080543048 @default.
- W3048308846 cites W2082150850 @default.
- W3048308846 cites W2086384625 @default.
- W3048308846 cites W2093297340 @default.
- W3048308846 cites W2093382343 @default.
- W3048308846 cites W2094109076 @default.
- W3048308846 cites W2096783631 @default.
- W3048308846 cites W2098521139 @default.
- W3048308846 cites W2100367218 @default.
- W3048308846 cites W2101058247 @default.
- W3048308846 cites W2104630046 @default.
- W3048308846 cites W2108595427 @default.
- W3048308846 cites W2109274792 @default.
- W3048308846 cites W2110592777 @default.
- W3048308846 cites W2112136138 @default.
- W3048308846 cites W2121451608 @default.
- W3048308846 cites W2126731227 @default.
- W3048308846 cites W2133962584 @default.
- W3048308846 cites W2135686776 @default.
- W3048308846 cites W2135835344 @default.
- W3048308846 cites W2148232342 @default.
- W3048308846 cites W2174333513 @default.
- W3048308846 cites W2178480334 @default.
- W3048308846 cites W2290842325 @default.
- W3048308846 cites W2316101052 @default.
- W3048308846 cites W2316543256 @default.
- W3048308846 cites W2321353263 @default.
- W3048308846 cites W2324106738 @default.
- W3048308846 cites W2324558170 @default.
- W3048308846 cites W2338576144 @default.
- W3048308846 cites W2412327310 @default.
- W3048308846 cites W2462404813 @default.
- W3048308846 cites W2491306389 @default.
- W3048308846 cites W2589751944 @default.
- W3048308846 cites W2602691345 @default.
- W3048308846 cites W2606495925 @default.
- W3048308846 cites W2612912395 @default.
- W3048308846 cites W2616230058 @default.
- W3048308846 cites W2618764609 @default.
- W3048308846 cites W2624408765 @default.
- W3048308846 cites W2624782256 @default.
- W3048308846 cites W2765998971 @default.
- W3048308846 cites W2766090242 @default.
- W3048308846 cites W2766948837 @default.
- W3048308846 cites W2767250204 @default.
- W3048308846 cites W2774372124 @default.
- W3048308846 cites W2790684563 @default.
- W3048308846 cites W2793196876 @default.
- W3048308846 cites W2800862488 @default.
- W3048308846 cites W2807729510 @default.
- W3048308846 cites W2884667904 @default.
- W3048308846 cites W2890342567 @default.
- W3048308846 cites W2892650455 @default.
- W3048308846 cites W2897118246 @default.
- W3048308846 cites W2901585058 @default.
- W3048308846 cites W2907468621 @default.
- W3048308846 cites W2909679049 @default.