FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048314393> ?p ?o ?g. }

• W3048314393 abstract "<h3>Purpose</h3> In the event of an acute ischemic stroke due to large vessel occlusion (AIS-LVO), patients with large core infarction and malignant edema have worse outcomes. Core infarction size growth is caused by poor cerebral blood flow and impaired microvascular perfusion. Cerebral microvascular perfusion is governed by the in-flow of arterial blood to the brain tissue, but also likely by the outflow of blood through the cerebral veins. Venous blood flow in the context of AIS-LVO may better indicate the the overall quality of tissue perfusion, as it reflects blood flow after passing the brain tissue. We determined if the venous microperfusion profile (VMP) predict ischemic lesion growth and final infarct core in AIS-LVO patients. <h3>Materials and Methods</h3> We performed a multicenter, retrospective cohort study of AIS-LVO patients undergoing thrombectomy triage with CT angiography (CTA) and CT perfusion (CTP). Patients with motion artifact and incomplete electronical medical data were excluded. Patient details were obtained from prospectively maintained stroke databases and the electronic medical record. VMP was determined by opacification of the vein of Labbé, sphenoparietal sinus, and superficial middle cerebral vein on pre-thrombectomy CTA as: 0, not visible; 1, moderate opacification; and 2, full. Brain edema progression and infarct growth as assessed by Net Water Uptake (NWU), which was calculated on pre-treatment and post-thrombectomy non contrast computed tomography images using manual regions of interest. Primary outcome measure was ischemic lesion growth after thrombectomy. Secondary outcome was final core infarction volume, which was manually segmented on follow-up CT and MRI studies 24–48 hours after thrombectomy. <h3>Results</h3> 250 patients met inclusion criteria. Median patient age was 76 (IQR 65–82). 50% were female. Linear regression models found that increased patient age (p=0.011), higher blood glucose levels (p=0.007), lower TICI scores (p<0.001) and reduced VMP (p<0.001) predicted increased core infarction growth (higher NWU). In a multivariate regression analysis, poor VMP predicted core infarct growth while controlling for age, blood glucose, and TICI score (β=-2.111840, [ 95% CI-2.808059256 -1.41562150]; p<001). In a secondary analysis focused on final infarct core, we excluded 5 patients due to missing final infarct size data. After controlling for age, blood glucose, and TICI score, poor VMP predicted higher final core infarct size (β= -22.57626,[ 95% CI -30.7799325 -14.3725813]; p<001). <h3>Conclusion</h3> Poor cerebral perfusion on the venous microvascular profile predicts ischemic lesion growth and final infarct core volume in AIS-LVO patients treated with thrombectomy. <h3>Disclosures</h3> <b>T. Faizy:</b> None. <b>R. Kabiri:</b> None. <b>M. Leipzig:</b> None. <b>G. Broocks:</b> None. <b>S. Christensen:</b> None. <b>F. Flottmann:</b> None. <b>M. Lansberg:</b> None. <b>G. Albers:</b> None. <b>J. Fiehler:</b> None. <b>M. Wintermark:</b> None. <b>J. Heit:</b> None." @default.
• W3048314393 created "2020-08-13" @default.
• W3048314393 creator A5000895141 @default.
• W3048314393 creator A5000937822 @default.
• W3048314393 creator A5009601688 @default.
• W3048314393 creator A5024460519 @default.
• W3048314393 creator A5034948908 @default.
• W3048314393 creator A5036035553 @default.
• W3048314393 creator A5052087773 @default.
• W3048314393 creator A5058748052 @default.
• W3048314393 creator A5061175108 @default.
• W3048314393 creator A5079031814 @default.
• W3048314393 creator A5081378589 @default.
• W3048314393 date "2020-08-01" @default.
• W3048314393 modified "2023-10-18" @default.
• W3048314393 title "O-027 Favorable venous microvascular profile is associated with smaller ischemic lesion growth and smaller final core infarction volume in patients with acute ischemic stroke due to large vessel occlusion" @default.
• W3048314393 doi "https://doi.org/10.1136/neurintsurg-2020-snis.27" @default.
• W3048314393 hasPublicationYear "2020" @default.
• W3048314393 type Work @default.
• W3048314393 sameAs 3048314393 @default.
• W3048314393 citedByCount "0" @default.
• W3048314393 crossrefType "proceedings-article" @default.
• W3048314393 hasAuthorship W3048314393A5000895141 @default.
• W3048314393 hasAuthorship W3048314393A5000937822 @default.
• W3048314393 hasAuthorship W3048314393A5009601688 @default.
• W3048314393 hasAuthorship W3048314393A5024460519 @default.
• W3048314393 hasAuthorship W3048314393A5034948908 @default.
• W3048314393 hasAuthorship W3048314393A5036035553 @default.
• W3048314393 hasAuthorship W3048314393A5052087773 @default.
• W3048314393 hasAuthorship W3048314393A5058748052 @default.
• W3048314393 hasAuthorship W3048314393A5061175108 @default.
• W3048314393 hasAuthorship W3048314393A5079031814 @default.
• W3048314393 hasAuthorship W3048314393A5081378589 @default.
• W3048314393 hasBestOaLocation W30483143931 @default.
• W3048314393 hasConcept C126322002 @default.
• W3048314393 hasConcept C126838900 @default.
• W3048314393 hasConcept C127413603 @default.
• W3048314393 hasConcept C135691158 @default.
• W3048314393 hasConcept C146957229 @default.
• W3048314393 hasConcept C151730666 @default.
• W3048314393 hasConcept C157767197 @default.
• W3048314393 hasConcept C158846371 @default.
• W3048314393 hasConcept C164705383 @default.
• W3048314393 hasConcept C2776268601 @default.
• W3048314393 hasConcept C2777798775 @default.
• W3048314393 hasConcept C2779343474 @default.
• W3048314393 hasConcept C2779450755 @default.
• W3048314393 hasConcept C2780577055 @default.
• W3048314393 hasConcept C2780643987 @default.
• W3048314393 hasConcept C2780645631 @default.
• W3048314393 hasConcept C500558357 @default.
• W3048314393 hasConcept C541997718 @default.
• W3048314393 hasConcept C71924100 @default.
• W3048314393 hasConcept C78519656 @default.
• W3048314393 hasConcept C86803240 @default.
• W3048314393 hasConceptScore W3048314393C126322002 @default.
• W3048314393 hasConceptScore W3048314393C126838900 @default.
• W3048314393 hasConceptScore W3048314393C127413603 @default.
• W3048314393 hasConceptScore W3048314393C135691158 @default.
• W3048314393 hasConceptScore W3048314393C146957229 @default.
• W3048314393 hasConceptScore W3048314393C151730666 @default.
• W3048314393 hasConceptScore W3048314393C157767197 @default.
• W3048314393 hasConceptScore W3048314393C158846371 @default.
• W3048314393 hasConceptScore W3048314393C164705383 @default.
• W3048314393 hasConceptScore W3048314393C2776268601 @default.
• W3048314393 hasConceptScore W3048314393C2777798775 @default.
• W3048314393 hasConceptScore W3048314393C2779343474 @default.
• W3048314393 hasConceptScore W3048314393C2779450755 @default.
• W3048314393 hasConceptScore W3048314393C2780577055 @default.
• W3048314393 hasConceptScore W3048314393C2780643987 @default.
• W3048314393 hasConceptScore W3048314393C2780645631 @default.
• W3048314393 hasConceptScore W3048314393C500558357 @default.
• W3048314393 hasConceptScore W3048314393C541997718 @default.
• W3048314393 hasConceptScore W3048314393C71924100 @default.
• W3048314393 hasConceptScore W3048314393C78519656 @default.
• W3048314393 hasConceptScore W3048314393C86803240 @default.
• W3048314393 hasLocation W30483143931 @default.
• W3048314393 hasOpenAccess W3048314393 @default.
• W3048314393 hasPrimaryLocation W30483143931 @default.
• W3048314393 hasRelatedWork W2352289526 @default.
• W3048314393 hasRelatedWork W2354437714 @default.
• W3048314393 hasRelatedWork W2354637087 @default.
• W3048314393 hasRelatedWork W2355033307 @default.
• W3048314393 hasRelatedWork W2374215347 @default.
• W3048314393 hasRelatedWork W2380593462 @default.
• W3048314393 hasRelatedWork W2388107658 @default.
• W3048314393 hasRelatedWork W2390050192 @default.
• W3048314393 hasRelatedWork W3030085139 @default.
• W3048314393 hasRelatedWork W3030939712 @default.
• W3048314393 isParatext "false" @default.
• W3048314393 isRetracted "false" @default.
• W3048314393 magId "3048314393" @default.
• W3048314393 workType "article" @default.