Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048315078> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3048315078 abstract "Abstract Objectives To improve understanding of transition from viral infection to viral clearance, and antibody response in pediatric patients with SARS-CoV-2 infection. Study design This retrospective analysis of children tested for SARS-CoV-2 by RT-PCR and IgG antibody at a quaternary-care, free-standing pediatric hospital between March 13 th , 2020 to June 21 st , 2020 included 6369 patients who underwent PCR testing and 215 patients who underwent antibody testing. During the initial study period, testing focused primarily on symptomatic children; the later study period included asymptomatic patients who underwent testing as preadmission or preprocedural screening. We report the proportion of positive and negative tests, time to viral clearance, and time to seropositivity. Results The rate of positivity varied over time due to viral circulation in the community and transition from targeted testing of symptomatic patients to more universal screening of hospitalized patients. Median duration of viral shedding (RT-PCR positivity) was 19.5 days and RT-PCR negativity from positivity was 25 days. Of note, patients aged 6 to 15 years demonstrated a longer period of RT-PCR negativity from positivity, compared to patients aged 16 to 22 years (median=32 versus 18 days, p=0.015). Median time to seropositivity from RT-PCR positivity was 18 days while median time to reach adequate levels of neutralizing antibodies (defined as equivalent to 160 titer) was 36 days. Conclusions The majority of patients demonstrated a prolonged period of viral shedding after infection with SARS CoV-2. Whether this correlates with persistent infectivity is unknown. Only 17 of 33 patients demonstrated neutralizing antibodies, suggesting that some patients may not mount significant immune responses to infection. It remains unknown if IgG antibody production correlates with immunity and how long measurable antibodies persist and protect against future infection." @default.
- W3048315078 created "2020-08-13" @default.
- W3048315078 creator A5015395079 @default.
- W3048315078 creator A5029674721 @default.
- W3048315078 creator A5065585077 @default.
- W3048315078 creator A5069664128 @default.
- W3048315078 creator A5070648034 @default.
- W3048315078 creator A5080853505 @default.
- W3048315078 date "2020-08-07" @default.
- W3048315078 modified "2023-09-25" @default.
- W3048315078 title "Kinetics of viral clearance and antibody production across age groups in SARS-CoV-2 infected children" @default.
- W3048315078 cites W1662940398 @default.
- W3048315078 cites W1963838989 @default.
- W3048315078 cites W2161428851 @default.
- W3048315078 cites W2564443324 @default.
- W3048315078 cites W2886321229 @default.
- W3048315078 cites W3001456238 @default.
- W3048315078 cites W3004280078 @default.
- W3048315078 cites W3008142620 @default.
- W3048315078 cites W3009885589 @default.
- W3048315078 cites W3010819577 @default.
- W3048315078 cites W3012435540 @default.
- W3048315078 cites W3012756997 @default.
- W3048315078 cites W3013891156 @default.
- W3048315078 cites W3014067025 @default.
- W3048315078 cites W3017817496 @default.
- W3048315078 cites W3021274772 @default.
- W3048315078 cites W3022835607 @default.
- W3048315078 cites W3025141218 @default.
- W3048315078 cites W3025444323 @default.
- W3048315078 cites W3026409241 @default.
- W3048315078 cites W3028468499 @default.
- W3048315078 cites W3032051189 @default.
- W3048315078 cites W3032810375 @default.
- W3048315078 cites W3033900100 @default.
- W3048315078 cites W3037151855 @default.
- W3048315078 cites W3119866784 @default.
- W3048315078 doi "https://doi.org/10.1101/2020.08.06.20162446" @default.
- W3048315078 hasPublicationYear "2020" @default.
- W3048315078 type Work @default.
- W3048315078 sameAs 3048315078 @default.
- W3048315078 citedByCount "1" @default.
- W3048315078 countsByYear W30483150782022 @default.
- W3048315078 crossrefType "posted-content" @default.
- W3048315078 hasAuthorship W3048315078A5015395079 @default.
- W3048315078 hasAuthorship W3048315078A5029674721 @default.
- W3048315078 hasAuthorship W3048315078A5065585077 @default.
- W3048315078 hasAuthorship W3048315078A5069664128 @default.
- W3048315078 hasAuthorship W3048315078A5070648034 @default.
- W3048315078 hasAuthorship W3048315078A5080853505 @default.
- W3048315078 hasBestOaLocation W30483150781 @default.
- W3048315078 hasConcept C126322002 @default.
- W3048315078 hasConcept C12914427 @default.
- W3048315078 hasConcept C142462285 @default.
- W3048315078 hasConcept C156725737 @default.
- W3048315078 hasConcept C159654299 @default.
- W3048315078 hasConcept C203014093 @default.
- W3048315078 hasConcept C22889606 @default.
- W3048315078 hasConcept C2522874641 @default.
- W3048315078 hasConcept C2777910003 @default.
- W3048315078 hasConcept C2779134260 @default.
- W3048315078 hasConcept C3007834351 @default.
- W3048315078 hasConcept C3008058167 @default.
- W3048315078 hasConcept C32611913 @default.
- W3048315078 hasConcept C524204448 @default.
- W3048315078 hasConcept C71924100 @default.
- W3048315078 hasConcept C90924648 @default.
- W3048315078 hasConceptScore W3048315078C126322002 @default.
- W3048315078 hasConceptScore W3048315078C12914427 @default.
- W3048315078 hasConceptScore W3048315078C142462285 @default.
- W3048315078 hasConceptScore W3048315078C156725737 @default.
- W3048315078 hasConceptScore W3048315078C159654299 @default.
- W3048315078 hasConceptScore W3048315078C203014093 @default.
- W3048315078 hasConceptScore W3048315078C22889606 @default.
- W3048315078 hasConceptScore W3048315078C2522874641 @default.
- W3048315078 hasConceptScore W3048315078C2777910003 @default.
- W3048315078 hasConceptScore W3048315078C2779134260 @default.
- W3048315078 hasConceptScore W3048315078C3007834351 @default.
- W3048315078 hasConceptScore W3048315078C3008058167 @default.
- W3048315078 hasConceptScore W3048315078C32611913 @default.
- W3048315078 hasConceptScore W3048315078C524204448 @default.
- W3048315078 hasConceptScore W3048315078C71924100 @default.
- W3048315078 hasConceptScore W3048315078C90924648 @default.
- W3048315078 hasLocation W30483150781 @default.
- W3048315078 hasOpenAccess W3048315078 @default.
- W3048315078 hasPrimaryLocation W30483150781 @default.
- W3048315078 hasRelatedWork W2016073315 @default.
- W3048315078 hasRelatedWork W2097778920 @default.
- W3048315078 hasRelatedWork W2355850052 @default.
- W3048315078 hasRelatedWork W3016385790 @default.
- W3048315078 hasRelatedWork W3018485916 @default.
- W3048315078 hasRelatedWork W3024093150 @default.
- W3048315078 hasRelatedWork W3047644361 @default.
- W3048315078 hasRelatedWork W3120212630 @default.
- W3048315078 hasRelatedWork W3212738146 @default.
- W3048315078 hasRelatedWork W4281684902 @default.
- W3048315078 isParatext "false" @default.
- W3048315078 isRetracted "false" @default.
- W3048315078 magId "3048315078" @default.
- W3048315078 workType "article" @default.