Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048317245> ?p ?o ?g. }
- W3048317245 endingPage "1350" @default.
- W3048317245 startingPage "1343" @default.
- W3048317245 abstract "The adhesion G-protein-coupled receptor (GPCR) latrophilin 3 (ADGRL3) has been associated with increased risk of attention deficit hyperactivity disorder (ADHD) and substance use in human genetic studies. Knockdown in multiple species leads to hyperlocomotion and altered dopamine signaling. Thus, ADGRL3 is a potential target for treatment of neuropsychiatric disorders that involve dopamine dysfunction, but its basic signaling properties are poorly understood. Identification of adhesion GPCR signaling partners has been limited by a lack of tools to acutely activate these receptors in living cells. Here, we design a novel acute activation strategy to characterize ADGRL3 signaling by engineering a receptor construct in which we could trigger acute activation enzymatically. Using this assay, we found that ADGRL3 signals through G12/G13 and Gq, with G12/13 the most robustly activated. Gα12/13 is a new player in ADGRL3 biology, opening up unexplored roles for ADGRL3 in the brain. Our methodological advancements should be broadly useful in adhesion GPCR research." @default.
- W3048317245 created "2020-08-13" @default.
- W3048317245 creator A5004277635 @default.
- W3048317245 creator A5011432625 @default.
- W3048317245 creator A5032316956 @default.
- W3048317245 creator A5035897723 @default.
- W3048317245 creator A5036686598 @default.
- W3048317245 creator A5039694418 @default.
- W3048317245 creator A5053467850 @default.
- W3048317245 creator A5057973936 @default.
- W3048317245 creator A5064271527 @default.
- W3048317245 creator A5064921157 @default.
- W3048317245 creator A5069843032 @default.
- W3048317245 creator A5077336005 @default.
- W3048317245 date "2020-08-10" @default.
- W3048317245 modified "2023-10-14" @default.
- W3048317245 title "G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3" @default.
- W3048317245 cites W1212063835 @default.
- W3048317245 cites W1581369687 @default.
- W3048317245 cites W1875939621 @default.
- W3048317245 cites W1964871373 @default.
- W3048317245 cites W1974052300 @default.
- W3048317245 cites W1977789280 @default.
- W3048317245 cites W1980022376 @default.
- W3048317245 cites W1984875318 @default.
- W3048317245 cites W1992151784 @default.
- W3048317245 cites W1995016025 @default.
- W3048317245 cites W1995852110 @default.
- W3048317245 cites W1997729758 @default.
- W3048317245 cites W2006031720 @default.
- W3048317245 cites W2010441615 @default.
- W3048317245 cites W2021218920 @default.
- W3048317245 cites W2035123506 @default.
- W3048317245 cites W2035447817 @default.
- W3048317245 cites W2047581892 @default.
- W3048317245 cites W2051852715 @default.
- W3048317245 cites W2064433020 @default.
- W3048317245 cites W2075536398 @default.
- W3048317245 cites W2099540110 @default.
- W3048317245 cites W2103209594 @default.
- W3048317245 cites W2111689719 @default.
- W3048317245 cites W2113241039 @default.
- W3048317245 cites W2128870952 @default.
- W3048317245 cites W2138530853 @default.
- W3048317245 cites W2144246125 @default.
- W3048317245 cites W2146928658 @default.
- W3048317245 cites W2159319913 @default.
- W3048317245 cites W2184364461 @default.
- W3048317245 cites W2217674194 @default.
- W3048317245 cites W2239632319 @default.
- W3048317245 cites W2302389802 @default.
- W3048317245 cites W2472354124 @default.
- W3048317245 cites W2557016000 @default.
- W3048317245 cites W2588374458 @default.
- W3048317245 cites W2592331661 @default.
- W3048317245 cites W2742439855 @default.
- W3048317245 cites W2785756218 @default.
- W3048317245 cites W2790810217 @default.
- W3048317245 cites W2792615468 @default.
- W3048317245 cites W2792983781 @default.
- W3048317245 cites W2799552888 @default.
- W3048317245 cites W2802667423 @default.
- W3048317245 cites W2911504902 @default.
- W3048317245 cites W2912254443 @default.
- W3048317245 cites W2916366474 @default.
- W3048317245 cites W2933103205 @default.
- W3048317245 cites W2947163054 @default.
- W3048317245 cites W2951502369 @default.
- W3048317245 cites W2982692052 @default.
- W3048317245 cites W3015639365 @default.
- W3048317245 cites W911753804 @default.
- W3048317245 doi "https://doi.org/10.1038/s41589-020-0617-7" @default.
- W3048317245 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7990041" @default.
- W3048317245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32778842" @default.
- W3048317245 hasPublicationYear "2020" @default.
- W3048317245 type Work @default.
- W3048317245 sameAs 3048317245 @default.
- W3048317245 citedByCount "35" @default.
- W3048317245 countsByYear W30483172452020 @default.
- W3048317245 countsByYear W30483172452021 @default.
- W3048317245 countsByYear W30483172452022 @default.
- W3048317245 countsByYear W30483172452023 @default.
- W3048317245 crossrefType "journal-article" @default.
- W3048317245 hasAuthorship W3048317245A5004277635 @default.
- W3048317245 hasAuthorship W3048317245A5011432625 @default.
- W3048317245 hasAuthorship W3048317245A5032316956 @default.
- W3048317245 hasAuthorship W3048317245A5035897723 @default.
- W3048317245 hasAuthorship W3048317245A5036686598 @default.
- W3048317245 hasAuthorship W3048317245A5039694418 @default.
- W3048317245 hasAuthorship W3048317245A5053467850 @default.
- W3048317245 hasAuthorship W3048317245A5057973936 @default.
- W3048317245 hasAuthorship W3048317245A5064271527 @default.
- W3048317245 hasAuthorship W3048317245A5064921157 @default.
- W3048317245 hasAuthorship W3048317245A5069843032 @default.
- W3048317245 hasAuthorship W3048317245A5077336005 @default.
- W3048317245 hasBestOaLocation W30483172452 @default.
- W3048317245 hasConcept C135285700 @default.
- W3048317245 hasConcept C169760540 @default.