Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048328342> ?p ?o ?g. }
- W3048328342 abstract "Osteopontin (OPN) is involved in ectopic calcification. Its circulating form is upregulated in coronary artery disease (CAD) patients. Circulating OPN levels positively correlate with oxidative stress, one of the major triggers of endothelial dysfunction. Endothelial dysfunction is, in turn, associated with reduced nitric oxide (NO) bioavailability due to the impaired arginine pathway. The aim of this study was to better understand the correlations between OPN, oxidative stress markers, and the arginine pathway metabolites.ELISA and mass spectrometry techniques have been used to evaluate circulating OPN and arginine pathway/oxidative stress metabolites, respectively, in twenty-five control subjects and thirty-three patients with overt atherosclerosis. OPN positively correlates with 2,3-dinor-8isoPGF2a levels (p = 0.02), ornithine (p = 0.01), ADMA (p = 0.001), SDMA (p = 0.03), and citrulline (p = 0.008) levels only in CAD patients. In addition, citrulline positively correlated with ADMA (p = 0.02) levels, possibly as result of other sources of citrulline biosynthetic pathways.The association between OPN and impaired arginine/NO pathway could play a role in the inhibition of endothelial NO synthase (eNOS) and/or in the arginase activation in the context of CAD patients. However, further studies are needed to verify the cause-effect relationship between OPN, oxidative stress, and arginine/NO pathway dysregulation." @default.
- W3048328342 created "2020-08-13" @default.
- W3048328342 creator A5001770956 @default.
- W3048328342 creator A5011643232 @default.
- W3048328342 creator A5012710359 @default.
- W3048328342 creator A5027397773 @default.
- W3048328342 creator A5030257967 @default.
- W3048328342 creator A5033336714 @default.
- W3048328342 creator A5052806409 @default.
- W3048328342 creator A5065230538 @default.
- W3048328342 creator A5069796103 @default.
- W3048328342 creator A5073001267 @default.
- W3048328342 creator A5079534687 @default.
- W3048328342 creator A5084094886 @default.
- W3048328342 creator A5089166046 @default.
- W3048328342 date "2020-08-06" @default.
- W3048328342 modified "2023-10-18" @default.
- W3048328342 title "Relationship Between Plasma Osteopontin and Arginine Pathway Metabolites in Patients With Overt Coronary Artery Disease" @default.
- W3048328342 cites W1618037986 @default.
- W3048328342 cites W1973957009 @default.
- W3048328342 cites W1988051579 @default.
- W3048328342 cites W1998274854 @default.
- W3048328342 cites W2002967273 @default.
- W3048328342 cites W2004322312 @default.
- W3048328342 cites W2006965746 @default.
- W3048328342 cites W2008201148 @default.
- W3048328342 cites W2021415784 @default.
- W3048328342 cites W2021436833 @default.
- W3048328342 cites W2049292864 @default.
- W3048328342 cites W2049965331 @default.
- W3048328342 cites W2052006449 @default.
- W3048328342 cites W2055237682 @default.
- W3048328342 cites W2070194830 @default.
- W3048328342 cites W2073485308 @default.
- W3048328342 cites W2080539318 @default.
- W3048328342 cites W2136007951 @default.
- W3048328342 cites W2137727884 @default.
- W3048328342 cites W2147854469 @default.
- W3048328342 cites W2149906460 @default.
- W3048328342 cites W2155696208 @default.
- W3048328342 cites W2159571285 @default.
- W3048328342 cites W2163652382 @default.
- W3048328342 cites W2165753570 @default.
- W3048328342 cites W2166947330 @default.
- W3048328342 cites W2404553872 @default.
- W3048328342 cites W2516159575 @default.
- W3048328342 cites W2519262725 @default.
- W3048328342 cites W2555868191 @default.
- W3048328342 cites W2621371007 @default.
- W3048328342 cites W2841068772 @default.
- W3048328342 cites W2942103884 @default.
- W3048328342 cites W2947633835 @default.
- W3048328342 cites W2952389410 @default.
- W3048328342 cites W2982063249 @default.
- W3048328342 cites W2983279384 @default.
- W3048328342 doi "https://doi.org/10.3389/fphys.2020.00982" @default.
- W3048328342 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7424048" @default.
- W3048328342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32848891" @default.
- W3048328342 hasPublicationYear "2020" @default.
- W3048328342 type Work @default.
- W3048328342 sameAs 3048328342 @default.
- W3048328342 citedByCount "1" @default.
- W3048328342 countsByYear W30483283422022 @default.
- W3048328342 crossrefType "journal-article" @default.
- W3048328342 hasAuthorship W3048328342A5001770956 @default.
- W3048328342 hasAuthorship W3048328342A5011643232 @default.
- W3048328342 hasAuthorship W3048328342A5012710359 @default.
- W3048328342 hasAuthorship W3048328342A5027397773 @default.
- W3048328342 hasAuthorship W3048328342A5030257967 @default.
- W3048328342 hasAuthorship W3048328342A5033336714 @default.
- W3048328342 hasAuthorship W3048328342A5052806409 @default.
- W3048328342 hasAuthorship W3048328342A5065230538 @default.
- W3048328342 hasAuthorship W3048328342A5069796103 @default.
- W3048328342 hasAuthorship W3048328342A5073001267 @default.
- W3048328342 hasAuthorship W3048328342A5079534687 @default.
- W3048328342 hasAuthorship W3048328342A5084094886 @default.
- W3048328342 hasAuthorship W3048328342A5089166046 @default.
- W3048328342 hasBestOaLocation W30483283421 @default.
- W3048328342 hasConcept C126322002 @default.
- W3048328342 hasConcept C134018914 @default.
- W3048328342 hasConcept C164007495 @default.
- W3048328342 hasConcept C185592680 @default.
- W3048328342 hasConcept C2776151105 @default.
- W3048328342 hasConcept C2776796294 @default.
- W3048328342 hasConcept C2777468819 @default.
- W3048328342 hasConcept C2777622882 @default.
- W3048328342 hasConcept C2778213512 @default.
- W3048328342 hasConcept C2778326061 @default.
- W3048328342 hasConcept C2779129087 @default.
- W3048328342 hasConcept C2779877776 @default.
- W3048328342 hasConcept C2780804394 @default.
- W3048328342 hasConcept C2780972559 @default.
- W3048328342 hasConcept C515207424 @default.
- W3048328342 hasConcept C519581460 @default.
- W3048328342 hasConcept C55493867 @default.
- W3048328342 hasConcept C71924100 @default.
- W3048328342 hasConceptScore W3048328342C126322002 @default.
- W3048328342 hasConceptScore W3048328342C134018914 @default.
- W3048328342 hasConceptScore W3048328342C164007495 @default.
- W3048328342 hasConceptScore W3048328342C185592680 @default.