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• W3048331500 abstract "The Siddha Medicine has been in traditional use for years with proven efficacy and to be safe in experience. Karasooda sathu parpam is one of the Siddha medicine indicated for urethritis and urinary tract infections. Karasooda sathu parpam contain Vengaram (Borax) and Silasathu (Selenite).The raw drugs of Karasooda sathu parpam were collected from raw drug store and authenticated at Siddha Central Research Institute. The raw drugs of Karasooda sathu parpam were purified and the medicine was prepared as mentioned in the Siddha literature.Qualitative analysis was confirmed the presence of Sulphate, Calcium, Phosphate, Iron, and Sodium in Vengaram, Silasathu(before and after purification) and Karasooda sathu parpam. The Aluminum and magnesium was present in silasathu(before and after purification).The presence of inorganic elements in Vengaram, Silasathu (before and after purification) and Karasooda sathu parpam were confirmed by ICP OES analysis. The results revealed that there was no heavy metal found in Vengaram, Silasathu (before and after purification) and Karasooda sathu Parpam. The particle size through HR SEM analysis of karasooda sathu parpam was 10 - 50 μ.The toxicological evaluations were conducted as per WHO guidelines for safety evaluation of Poora Parpam.In Acute toxicity study there were no abnormal signs developed in Swiss albino mice at 10 times more than the therapeutic dose level (1.29 mg/animal) within 24 hrs.At the end of the study no mortality and reduction in body weight of control and test group animals were observed.In Long term toxicity study there were no significant changes in behavioral signs, hematological parameters, biochemical investigation, body weight, food and water intake. The lymphocyte count was increased in test groups, but compared with control group it is not statistically significant. The histopathological study on the organs such as heart, kidney, and liver was normal in X and 5 X groups compared with control group. In 10 X group, only the stomach showed focal superficial ulceration in gastric mucosa and the other organs showed no abnormal histological variation.CONCLUSION:The chemical analysis of karasooda sathu parpam revealed presence of important minerals and some alteration in minerals level during preparation.Also the partical size of karasooda sathu parpam is microns in level and surface is smooth and the flowability is easy this can lead to better bioabsorption and efficacy of this medicine.There is no mortality and no toxic signs produced in acute. In long term toxicity study mild changes showed in histological and biochemical parameter at the dose level of12.2 mg/ animal and reveals that different doses of drug does not cause any changes in hematological parameters.Hence, the karasooda sathu parpam couldn’t produce any toxicity in therapeutic dose. So the therapeutic dose level mentioned in the literature is may be safe and it can beconculuded that the karasooda sathu parpam can be used in clinically." @default.
• W3048331500 created "2020-08-13" @default.
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• W3048331500 date "2012-04-01" @default.
• W3048331500 modified "2023-09-23" @default.
• W3048331500 title "Preclinical Toxicity study on Karasooda Sathu Parpam" @default.
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