Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048334191> ?p ?o ?g. }
- W3048334191 endingPage "3438" @default.
- W3048334191 startingPage "3423" @default.
- W3048334191 abstract "Abstract This research dealt with the multicomponent crystal developed from diclofenac potassium and l -proline to improve the pharmaceutical performance of this anti-inflammatory drug. Slow evaporation of the component mixture at a 1:1 M ratio, supported by ultrasonication, yielded a new salt cocrystal, which was characterized using thermal analysis, Karl Fischer titration, infrared spectrophotometry, powder diffractometry, and single crystal diffractometry. This salt cocrystal was confirmed as a tetrahydrate that comprised diclofenac potassium, l -proline, and water (1:1:4), named DKPH. The new salt cocrystal enhanced the solubility of diclofenac potassium by up to 3.56 folds and accelerated the intrinsic dissolution rate of 3.36 folds. It was supported by the solid and solution phase intermolecular interaction study. A different phase, which indicated a monohydrate form of the salt cocrystal, was found from the low humidity chamber during the isotherm sorption study. However, the tetrahydrate, DKPH, was proven as a stable form under ambient conditions." @default.
- W3048334191 created "2020-08-13" @default.
- W3048334191 creator A5005568921 @default.
- W3048334191 creator A5042194657 @default.
- W3048334191 creator A5082493394 @default.
- W3048334191 creator A5086800033 @default.
- W3048334191 date "2020-11-01" @default.
- W3048334191 modified "2023-10-17" @default.
- W3048334191 title "Composing Novel Diclofenac Potassium and l-Proline Salt Cocrystal as a Strategy to Increase Solubility and Dissolution" @default.
- W3048334191 cites W1964145831 @default.
- W3048334191 cites W1978360892 @default.
- W3048334191 cites W1986631729 @default.
- W3048334191 cites W1990165855 @default.
- W3048334191 cites W2006320900 @default.
- W3048334191 cites W2008894253 @default.
- W3048334191 cites W2010854760 @default.
- W3048334191 cites W2025152757 @default.
- W3048334191 cites W2025754515 @default.
- W3048334191 cites W2028466397 @default.
- W3048334191 cites W2036018205 @default.
- W3048334191 cites W2058896357 @default.
- W3048334191 cites W2067129640 @default.
- W3048334191 cites W2068984440 @default.
- W3048334191 cites W2072580290 @default.
- W3048334191 cites W2078799368 @default.
- W3048334191 cites W2089828431 @default.
- W3048334191 cites W2094908453 @default.
- W3048334191 cites W2114269481 @default.
- W3048334191 cites W2117669255 @default.
- W3048334191 cites W2145227775 @default.
- W3048334191 cites W2161607570 @default.
- W3048334191 cites W2165532680 @default.
- W3048334191 cites W2168330215 @default.
- W3048334191 cites W2170170812 @default.
- W3048334191 cites W2270927172 @default.
- W3048334191 cites W2302505094 @default.
- W3048334191 cites W2333448697 @default.
- W3048334191 cites W2333823060 @default.
- W3048334191 cites W2345796899 @default.
- W3048334191 cites W2486046770 @default.
- W3048334191 cites W255808519 @default.
- W3048334191 cites W2586729607 @default.
- W3048334191 cites W2599801457 @default.
- W3048334191 cites W2603296199 @default.
- W3048334191 cites W2613887060 @default.
- W3048334191 cites W2619821040 @default.
- W3048334191 cites W2631638363 @default.
- W3048334191 cites W2759590287 @default.
- W3048334191 cites W2772425515 @default.
- W3048334191 cites W2785557395 @default.
- W3048334191 cites W2789088075 @default.
- W3048334191 cites W2792883601 @default.
- W3048334191 cites W2887536982 @default.
- W3048334191 cites W2899264229 @default.
- W3048334191 cites W2908998004 @default.
- W3048334191 cites W2922107415 @default.
- W3048334191 cites W2969876977 @default.
- W3048334191 cites W2994536017 @default.
- W3048334191 cites W4238503328 @default.
- W3048334191 cites W4245966879 @default.
- W3048334191 doi "https://doi.org/10.1016/j.xphs.2020.08.002" @default.
- W3048334191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32777219" @default.
- W3048334191 hasPublicationYear "2020" @default.
- W3048334191 type Work @default.
- W3048334191 sameAs 3048334191 @default.
- W3048334191 citedByCount "12" @default.
- W3048334191 countsByYear W30483341912021 @default.
- W3048334191 countsByYear W30483341912022 @default.
- W3048334191 countsByYear W30483341912023 @default.
- W3048334191 crossrefType "journal-article" @default.
- W3048334191 hasAuthorship W3048334191A5005568921 @default.
- W3048334191 hasAuthorship W3048334191A5042194657 @default.
- W3048334191 hasAuthorship W3048334191A5082493394 @default.
- W3048334191 hasAuthorship W3048334191A5086800033 @default.
- W3048334191 hasConcept C100687433 @default.
- W3048334191 hasConcept C112887158 @default.
- W3048334191 hasConcept C13965031 @default.
- W3048334191 hasConcept C155574463 @default.
- W3048334191 hasConcept C178790620 @default.
- W3048334191 hasConcept C179104552 @default.
- W3048334191 hasConcept C185592680 @default.
- W3048334191 hasConcept C2776371256 @default.
- W3048334191 hasConcept C2779815552 @default.
- W3048334191 hasConcept C2779826273 @default.
- W3048334191 hasConcept C32909587 @default.
- W3048334191 hasConcept C515207424 @default.
- W3048334191 hasConcept C517785266 @default.
- W3048334191 hasConcept C55493867 @default.
- W3048334191 hasConcept C71924100 @default.
- W3048334191 hasConcept C88380143 @default.
- W3048334191 hasConcept C98274493 @default.
- W3048334191 hasConceptScore W3048334191C100687433 @default.
- W3048334191 hasConceptScore W3048334191C112887158 @default.
- W3048334191 hasConceptScore W3048334191C13965031 @default.
- W3048334191 hasConceptScore W3048334191C155574463 @default.
- W3048334191 hasConceptScore W3048334191C178790620 @default.
- W3048334191 hasConceptScore W3048334191C179104552 @default.
- W3048334191 hasConceptScore W3048334191C185592680 @default.