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- W3048339453 endingPage "1703" @default.
- W3048339453 startingPage "1703" @default.
- W3048339453 abstract "Epithelial ovarian cancer (EOC) is probably the tumor type with the highest percentage of hereditary cases observed, irrespectively of selection criteria. A fourth to a fifth of unselected epithelial EOC patients carry pathogenic variants (PVs) in a number of genes, the majority of which encode for proteins involved in DNA repair pathways. BRCA1 and BRCA2 predisposing PVs were the first to be associated to ovarian cancer, with the advent in DNA sequencing technologies leading to the discovery and association of additional genes which compromise the homologous recombination (HR) pathway. In addition, PVs genes involved in mismatch repair (MMR) pathway, account for 10-15% of hereditary EOC. The identification of women with HR deficient ovarian cancers has significant clinical implications concerning chemotherapy regimen planning and development and use of targeted therapies as well. More specifically, in patients with BRCA1/2 PVs or HR deficiency maintenance treatment with poly(ADP-ribose) polymerase (PARP) inhibitors, either in the first line setting or in recurrent disease, improves the progression-free survival. But also patients with HR proficient tumors show a benefit. Therefore, genetic testing in ovarian cancer has a prognostic and predictive value. In this review, we discuss which ovarian cancer patients should be referred for genetic counseling and how to perform genetic testing. We also discuss the timing of genetic testing and its clinical relevance to BRCA status." @default.
- W3048339453 created "2020-08-13" @default.
- W3048339453 creator A5005087419 @default.
- W3048339453 creator A5056643910 @default.
- W3048339453 creator A5075859230 @default.
- W3048339453 date "2020-12-01" @default.
- W3048339453 modified "2023-09-30" @default.
- W3048339453 title "Current practices on genetic testing in ovarian cancer" @default.
- W3048339453 cites W1504535992 @default.
- W3048339453 cites W1633875338 @default.
- W3048339453 cites W1926715094 @default.
- W3048339453 cites W1964510578 @default.
- W3048339453 cites W1966928113 @default.
- W3048339453 cites W1968458167 @default.
- W3048339453 cites W1971419576 @default.
- W3048339453 cites W1973268287 @default.
- W3048339453 cites W1976342564 @default.
- W3048339453 cites W1979385111 @default.
- W3048339453 cites W1996737831 @default.
- W3048339453 cites W2001673920 @default.
- W3048339453 cites W2002419036 @default.
- W3048339453 cites W2009007206 @default.
- W3048339453 cites W2012331065 @default.
- W3048339453 cites W2013398180 @default.
- W3048339453 cites W2021743139 @default.
- W3048339453 cites W2029571935 @default.
- W3048339453 cites W2041051519 @default.
- W3048339453 cites W2045733577 @default.
- W3048339453 cites W2054048445 @default.
- W3048339453 cites W2062568878 @default.
- W3048339453 cites W2073988279 @default.
- W3048339453 cites W2086038769 @default.
- W3048339453 cites W2096731080 @default.
- W3048339453 cites W2099000973 @default.
- W3048339453 cites W2100843807 @default.
- W3048339453 cites W2102967423 @default.
- W3048339453 cites W2105908798 @default.
- W3048339453 cites W2106157865 @default.
- W3048339453 cites W2108873448 @default.
- W3048339453 cites W2110143309 @default.
- W3048339453 cites W2117177285 @default.
- W3048339453 cites W2118010724 @default.
- W3048339453 cites W2123113463 @default.
- W3048339453 cites W2123696077 @default.
- W3048339453 cites W2124624490 @default.
- W3048339453 cites W2132600317 @default.
- W3048339453 cites W2135195813 @default.
- W3048339453 cites W2135525536 @default.
- W3048339453 cites W2146274229 @default.
- W3048339453 cites W2152926599 @default.
- W3048339453 cites W2159899668 @default.
- W3048339453 cites W2168804588 @default.
- W3048339453 cites W2169983032 @default.
- W3048339453 cites W2191157318 @default.
- W3048339453 cites W2194014097 @default.
- W3048339453 cites W2224210111 @default.
- W3048339453 cites W2233016591 @default.
- W3048339453 cites W2295474335 @default.
- W3048339453 cites W2296403908 @default.
- W3048339453 cites W2325363292 @default.
- W3048339453 cites W2404782822 @default.
- W3048339453 cites W2414821470 @default.
- W3048339453 cites W2438866487 @default.
- W3048339453 cites W2519148856 @default.
- W3048339453 cites W2528228811 @default.
- W3048339453 cites W2557666746 @default.
- W3048339453 cites W2568126178 @default.
- W3048339453 cites W2594404528 @default.
- W3048339453 cites W2607012627 @default.
- W3048339453 cites W2627871710 @default.
- W3048339453 cites W2704159227 @default.
- W3048339453 cites W2733571990 @default.
- W3048339453 cites W2737389832 @default.
- W3048339453 cites W2749641460 @default.
- W3048339453 cites W2751781882 @default.
- W3048339453 cites W2754327139 @default.
- W3048339453 cites W2766439513 @default.
- W3048339453 cites W2766552679 @default.
- W3048339453 cites W2788103179 @default.
- W3048339453 cites W2788597512 @default.
- W3048339453 cites W2801214434 @default.
- W3048339453 cites W2803852062 @default.
- W3048339453 cites W2807649309 @default.
- W3048339453 cites W2810472611 @default.
- W3048339453 cites W2810781719 @default.
- W3048339453 cites W2886095242 @default.
- W3048339453 cites W2886678486 @default.
- W3048339453 cites W2895926103 @default.
- W3048339453 cites W2897424463 @default.
- W3048339453 cites W2897430921 @default.
- W3048339453 cites W2898845523 @default.
- W3048339453 cites W2945098772 @default.
- W3048339453 cites W2946543583 @default.
- W3048339453 cites W2951438828 @default.
- W3048339453 cites W2952108487 @default.
- W3048339453 cites W2954373146 @default.
- W3048339453 cites W2965145700 @default.
- W3048339453 cites W2970135300 @default.