Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048345636> ?p ?o ?g. }
- W3048345636 endingPage "98" @default.
- W3048345636 startingPage "85" @default.
- W3048345636 abstract "Abstract Spondyloarthritis (SpA) is a common rheumatic disorder of the young, marred by delay in diagnosis, and paucity of biomarkers of disease activity. The present study aimed to explore the potential of serum metabolic profiling of patients with SpA to identify biomarker for the diagnosis and assessment of disease activity. The serum metabolic profiles of 81 patients with SpA were compared with that of 86 healthy controls (HCs) using nuclear magnetic resonance (NMR)‐based metabolomics approach. Seventeen patients were followed up after 3 months of standard treatment, and paired sera were analyzed for effects of therapy. Comparisons were done using the multivariate partial least squares discriminant analysis (PLS‐DA), and the discriminatory metabolic entities were identified based on variable importance in projection (VIP) statistics and further evaluated for statistical significance ( p value < 0.05). We found that the serum metabolic profiles differed significantly in SpA as compared with HCs. Compared with HC, the SpA patients were characterized by increased serum levels of amino acids, acetate, choline, N ‐acetyl glycoproteins, N α‐acetyl lysine, creatine/creatinine, and so forth and decreased levels of low‐/very low‐density lipoproteins and polyunsaturated lipids. PLS‐DA analysis also revealed metabolic differences between axial and peripheral SpA patients. Further metabolite profiles were found to differ with disease activity and treatment in responding patients. The results presented in this study demonstrate the potential of serum metabolic profiling of axial SpA as a useful tool for diagnosis, prediction of peripheral disease, assessment of disease activity, and treatment response." @default.
- W3048345636 created "2020-08-13" @default.
- W3048345636 creator A5004147624 @default.
- W3048345636 creator A5037894792 @default.
- W3048345636 creator A5043195275 @default.
- W3048345636 creator A5054123086 @default.
- W3048345636 creator A5087690322 @default.
- W3048345636 date "2020-08-12" @default.
- W3048345636 modified "2023-10-13" @default.
- W3048345636 title "NMR‐based clinical metabolomics revealed distinctive serum metabolic profiles in patients with spondyloarthritis" @default.
- W3048345636 cites W1498599153 @default.
- W3048345636 cites W1502374914 @default.
- W3048345636 cites W1655528082 @default.
- W3048345636 cites W1797422316 @default.
- W3048345636 cites W1854080461 @default.
- W3048345636 cites W1976327004 @default.
- W3048345636 cites W1982185581 @default.
- W3048345636 cites W1996113462 @default.
- W3048345636 cites W1997062226 @default.
- W3048345636 cites W2013607204 @default.
- W3048345636 cites W2015465447 @default.
- W3048345636 cites W2019607092 @default.
- W3048345636 cites W2022720370 @default.
- W3048345636 cites W2025701648 @default.
- W3048345636 cites W2036583236 @default.
- W3048345636 cites W2047733598 @default.
- W3048345636 cites W2051366884 @default.
- W3048345636 cites W2055270154 @default.
- W3048345636 cites W2063028213 @default.
- W3048345636 cites W2073503722 @default.
- W3048345636 cites W2082685967 @default.
- W3048345636 cites W2098714783 @default.
- W3048345636 cites W2099659190 @default.
- W3048345636 cites W2100463095 @default.
- W3048345636 cites W2105265356 @default.
- W3048345636 cites W2109172918 @default.
- W3048345636 cites W2109674683 @default.
- W3048345636 cites W2147263332 @default.
- W3048345636 cites W2153586956 @default.
- W3048345636 cites W2165568781 @default.
- W3048345636 cites W2187842472 @default.
- W3048345636 cites W2238610105 @default.
- W3048345636 cites W2292791349 @default.
- W3048345636 cites W2322044910 @default.
- W3048345636 cites W2409012378 @default.
- W3048345636 cites W2412531331 @default.
- W3048345636 cites W2520222164 @default.
- W3048345636 cites W2531766156 @default.
- W3048345636 cites W2534746645 @default.
- W3048345636 cites W2582679467 @default.
- W3048345636 cites W2738341831 @default.
- W3048345636 cites W2781559644 @default.
- W3048345636 cites W2805972698 @default.
- W3048345636 cites W2891663411 @default.
- W3048345636 cites W2914039268 @default.
- W3048345636 cites W3123549580 @default.
- W3048345636 cites W4210974969 @default.
- W3048345636 doi "https://doi.org/10.1002/mrc.5083" @default.
- W3048345636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32786028" @default.
- W3048345636 hasPublicationYear "2020" @default.
- W3048345636 type Work @default.
- W3048345636 sameAs 3048345636 @default.
- W3048345636 citedByCount "13" @default.
- W3048345636 countsByYear W30483456362021 @default.
- W3048345636 countsByYear W30483456362022 @default.
- W3048345636 countsByYear W30483456362023 @default.
- W3048345636 crossrefType "journal-article" @default.
- W3048345636 hasAuthorship W3048345636A5004147624 @default.
- W3048345636 hasAuthorship W3048345636A5037894792 @default.
- W3048345636 hasAuthorship W3048345636A5043195275 @default.
- W3048345636 hasAuthorship W3048345636A5054123086 @default.
- W3048345636 hasAuthorship W3048345636A5087690322 @default.
- W3048345636 hasConcept C126322002 @default.
- W3048345636 hasConcept C126838900 @default.
- W3048345636 hasConcept C134018914 @default.
- W3048345636 hasConcept C143409427 @default.
- W3048345636 hasConcept C185592680 @default.
- W3048345636 hasConcept C21565614 @default.
- W3048345636 hasConcept C2777477808 @default.
- W3048345636 hasConcept C2779134260 @default.
- W3048345636 hasConcept C2779896295 @default.
- W3048345636 hasConcept C2780306776 @default.
- W3048345636 hasConcept C2781123555 @default.
- W3048345636 hasConcept C2781197716 @default.
- W3048345636 hasConcept C43617362 @default.
- W3048345636 hasConcept C55493867 @default.
- W3048345636 hasConcept C71924100 @default.
- W3048345636 hasConcept C90924648 @default.
- W3048345636 hasConceptScore W3048345636C126322002 @default.
- W3048345636 hasConceptScore W3048345636C126838900 @default.
- W3048345636 hasConceptScore W3048345636C134018914 @default.
- W3048345636 hasConceptScore W3048345636C143409427 @default.
- W3048345636 hasConceptScore W3048345636C185592680 @default.
- W3048345636 hasConceptScore W3048345636C21565614 @default.
- W3048345636 hasConceptScore W3048345636C2777477808 @default.
- W3048345636 hasConceptScore W3048345636C2779134260 @default.
- W3048345636 hasConceptScore W3048345636C2779896295 @default.
- W3048345636 hasConceptScore W3048345636C2780306776 @default.