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- W3048356875 abstract "Mucosal ImmunologyMammals rely on secretory immunoglobulin A (SIgA) at the intestinal surface to maintain a homeostatic relationship with the commensal gut microbiota. B lymphocytes differentiate into IgA-producing plasma cells through a thymus-dependent pathway that depends on the B cell protein CD40 transducing a signal from CD40 ligand on T cells. Grasset et al. investigated the contribution of a receptor called TACI found predominantly on B cells to an alternative, thymus-independent pathway of plasma cell differentiation. The mucosal immune system was found to use parallel pathways dependent on either CD40 or TACI to provide B cells the help needed to generate SIgA capable of binding commensal bacteria.Sci. Immunol. 5 , eaat7117 (2020)." @default.
- W3048356875 created "2020-08-13" @default.
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- W3048356875 date "2020-08-06" @default.
- W3048356875 modified "2023-10-18" @default.
- W3048356875 title "The second way to anticommensal IgA" @default.
- W3048356875 doi "https://doi.org/10.1126/science.369.6504.639-t" @default.
- W3048356875 hasPublicationYear "2020" @default.
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