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- W3048367687 abstract "Despite remarkable progresses in nucleic acid-targeted tumor therapy, intracellular RNA and nuclear DNA-dual-targeted cancer treatments via a single nano-delivery system have been little investigated. Herein, cis-platinum pro-drugs (DSP) and cytotoxic protein ribonuclease A (RNase A) dual-therapeutic agents-loaded large-pore mesoporous silica-coated β-NaYF4:20%Yb,2%[email protected]β-NaGdF4 upconversion nanoplatforms (UCSPtR) were prepared for chemo-protein combination therapy. The obtained upconversion nanoplatforms can not only transport cytotoxic protein molecules and DSP into tumor cells to induce intracellular RNA degradation-mediated and nuclear DNA-targeted killings of cancer cells, but also achieve upconversion luminescence (UCL) and magnetic resonance (MR) dual-mode bioimaging. We believe this RNA and DNA-dual-targeted nanosystem will provide more enlightenments for tumor therapy." @default.
- W3048367687 created "2020-08-18" @default.
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- W3048367687 date "2021-02-01" @default.
- W3048367687 modified "2023-09-26" @default.
- W3048367687 title "Intracellular RNA and nuclear DNA-dual-targeted tumor therapy via upconversion nanoplatforms with UCL/MR dual-mode bioimaging" @default.
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- W3048367687 doi "https://doi.org/10.1016/j.cej.2020.126606" @default.
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