Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048371985> ?p ?o ?g. }
- W3048371985 endingPage "216" @default.
- W3048371985 startingPage "207" @default.
- W3048371985 abstract "The new pandemic Coronavirus Disease 2019 (COVID-19) causes a wide range of clinical consequences, from asymptomatic infection to acute respiratory failure, and it is very heterogeneous. The renin-angiotensin system (RAS) is well recognized as a key regulating system in circulatory homeostasis that plays prominent roles in pathophysiological processes in abnormal activation, for instance, renal and cardiovascular diseases, obesity, and stroke. Angiotensin-converting enzyme 2(ACE2) is a component of the RAS system. However, unlike the ACE, its activity is not inhibited by the ACE inhibitors. The major product of ACE2 is Ang1-7, known as a vasodilator peptide and part of the depressant arm of the RAS. There are two forms of ACE2; Transmembrane ACE2 and soluble ACE2. Coronavirus is covered with some proteins in order to help viral attachment to the cell membrane ACE2 as a receptor and then fuse and enter the cells. ACE2 was expressed in the oral cavity, salivary glands of the mouth, esophagus, myocardial cells, kidney, and enterocytes, along with all the respiratory tract, intestine, and blood vessels. In this article, the renin- angiotensin system and its components have been explained. Moreover, the organs involved in COVID-19 disease, and the possible causes of damage to these organs have also been discussed. The probable mechanism of using ACE2 in viral attachment and the probable treatment processes will also be reviewed based on the surface proteins of the virus and ACE2. In addition, we briefly discuss anti-angiotensin drugs and why patients with chronic diseases are more susceptible to COVID-19 infection and show worse progression." @default.
- W3048371985 created "2020-08-18" @default.
- W3048371985 creator A5030909658 @default.
- W3048371985 creator A5037472485 @default.
- W3048371985 creator A5041396595 @default.
- W3048371985 creator A5042713081 @default.
- W3048371985 creator A5044732562 @default.
- W3048371985 creator A5082553577 @default.
- W3048371985 date "2021-12-01" @default.
- W3048371985 modified "2023-09-24" @default.
- W3048371985 title "Angiotensin-Converting Enzyme 2 Roles in the Pathogenesis of COVID-19" @default.
- W3048371985 cites W1496869270 @default.
- W3048371985 cites W1567635264 @default.
- W3048371985 cites W1592232168 @default.
- W3048371985 cites W1965289779 @default.
- W3048371985 cites W1965570459 @default.
- W3048371985 cites W1966238900 @default.
- W3048371985 cites W1972642912 @default.
- W3048371985 cites W1974985368 @default.
- W3048371985 cites W1991854388 @default.
- W3048371985 cites W1994250435 @default.
- W3048371985 cites W2000040025 @default.
- W3048371985 cites W2004840558 @default.
- W3048371985 cites W2007361910 @default.
- W3048371985 cites W2010503769 @default.
- W3048371985 cites W2013422487 @default.
- W3048371985 cites W2016032331 @default.
- W3048371985 cites W2024416570 @default.
- W3048371985 cites W2038628089 @default.
- W3048371985 cites W2040181550 @default.
- W3048371985 cites W2040485426 @default.
- W3048371985 cites W2041718175 @default.
- W3048371985 cites W2044422062 @default.
- W3048371985 cites W2054960859 @default.
- W3048371985 cites W2079212189 @default.
- W3048371985 cites W2086677194 @default.
- W3048371985 cites W2090418625 @default.
- W3048371985 cites W2094254801 @default.
- W3048371985 cites W2098873157 @default.
- W3048371985 cites W2101176145 @default.
- W3048371985 cites W2111584700 @default.
- W3048371985 cites W2112148801 @default.
- W3048371985 cites W2114420102 @default.
- W3048371985 cites W2122061350 @default.
- W3048371985 cites W2125924413 @default.
- W3048371985 cites W2126651811 @default.
- W3048371985 cites W2127087522 @default.
- W3048371985 cites W2128356968 @default.
- W3048371985 cites W2129053556 @default.
- W3048371985 cites W2133466283 @default.
- W3048371985 cites W2135832604 @default.
- W3048371985 cites W2139147784 @default.
- W3048371985 cites W2146476111 @default.
- W3048371985 cites W2149146712 @default.
- W3048371985 cites W2155118902 @default.
- W3048371985 cites W2156950978 @default.
- W3048371985 cites W2161150359 @default.
- W3048371985 cites W2161399617 @default.
- W3048371985 cites W2161477365 @default.
- W3048371985 cites W2163378092 @default.
- W3048371985 cites W2169328873 @default.
- W3048371985 cites W2178842413 @default.
- W3048371985 cites W2183498078 @default.
- W3048371985 cites W2300696486 @default.
- W3048371985 cites W2558640301 @default.
- W3048371985 cites W2625441704 @default.
- W3048371985 cites W2727871577 @default.
- W3048371985 cites W2780715796 @default.
- W3048371985 cites W2900167300 @default.
- W3048371985 cites W2944213565 @default.
- W3048371985 cites W2965816238 @default.
- W3048371985 cites W2977677493 @default.
- W3048371985 cites W2986891858 @default.
- W3048371985 cites W2995811496 @default.
- W3048371985 cites W3000834295 @default.
- W3048371985 cites W3002108456 @default.
- W3048371985 cites W3004071935 @default.
- W3048371985 cites W3005943294 @default.
- W3048371985 cites W3007682019 @default.
- W3048371985 cites W3007940623 @default.
- W3048371985 cites W3008047170 @default.
- W3048371985 cites W3008295344 @default.
- W3048371985 cites W3008928028 @default.
- W3048371985 cites W3008962515 @default.
- W3048371985 cites W3008997778 @default.
- W3048371985 cites W3009351593 @default.
- W3048371985 cites W3009912996 @default.
- W3048371985 cites W3010020071 @default.
- W3048371985 cites W3010350910 @default.
- W3048371985 cites W3010603845 @default.
- W3048371985 cites W3011147220 @default.
- W3048371985 cites W3011176674 @default.
- W3048371985 cites W3011995143 @default.
- W3048371985 cites W3012339747 @default.
- W3048371985 cites W3012725239 @default.
- W3048371985 cites W3012905869 @default.
- W3048371985 cites W3013152614 @default.
- W3048371985 cites W3013449264 @default.