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• W3048375460 endingPage "2422" @default.
• W3048375460 startingPage "2422" @default.
• W3048375460 abstract "Aging and osteoarthritis (OA) are associated with a high risk of muscle mass loss, which can lead to physical disability. This study investigated the effectiveness of protein supplementation combined with exercise training (PS + ET) in improving muscle mass and functional outcomes in older adults with lower-limb OA. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) on the effectiveness of PS + ET in older adults with hip or knee OA. Meta-analysis and risk of bias assessment of the included RCTs were conducted. Six RCTs were included in this systemic review; they had a median (range/total) Physiotherapy Evidence Database (PEDro) score of 7 (6–9) out of 10, respectively. Five RCTs that enrolled patients who underwent total joint replacement were included in this meta-analysis. The PS + ET group exhibited significant improvements in muscle mass (standard mean difference [SMD] = 1.13, p < 0.00001), pain (SMD = 1.36, p < 0.00001), and muscle strength (SMD = 0.44, p = 0.04). Our findings suggest that PS + ET improves muscle mass, muscle strength, and functional outcomes and reduces pain in older adults with lower-limb OA, particularly in those who have undergone total joint replacement." @default.
• W3048375460 created "2020-08-18" @default.
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• W3048375460 date "2020-08-12" @default.
• W3048375460 modified "2023-10-18" @default.
• W3048375460 title "Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials" @default.
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• W3048375460 doi "https://doi.org/10.3390/nu12082422" @default.
• W3048375460 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7468926" @default.
• W3048375460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32806718" @default.
• W3048375460 hasPublicationYear "2020" @default.
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