Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048378744> ?p ?o ?g. }
- W3048378744 abstract "Abstract Psoriatic arthritis (PsA) is a chronic musculoskeletal inflammatory disease found in up to 30% of psoriasis patients. Prolargin—an extracellular matrix (ECM) protein present in cartilage and tendon—has been previously shown elevated in serum of patients with psoriasis. ECM protein fragments can reflect tissue turnover and pathological changes; thus, this study aimed to develop, validate and characterize a novel biomarker PROM targeting a matrix metalloproteinase (MMP)-cleaved prolargin neo-epitope, and to evaluate it as a biomarker for PsA. A competitive ELISA was developed with a monoclonal mouse antibody; dilution- and spiking-recovery, inter- and intra-variation, and accuracy were evaluated. Serum levels were evaluated in 55 healthy individuals and 111 patients diagnosed with PsA by the CASPAR criteria. Results indicated that the PROM assay was specific for the neo-epitope. Inter- and intra- assay variations were 11% and 4%, respectively. PROM was elevated (p = 0.0003) in patients with PsA (median: 0.24, IQR: 0.19–0.31) compared to healthy controls (0.18; 0.14–0.23) at baseline. AUROC for separation of healthy controls from PsA patients was 0.674 (95% CI 0.597–0.744, P < 0.001). In conclusion, MMP-cleaved prolargin can be quantified in serum by the PROM assay and has the potential to separate patients with PsA from healthy controls." @default.
- W3048378744 created "2020-08-18" @default.
- W3048378744 creator A5001283544 @default.
- W3048378744 creator A5006255197 @default.
- W3048378744 creator A5006671849 @default.
- W3048378744 creator A5022941584 @default.
- W3048378744 creator A5025108583 @default.
- W3048378744 creator A5025401110 @default.
- W3048378744 creator A5054710115 @default.
- W3048378744 creator A5083004835 @default.
- W3048378744 creator A5087875931 @default.
- W3048378744 date "2020-08-11" @default.
- W3048378744 modified "2023-09-27" @default.
- W3048378744 title "A novel biomarker of MMP-cleaved prolargin is elevated in patients with psoriatic arthritis" @default.
- W3048378744 cites W1483788981 @default.
- W3048378744 cites W1519059617 @default.
- W3048378744 cites W1552422862 @default.
- W3048378744 cites W1683598410 @default.
- W3048378744 cites W1968405676 @default.
- W3048378744 cites W1974719543 @default.
- W3048378744 cites W1986676191 @default.
- W3048378744 cites W2002781399 @default.
- W3048378744 cites W2002830364 @default.
- W3048378744 cites W2008710073 @default.
- W3048378744 cites W2016942373 @default.
- W3048378744 cites W2035050000 @default.
- W3048378744 cites W2049453047 @default.
- W3048378744 cites W2054228700 @default.
- W3048378744 cites W2054482368 @default.
- W3048378744 cites W2059254204 @default.
- W3048378744 cites W2082340092 @default.
- W3048378744 cites W2083180635 @default.
- W3048378744 cites W2083707884 @default.
- W3048378744 cites W2130111449 @default.
- W3048378744 cites W2137833678 @default.
- W3048378744 cites W2140760073 @default.
- W3048378744 cites W2143233950 @default.
- W3048378744 cites W2172367231 @default.
- W3048378744 cites W2285868925 @default.
- W3048378744 cites W2304284663 @default.
- W3048378744 cites W2323640134 @default.
- W3048378744 cites W2439636377 @default.
- W3048378744 cites W2554379118 @default.
- W3048378744 cites W2585071281 @default.
- W3048378744 cites W2595512591 @default.
- W3048378744 cites W2799950849 @default.
- W3048378744 cites W2892275967 @default.
- W3048378744 cites W3014805148 @default.
- W3048378744 cites W4241915332 @default.
- W3048378744 cites W4251566187 @default.
- W3048378744 cites W2995459318 @default.
- W3048378744 doi "https://doi.org/10.1038/s41598-020-70327-0" @default.
- W3048378744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7419545" @default.
- W3048378744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32782251" @default.
- W3048378744 hasPublicationYear "2020" @default.
- W3048378744 type Work @default.
- W3048378744 sameAs 3048378744 @default.
- W3048378744 citedByCount "11" @default.
- W3048378744 countsByYear W30483787442021 @default.
- W3048378744 countsByYear W30483787442022 @default.
- W3048378744 countsByYear W30483787442023 @default.
- W3048378744 crossrefType "journal-article" @default.
- W3048378744 hasAuthorship W3048378744A5001283544 @default.
- W3048378744 hasAuthorship W3048378744A5006255197 @default.
- W3048378744 hasAuthorship W3048378744A5006671849 @default.
- W3048378744 hasAuthorship W3048378744A5022941584 @default.
- W3048378744 hasAuthorship W3048378744A5025108583 @default.
- W3048378744 hasAuthorship W3048378744A5025401110 @default.
- W3048378744 hasAuthorship W3048378744A5054710115 @default.
- W3048378744 hasAuthorship W3048378744A5083004835 @default.
- W3048378744 hasAuthorship W3048378744A5087875931 @default.
- W3048378744 hasBestOaLocation W30483787441 @default.
- W3048378744 hasConcept C105702510 @default.
- W3048378744 hasConcept C109523444 @default.
- W3048378744 hasConcept C126322002 @default.
- W3048378744 hasConcept C131872663 @default.
- W3048378744 hasConcept C142724271 @default.
- W3048378744 hasConcept C143998085 @default.
- W3048378744 hasConcept C159654299 @default.
- W3048378744 hasConcept C195616568 @default.
- W3048378744 hasConcept C203014093 @default.
- W3048378744 hasConcept C204787440 @default.
- W3048378744 hasConcept C2776164576 @default.
- W3048378744 hasConcept C2776260265 @default.
- W3048378744 hasConcept C2777077863 @default.
- W3048378744 hasConcept C2777364248 @default.
- W3048378744 hasConcept C2778232976 @default.
- W3048378744 hasConcept C2780550940 @default.
- W3048378744 hasConcept C2780564577 @default.
- W3048378744 hasConcept C2781197716 @default.
- W3048378744 hasConcept C542903549 @default.
- W3048378744 hasConcept C55493867 @default.
- W3048378744 hasConcept C71924100 @default.
- W3048378744 hasConcept C86803240 @default.
- W3048378744 hasConcept C90924648 @default.
- W3048378744 hasConceptScore W3048378744C105702510 @default.
- W3048378744 hasConceptScore W3048378744C109523444 @default.
- W3048378744 hasConceptScore W3048378744C126322002 @default.
- W3048378744 hasConceptScore W3048378744C131872663 @default.
- W3048378744 hasConceptScore W3048378744C142724271 @default.