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- W3048379612 abstract "Purpose of review To explore the potential of a low carbohydrate ketogenic diet (LCKD) to counter physical activity intolerance, pain and muscle damage for glycogen storage disease (GSD) V and VII, and highlight the realistic possibility that nutrition could be key. Recent findings Carbohydrate (CHO) ingestion during physical activity in GSDV and a LCKD for GSDVII is common. For the latter, a long-term study demonstrated improvement in physiological markers while on a LCKD. This included improvement in aerobic power and activity tolerance. In GSDV, preliminary research on a LCKD suggest a diet of 75% fat, 15% protein, 10% CHO, is best for improved function and compliance. Ketones provide immediate fuel for acute physical activity, and have an epigenetic role, improving ketone and lipid use. Evidence from elite athletes found a LCKD can increase fat oxidation and is optimal at 70% VO2max. This suggests the need to also improve conditioning via exercise to maximize the benefit of a LCKD. Summary A high CHO diet in GSDV and VII comes with a restricted physical activity capacity alongside significant pain, muscle damage and risk of renal failure. Mounting evidence suggests a LCKD is efficacious for both disorders providing an immediate fuel source which may negate the need for a ‘warm-up’ prior to every activity and restore ‘normal’ function." @default.
- W3048379612 created "2020-08-18" @default.
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- W3048379612 date "2020-08-06" @default.
- W3048379612 modified "2023-09-27" @default.
- W3048379612 title "The potential of a ketogenic diet to minimize effects of the metabolic fault in glycogen storage disease V and VII" @default.
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- W3048379612 doi "https://doi.org/10.1097/med.0000000000000567" @default.
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