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- W3048392290 abstract "Significance Missing bases or abasic sites in the DNA were discovered in the 1960s and spawned the field of DNA repair and advanced our understanding of cancer and aging. In contrast, abasic sites in the RNA are not known except for the site in ribosomal RNA induced by the plant poison ricin. Here, we uncover RNA abasic sites in yeast and human cells, which are not as rare as assumed; there are about three abasic sites per million ribonucleotides. We identify a glycosylase that generates RNA abasic sites and an AP endonuclease that processes these sites. Additionally, we showed that RNA abasic sites are coupled to a regulatory nucleic acid structure, known as an R-loop, suggesting their role in RNA processing." @default.
- W3048392290 created "2020-08-18" @default.
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- W3048392290 date "2020-08-11" @default.
- W3048392290 modified "2023-10-15" @default.
- W3048392290 title "RNA abasic sites in yeast and human cells" @default.
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- W3048392290 doi "https://doi.org/10.1073/pnas.2011511117" @default.
- W3048392290 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7456069" @default.
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