FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048392561> ?p ?o ?g. }

• W3048392561 endingPage "141685" @default.
• W3048392561 startingPage "141685" @default.
• W3048392561 abstract "Human exposure to bisphenol A (BPA) is unavoidable in daily life. Recently, research has showen that BPA could induce oxidative imbalance, thereby causing reproductive toxicity and liver dysfunction. Accumulated evidence has demonstrated that metformin possesses strong anti-oxidative properties. This study aimed to study the mechanism underlying the hepatic-protective effect of metformin on liver injury induced by BPA in rats via the UPLC-MS/MS metabolomics approach. Forty-two male rats were randomly divided into six groups (n = 7), namely the saline group (control), the corn oil group (vehicle), the metformin group (Met), the bisphenol A group (BPA), the bisphenol A and metformin group (BPA + Met), and the bisphenol A and diammonium glycyrrhizinate (positive control) group (BPA + DG). Serum was collected for biochemical analysis and metabolomics, and liver tissue was collected for histopathology and metabolomics in each group. We found that metformin could significantly reduce the levels of liver function enzymes (ALT, AST and GGT) and ameliorate inflammatory cell infiltration and hepatocyte necrosis induced by BPA. On the other hand, metformin could significantly enhance the total antioxidant capacity in BPA rats. Notably, metabolomics data indicated that the principal altered metabolic pathways based on the 26 differential metabolites in liver tissue, and 21 in serum among vehicle, BPA and BPA + Met groups, respectively, including cysteine and methionine metabolism, glutathione metabolism, and arginine biosynthesis and purine metabolism. Additionally, metformin significantly increased cystathionine β synthase (CBS) and cystathionine γ lyase (CSE), thus reducing serum levels of homocysteine and increasing hepatic levels of cysteine and glutathione in BPA-treated rats. Overall, this study's results provided new insights into the role and mechanism of metformin in BPA-induced liver injury in rats." @default.
• W3048392561 created "2020-08-18" @default.
• W3048392561 creator A5003819930 @default.
• W3048392561 creator A5020832042 @default.
• W3048392561 creator A5042389757 @default.
• W3048392561 creator A5045890093 @default.
• W3048392561 creator A5060015077 @default.
• W3048392561 creator A5069139562 @default.
• W3048392561 creator A5078376015 @default.
• W3048392561 creator A5082366947 @default.
• W3048392561 creator A5090051459 @default.
• W3048392561 date "2021-01-01" @default.
• W3048392561 modified "2023-10-18" @default.
• W3048392561 title "Protective effect of metformin on BPA-induced liver toxicity in rats through upregulation of cystathionine β synthase and cystathionine γ lyase expression" @default.
• W3048392561 cites W1958756232 @default.
• W3048392561 cites W2007727470 @default.
• W3048392561 cites W2083132306 @default.
• W3048392561 cites W2126434738 @default.
• W3048392561 cites W2509500740 @default.
• W3048392561 cites W2530872875 @default.
• W3048392561 cites W2560783852 @default.
• W3048392561 cites W2732528809 @default.
• W3048392561 cites W2765429845 @default.
• W3048392561 cites W2767998374 @default.
• W3048392561 cites W2796307715 @default.
• W3048392561 cites W2883449173 @default.
• W3048392561 cites W2884724691 @default.
• W3048392561 cites W2888526418 @default.
• W3048392561 cites W2892994507 @default.
• W3048392561 cites W2898219654 @default.
• W3048392561 cites W2902969217 @default.
• W3048392561 cites W2911127775 @default.
• W3048392561 cites W2911391985 @default.
• W3048392561 cites W2945012235 @default.
• W3048392561 cites W2949778565 @default.
• W3048392561 cites W2971400112 @default.
• W3048392561 cites W2972083076 @default.
• W3048392561 cites W2977255533 @default.
• W3048392561 cites W2979455989 @default.
• W3048392561 cites W2987795180 @default.
• W3048392561 cites W2988374337 @default.
• W3048392561 cites W2916049165 @default.
• W3048392561 doi "https://doi.org/10.1016/j.scitotenv.2020.141685" @default.
• W3048392561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32862004" @default.
• W3048392561 hasPublicationYear "2021" @default.
• W3048392561 type Work @default.
• W3048392561 sameAs 3048392561 @default.
• W3048392561 citedByCount "23" @default.
• W3048392561 countsByYear W30483925612021 @default.
• W3048392561 countsByYear W30483925612022 @default.
• W3048392561 countsByYear W30483925612023 @default.
• W3048392561 crossrefType "journal-article" @default.
• W3048392561 hasAuthorship W3048392561A5003819930 @default.
• W3048392561 hasAuthorship W3048392561A5020832042 @default.
• W3048392561 hasAuthorship W3048392561A5042389757 @default.
• W3048392561 hasAuthorship W3048392561A5045890093 @default.
• W3048392561 hasAuthorship W3048392561A5060015077 @default.
• W3048392561 hasAuthorship W3048392561A5069139562 @default.
• W3048392561 hasAuthorship W3048392561A5078376015 @default.
• W3048392561 hasAuthorship W3048392561A5082366947 @default.
• W3048392561 hasAuthorship W3048392561A5090051459 @default.
• W3048392561 hasConcept C126322002 @default.
• W3048392561 hasConcept C134018914 @default.
• W3048392561 hasConcept C16525657 @default.
• W3048392561 hasConcept C181199279 @default.
• W3048392561 hasConcept C185592680 @default.
• W3048392561 hasConcept C2780323712 @default.
• W3048392561 hasConcept C2780912031 @default.
• W3048392561 hasConcept C515207424 @default.
• W3048392561 hasConcept C538909803 @default.
• W3048392561 hasConcept C55493867 @default.
• W3048392561 hasConcept C555293320 @default.
• W3048392561 hasConcept C71924100 @default.
• W3048392561 hasConcept C86803240 @default.
• W3048392561 hasConcept C98274493 @default.
• W3048392561 hasConceptScore W3048392561C126322002 @default.
• W3048392561 hasConceptScore W3048392561C134018914 @default.
• W3048392561 hasConceptScore W3048392561C16525657 @default.
• W3048392561 hasConceptScore W3048392561C181199279 @default.
• W3048392561 hasConceptScore W3048392561C185592680 @default.
• W3048392561 hasConceptScore W3048392561C2780323712 @default.
• W3048392561 hasConceptScore W3048392561C2780912031 @default.
• W3048392561 hasConceptScore W3048392561C515207424 @default.
• W3048392561 hasConceptScore W3048392561C538909803 @default.
• W3048392561 hasConceptScore W3048392561C55493867 @default.
• W3048392561 hasConceptScore W3048392561C555293320 @default.
• W3048392561 hasConceptScore W3048392561C71924100 @default.
• W3048392561 hasConceptScore W3048392561C86803240 @default.
• W3048392561 hasConceptScore W3048392561C98274493 @default.
• W3048392561 hasFunder F4320321001 @default.
• W3048392561 hasFunder F4320321543 @default.
• W3048392561 hasLocation W30483925611 @default.
• W3048392561 hasLocation W30483925612 @default.
• W3048392561 hasOpenAccess W3048392561 @default.
• W3048392561 hasPrimaryLocation W30483925611 @default.
• W3048392561 hasRelatedWork W1977223774 @default.
• W3048392561 hasRelatedWork W2005084305 @default.
• W3048392561 hasRelatedWork W2016264464 @default.

• next