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- W3048393463 abstract "Abstract Live‐cell imaging with fluorescent probes is an essential tool in chemical biology to visualize the dynamics of biological processes in real‐time. Intracellular disease biomarker imaging remains a formidable challenge due to the intrinsic limitations of conventional fluorescent probes and the complex nature of cells. This work reports the in cellulo assembly of a fluorescent probe to image cyclooxygenase‐2 (COX‐2). We developed celecoxib‐azide derivative 14 , possessing favorable biophysical properties and excellent COX‐2 selectivity profile. In cellulo strain‐promoted fluorogenic click chemistry of COX‐2‐engaged compound 14 with non/weakly‐fluorescent compounds 11 and 17 formed fluorescent probes 15 and 18 for the detection of COX‐2 in living cells. Competitive binding studies, biophysical, and comprehensive computational analyses were used to describe protein‐ligand interactions. The reported new chemical toolbox enables precise visualization and tracking of COX‐2 in live cells with superior sensitivity in the visible range." @default.
- W3048393463 created "2020-08-18" @default.
- W3048393463 creator A5018891381 @default.
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- W3048393463 date "2020-12-07" @default.
- W3048393463 modified "2023-09-26" @default.
- W3048393463 title "In Cellulo Generation of Fluorescent Probes for Live‐Cell Imaging of Cylooxygenase‐2" @default.
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- W3048393463 doi "https://doi.org/10.1002/chem.202003315" @default.
- W3048393463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32786126" @default.
- W3048393463 hasPublicationYear "2020" @default.
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