FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048393766> ?p ?o ?g. }

• W3048393766 endingPage "991" @default.
• W3048393766 startingPage "991" @default.
• W3048393766 abstract "Ankylosing spondylitis (AS) is a common form of inflammatory arthritis. Micheliolide (MCL), a sesquiterpene lactone, is reportedly involved in the alleviation of inflammatory response. This study aimed to investigate the mechanism of MCL in the treatment of AS.Mice were randomly divided into five groups: the sham group, the MCL (50 mg/kg) group, the AS model group, the AS + MCL (20 mg/kg) group, and the AS + MCL (50 mg/kg) group. After the addition of the inhibitor celastrol, mice were randomly divided into five groups: the sham group, the AS model group, the AS + MCL (50 mg/kg) group, the AS + Celastrol (1 mg/kg) group, and the AS + Celastrol (1 mg/kg) + MCL (50 mg/kg) group.Compared with the AS model mice, the protein expression levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, and IL-18 were decreased after MCL treatment. The protein expression levels of capase-1 p10, IL-1β p17, NOD-like receptor family and pyrin domain containing 3 (NLRP3), caspase-1, and apoptosis-associated speck-like protein (ASC) were also reduced. The protein expression levels of Interferon (IFN)-γ were down-regulated, but levels of IL-4 were increased. Western blotting and immunohistochemistry revealed that the levels of p-IκB α were up-regulated, while the levels of phosphorylated-p65 were down-regulated. After the addition of celastrol, MCL treatment significantly reduced the levels of p-p65, NLRP3, caspase-1, and ASC. Meanwhile, the levels of IFN-γ were markedly down-regulated, but the levels of IL-4 were enhanced.Our study found that MCL suppressed the activation of NLRP3 inflammasome and maintained the balance of Th1/Th2 via regulating NF-κB signaling. Therefore, MCL could potentially be used to treat AS." @default.
• W3048393766 created "2020-08-18" @default.
• W3048393766 creator A5010479652 @default.
• W3048393766 creator A5056521451 @default.
• W3048393766 creator A5065380005 @default.
• W3048393766 date "2020-08-01" @default.
• W3048393766 modified "2023-09-25" @default.
• W3048393766 title "Micheliolide alleviates ankylosing spondylitis (AS) by suppressing the activation of the NLRP3 inflammasome and maintaining the balance of Th1/Th2 via regulating the NF-κB signaling pathway" @default.
• W3048393766 cites W1594203091 @default.
• W3048393766 cites W189264004 @default.
• W3048393766 cites W1969833817 @default.
• W3048393766 cites W1976391393 @default.
• W3048393766 cites W1990725163 @default.
• W3048393766 cites W2013761531 @default.
• W3048393766 cites W2021168296 @default.
• W3048393766 cites W2037544412 @default.
• W3048393766 cites W2053936064 @default.
• W3048393766 cites W2057665484 @default.
• W3048393766 cites W2074660641 @default.
• W3048393766 cites W2143263732 @default.
• W3048393766 cites W2143498069 @default.
• W3048393766 cites W2176674050 @default.
• W3048393766 cites W2207177436 @default.
• W3048393766 cites W2218778538 @default.
• W3048393766 cites W2269541623 @default.
• W3048393766 cites W2283785111 @default.
• W3048393766 cites W2295125658 @default.
• W3048393766 cites W2300538748 @default.
• W3048393766 cites W2331913905 @default.
• W3048393766 cites W2403101766 @default.
• W3048393766 cites W2516142875 @default.
• W3048393766 cites W2580114732 @default.
• W3048393766 cites W2586569178 @default.
• W3048393766 cites W2598587416 @default.
• W3048393766 cites W2619695335 @default.
• W3048393766 cites W2621789138 @default.
• W3048393766 cites W2748447177 @default.
• W3048393766 cites W2766265161 @default.
• W3048393766 cites W2776012108 @default.
• W3048393766 cites W2785091318 @default.
• W3048393766 cites W2796472777 @default.
• W3048393766 cites W2888676321 @default.
• W3048393766 cites W2889737720 @default.
• W3048393766 cites W2921970308 @default.
• W3048393766 cites W2974844263 @default.
• W3048393766 cites W2980174261 @default.
• W3048393766 doi "https://doi.org/10.21037/atm-20-4987" @default.
• W3048393766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7475468" @default.
• W3048393766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32953791" @default.
• W3048393766 hasPublicationYear "2020" @default.
• W3048393766 type Work @default.
• W3048393766 sameAs 3048393766 @default.
• W3048393766 citedByCount "11" @default.
• W3048393766 countsByYear W30483937662021 @default.
• W3048393766 countsByYear W30483937662022 @default.
• W3048393766 countsByYear W30483937662023 @default.
• W3048393766 crossrefType "journal-article" @default.
• W3048393766 hasAuthorship W3048393766A5010479652 @default.
• W3048393766 hasAuthorship W3048393766A5056521451 @default.
• W3048393766 hasAuthorship W3048393766A5065380005 @default.
• W3048393766 hasBestOaLocation W30483937661 @default.
• W3048393766 hasConcept C126322002 @default.
• W3048393766 hasConcept C139174496 @default.
• W3048393766 hasConcept C170493617 @default.
• W3048393766 hasConcept C17991360 @default.
• W3048393766 hasConcept C185592680 @default.
• W3048393766 hasConcept C190283241 @default.
• W3048393766 hasConcept C203014093 @default.
• W3048393766 hasConcept C2776914184 @default.
• W3048393766 hasConcept C2777209026 @default.
• W3048393766 hasConcept C2777228702 @default.
• W3048393766 hasConcept C2777402515 @default.
• W3048393766 hasConcept C2777730290 @default.
• W3048393766 hasConcept C2779730028 @default.
• W3048393766 hasConcept C55493867 @default.
• W3048393766 hasConcept C71924100 @default.
• W3048393766 hasConcept C98274493 @default.
• W3048393766 hasConceptScore W3048393766C126322002 @default.
• W3048393766 hasConceptScore W3048393766C139174496 @default.
• W3048393766 hasConceptScore W3048393766C170493617 @default.
• W3048393766 hasConceptScore W3048393766C17991360 @default.
• W3048393766 hasConceptScore W3048393766C185592680 @default.
• W3048393766 hasConceptScore W3048393766C190283241 @default.
• W3048393766 hasConceptScore W3048393766C203014093 @default.
• W3048393766 hasConceptScore W3048393766C2776914184 @default.
• W3048393766 hasConceptScore W3048393766C2777209026 @default.
• W3048393766 hasConceptScore W3048393766C2777228702 @default.
• W3048393766 hasConceptScore W3048393766C2777402515 @default.
• W3048393766 hasConceptScore W3048393766C2777730290 @default.
• W3048393766 hasConceptScore W3048393766C2779730028 @default.
• W3048393766 hasConceptScore W3048393766C55493867 @default.
• W3048393766 hasConceptScore W3048393766C71924100 @default.
• W3048393766 hasConceptScore W3048393766C98274493 @default.
• W3048393766 hasIssue "16" @default.
• W3048393766 hasLocation W30483937661 @default.
• W3048393766 hasLocation W30483937662 @default.
• W3048393766 hasLocation W30483937663 @default.
• W3048393766 hasOpenAccess W3048393766 @default.

• next