Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048397169> ?p ?o ?g. }
- W3048397169 endingPage "844" @default.
- W3048397169 startingPage "832" @default.
- W3048397169 abstract "Leishmania are parasitic protists that cause a spectrum of diseases in humans characterized by the formation of granulomatous lesions in the skin or other tissues, such as liver and spleen. The extent to which Leishmania granulomas constrain or promote parasite growth is critically dependent on the host T-helper type 1/T-helper type 2 immune response and the localized functional polarization of infected and noninfected macrophages toward a classically (M1) or alternatively (M2) activated phenotype. Recent studies have shown that metabolic reprograming of M1 and M2 macrophages underpins the capacity of these cells to act as permissive or nonpermissive host reservoirs, respectively. In this review, we highlight the metabolic requirements of Leishmania amastigotes and the evidence that these parasites induce and/or exploit metabolic reprogramming of macrophage metabolism. We also focus on recent studies highlighting the role of key macrophage metabolic signaling pathways, such as mechanistic target of rapamycin, adenosine monophosphate-activated protein kinase and peroxisome proliferator receptor gamma in regulating the pathological progression of Leishmania granulomas. These studies highlight the intimate connectivity between Leishmania and host cell metabolism, the need to investigate these interactions in vivo and the potential to exploit host cell metabolic signaling pathways in developing new host-directed therapies." @default.
- W3048397169 created "2020-08-18" @default.
- W3048397169 creator A5049064733 @default.
- W3048397169 creator A5049449889 @default.
- W3048397169 date "2020-09-08" @default.
- W3048397169 modified "2023-10-16" @default.
- W3048397169 title "Immunometabolism of<i>Leishmania</i>granulomas" @default.
- W3048397169 cites W1490035833 @default.
- W3048397169 cites W1765010108 @default.
- W3048397169 cites W1787918626 @default.
- W3048397169 cites W1804602290 @default.
- W3048397169 cites W1966916118 @default.
- W3048397169 cites W1992149604 @default.
- W3048397169 cites W1994802782 @default.
- W3048397169 cites W2012372447 @default.
- W3048397169 cites W2017699535 @default.
- W3048397169 cites W2035430351 @default.
- W3048397169 cites W2035987993 @default.
- W3048397169 cites W2038425317 @default.
- W3048397169 cites W2047936269 @default.
- W3048397169 cites W2052729921 @default.
- W3048397169 cites W2055375742 @default.
- W3048397169 cites W2061166947 @default.
- W3048397169 cites W2063862054 @default.
- W3048397169 cites W2083287741 @default.
- W3048397169 cites W2098344777 @default.
- W3048397169 cites W2104901632 @default.
- W3048397169 cites W2107915297 @default.
- W3048397169 cites W2108173186 @default.
- W3048397169 cites W2123108267 @default.
- W3048397169 cites W2123659126 @default.
- W3048397169 cites W2124405613 @default.
- W3048397169 cites W2127984506 @default.
- W3048397169 cites W2130509160 @default.
- W3048397169 cites W2137161714 @default.
- W3048397169 cites W2140380746 @default.
- W3048397169 cites W2141743919 @default.
- W3048397169 cites W2157939920 @default.
- W3048397169 cites W2167485774 @default.
- W3048397169 cites W2189852070 @default.
- W3048397169 cites W2195662214 @default.
- W3048397169 cites W2210729715 @default.
- W3048397169 cites W2215373933 @default.
- W3048397169 cites W2287265171 @default.
- W3048397169 cites W2288165580 @default.
- W3048397169 cites W2337900869 @default.
- W3048397169 cites W2340702357 @default.
- W3048397169 cites W2400548996 @default.
- W3048397169 cites W2415237006 @default.
- W3048397169 cites W2523479023 @default.
- W3048397169 cites W2530726117 @default.
- W3048397169 cites W2533921510 @default.
- W3048397169 cites W2573267280 @default.
- W3048397169 cites W2573501158 @default.
- W3048397169 cites W2606679493 @default.
- W3048397169 cites W2614920987 @default.
- W3048397169 cites W2685131096 @default.
- W3048397169 cites W2733319564 @default.
- W3048397169 cites W2738870889 @default.
- W3048397169 cites W2743940108 @default.
- W3048397169 cites W2760815328 @default.
- W3048397169 cites W2766243612 @default.
- W3048397169 cites W2771142813 @default.
- W3048397169 cites W2781438577 @default.
- W3048397169 cites W2795832109 @default.
- W3048397169 cites W2800636563 @default.
- W3048397169 cites W2809111387 @default.
- W3048397169 cites W2817354824 @default.
- W3048397169 cites W2883262560 @default.
- W3048397169 cites W2888747848 @default.
- W3048397169 cites W2891646530 @default.
- W3048397169 cites W2892636927 @default.
- W3048397169 cites W2910344496 @default.
- W3048397169 cites W2911000420 @default.
- W3048397169 cites W2913930991 @default.
- W3048397169 cites W2918870426 @default.
- W3048397169 cites W2923646916 @default.
- W3048397169 cites W2971804666 @default.
- W3048397169 cites W2977925763 @default.
- W3048397169 cites W2978404162 @default.
- W3048397169 cites W2997073647 @default.
- W3048397169 cites W3003746613 @default.
- W3048397169 cites W3005150131 @default.
- W3048397169 cites W3007196650 @default.
- W3048397169 cites W3010318716 @default.
- W3048397169 cites W3010443092 @default.
- W3048397169 cites W3013534036 @default.
- W3048397169 cites W3015425237 @default.
- W3048397169 cites W3016668977 @default.
- W3048397169 cites W4211073781 @default.
- W3048397169 doi "https://doi.org/10.1111/imcb.12394" @default.
- W3048397169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32780446" @default.
- W3048397169 hasPublicationYear "2020" @default.
- W3048397169 type Work @default.
- W3048397169 sameAs 3048397169 @default.
- W3048397169 citedByCount "30" @default.
- W3048397169 countsByYear W30483971692020 @default.
- W3048397169 countsByYear W30483971692021 @default.