Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048397235> ?p ?o ?g. }
- W3048397235 abstract "Short/dysfunctional telomeres are at the origin of idiopathic pulmonary fibrosis (IPF) in patients mutant for telomere maintenance genes. However, it remains unknown whether physiological aging leads to short telomeres in the lung, thus leading to IPF with aging. Here, we find that physiological aging in wild-type mice leads to telomere shortening and a reduced proliferative potential of alveolar type II cells and club cells, increased cellular senescence and DNA damage, increased fibroblast activation and collagen deposits, and impaired lung biophysics, suggestive of a fibrosis-like pathology. Treatment of both wild-type and telomerase-deficient mice with telomerase gene therapy prevented the onset of lung profibrotic pathologies. These findings suggest that short telomeres associated with physiological aging are at the origin of IPF and that a potential treatment for IPF based on telomerase activation would be of interest not only for patients with telomerase mutations but also for sporadic cases of IPF associated with physiological aging." @default.
- W3048397235 created "2020-08-18" @default.
- W3048397235 creator A5023088425 @default.
- W3048397235 creator A5046250168 @default.
- W3048397235 creator A5070199101 @default.
- W3048397235 creator A5075866459 @default.
- W3048397235 creator A5085741167 @default.
- W3048397235 creator A5085977927 @default.
- W3048397235 date "2020-08-10" @default.
- W3048397235 modified "2023-10-18" @default.
- W3048397235 title "Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging" @default.
- W3048397235 cites W1497143641 @default.
- W3048397235 cites W1653749976 @default.
- W3048397235 cites W1928219810 @default.
- W3048397235 cites W1970891016 @default.
- W3048397235 cites W1972655555 @default.
- W3048397235 cites W1973912766 @default.
- W3048397235 cites W1978893674 @default.
- W3048397235 cites W1981775109 @default.
- W3048397235 cites W1984552013 @default.
- W3048397235 cites W1991372364 @default.
- W3048397235 cites W1993712652 @default.
- W3048397235 cites W1998274991 @default.
- W3048397235 cites W1999054014 @default.
- W3048397235 cites W2007610579 @default.
- W3048397235 cites W2011559798 @default.
- W3048397235 cites W2018182154 @default.
- W3048397235 cites W2019253664 @default.
- W3048397235 cites W2019317570 @default.
- W3048397235 cites W2021489383 @default.
- W3048397235 cites W2024619217 @default.
- W3048397235 cites W2024809912 @default.
- W3048397235 cites W2024925152 @default.
- W3048397235 cites W2026180657 @default.
- W3048397235 cites W2026854040 @default.
- W3048397235 cites W2030265388 @default.
- W3048397235 cites W2031752322 @default.
- W3048397235 cites W2032867856 @default.
- W3048397235 cites W2042377388 @default.
- W3048397235 cites W2043113536 @default.
- W3048397235 cites W2043204829 @default.
- W3048397235 cites W2044341880 @default.
- W3048397235 cites W2045730105 @default.
- W3048397235 cites W2050166933 @default.
- W3048397235 cites W2051990601 @default.
- W3048397235 cites W2054760729 @default.
- W3048397235 cites W2055245602 @default.
- W3048397235 cites W2057813347 @default.
- W3048397235 cites W2059890964 @default.
- W3048397235 cites W2060393870 @default.
- W3048397235 cites W2066392676 @default.
- W3048397235 cites W2069290637 @default.
- W3048397235 cites W2072415516 @default.
- W3048397235 cites W2083876822 @default.
- W3048397235 cites W2086089050 @default.
- W3048397235 cites W2100591565 @default.
- W3048397235 cites W2105585839 @default.
- W3048397235 cites W2107665433 @default.
- W3048397235 cites W2112250552 @default.
- W3048397235 cites W2115176808 @default.
- W3048397235 cites W2120579640 @default.
- W3048397235 cites W2122740168 @default.
- W3048397235 cites W2122797682 @default.
- W3048397235 cites W2125593966 @default.
- W3048397235 cites W2126525177 @default.
- W3048397235 cites W2131078803 @default.
- W3048397235 cites W2132606465 @default.
- W3048397235 cites W2136468098 @default.
- W3048397235 cites W2143951787 @default.
- W3048397235 cites W2145949861 @default.
- W3048397235 cites W2147238277 @default.
- W3048397235 cites W2150748567 @default.
- W3048397235 cites W2152609353 @default.
- W3048397235 cites W2153094950 @default.
- W3048397235 cites W2160185049 @default.
- W3048397235 cites W2160689761 @default.
- W3048397235 cites W2161948433 @default.
- W3048397235 cites W2162175607 @default.
- W3048397235 cites W2166739815 @default.
- W3048397235 cites W2167383172 @default.
- W3048397235 cites W2168666423 @default.
- W3048397235 cites W2169621456 @default.
- W3048397235 cites W2176189120 @default.
- W3048397235 cites W2180677138 @default.
- W3048397235 cites W2275514878 @default.
- W3048397235 cites W2315538569 @default.
- W3048397235 cites W2339286673 @default.
- W3048397235 cites W2530559766 @default.
- W3048397235 cites W2553534905 @default.
- W3048397235 cites W2599075603 @default.
- W3048397235 cites W2689866037 @default.
- W3048397235 cites W2763904814 @default.
- W3048397235 cites W2786417636 @default.
- W3048397235 cites W2789677566 @default.
- W3048397235 cites W2809060824 @default.
- W3048397235 cites W2886465339 @default.
- W3048397235 cites W2889197569 @default.
- W3048397235 cites W2891255725 @default.
- W3048397235 cites W2895223694 @default.
- W3048397235 cites W2900826101 @default.