FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048402509> ?p ?o ?g. }

• W3048402509 endingPage "e1008760" @default.
• W3048402509 startingPage "e1008760" @default.
• W3048402509 abstract "Influenza A viruses (IAVs) remain a significant global health burden. Activation of the innate immune response is important for controlling early virus replication and spread. It is unclear how early IAV replication events contribute to immune detection. Additionally, while many cell types in the lung can be infected, it is not known if all cell types contribute equally to establish the antiviral state in the host. Here, we use single-cycle influenza A viruses (scIAVs) to characterize the early immune response to IAV in vitro and in vivo. We found that the magnitude of virus replication contributes to antiviral gene expression within infected cells prior to the induction of a global response. We also developed a scIAV that is only capable of undergoing primary transcription, the earliest stage of virus replication. Using this tool, we uncovered replication stage-specific responses in vitro and in vivo. Using several innate immune receptor knockout cell lines, we identify RIG-I as the predominant antiviral detector of primary virus transcription and amplified replication in vitro. Through a Cre-inducible reporter mouse, we used scIAVs expressing Cre-recombinase to characterize cell type-specific responses in vivo. Individual cell types upregulate unique sets of antiviral genes in response to both primary virus transcription and amplified replication. We also identified antiviral genes that are only upregulated in response to direct infection. Altogether, these data offer insight into the early mechanisms of antiviral gene activation during influenza A infection." @default.
• W3048402509 created "2020-08-18" @default.
• W3048402509 creator A5009461787 @default.
• W3048402509 creator A5020323340 @default.
• W3048402509 creator A5027259297 @default.
• W3048402509 creator A5031994519 @default.
• W3048402509 creator A5065131405 @default.
• W3048402509 creator A5070756331 @default.
• W3048402509 creator A5071569500 @default.
• W3048402509 creator A5080217914 @default.
• W3048402509 date "2020-08-13" @default.
• W3048402509 modified "2023-10-05" @default.
• W3048402509 title "Cell type- and replication stage-specific influenza virus responses in vivo" @default.
• W3048402509 cites W1571767222 @default.
• W3048402509 cites W1975614720 @default.
• W3048402509 cites W1979882857 @default.
• W3048402509 cites W1984329728 @default.
• W3048402509 cites W1997876081 @default.
• W3048402509 cites W2006931456 @default.
• W3048402509 cites W2014960200 @default.
• W3048402509 cites W2043349477 @default.
• W3048402509 cites W2048648611 @default.
• W3048402509 cites W2052308758 @default.
• W3048402509 cites W2068881679 @default.
• W3048402509 cites W2069602708 @default.
• W3048402509 cites W2074600973 @default.
• W3048402509 cites W2094323269 @default.
• W3048402509 cites W2112798049 @default.
• W3048402509 cites W2114104545 @default.
• W3048402509 cites W2116054283 @default.
• W3048402509 cites W2116510961 @default.
• W3048402509 cites W2119642187 @default.
• W3048402509 cites W2120791139 @default.
• W3048402509 cites W2130116522 @default.
• W3048402509 cites W2138207763 @default.
• W3048402509 cites W2139090486 @default.
• W3048402509 cites W2148985310 @default.
• W3048402509 cites W2162440799 @default.
• W3048402509 cites W2168629186 @default.
• W3048402509 cites W2170551349 @default.
• W3048402509 cites W2243988213 @default.
• W3048402509 cites W2261974718 @default.
• W3048402509 cites W2326079572 @default.
• W3048402509 cites W2470517214 @default.
• W3048402509 cites W2600175450 @default.
• W3048402509 cites W2759082725 @default.
• W3048402509 cites W2784234398 @default.
• W3048402509 cites W2791142331 @default.
• W3048402509 cites W2801310804 @default.
• W3048402509 cites W2885175320 @default.
• W3048402509 cites W2887886950 @default.
• W3048402509 cites W2891673158 @default.
• W3048402509 cites W2941266954 @default.
• W3048402509 cites W2945865759 @default.
• W3048402509 cites W2948085510 @default.
• W3048402509 cites W2953162568 @default.
• W3048402509 cites W2965529552 @default.
• W3048402509 cites W2965596364 @default.
• W3048402509 cites W2976757604 @default.
• W3048402509 cites W2994710719 @default.
• W3048402509 cites W2996653358 @default.
• W3048402509 cites W2998742227 @default.
• W3048402509 cites W3000988244 @default.
• W3048402509 doi "https://doi.org/10.1371/journal.ppat.1008760" @default.
• W3048402509 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7447048" @default.
• W3048402509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32790753" @default.
• W3048402509 hasPublicationYear "2020" @default.
• W3048402509 type Work @default.
• W3048402509 sameAs 3048402509 @default.
• W3048402509 citedByCount "17" @default.
• W3048402509 countsByYear W30484025092020 @default.
• W3048402509 countsByYear W30484025092021 @default.
• W3048402509 countsByYear W30484025092022 @default.
• W3048402509 countsByYear W30484025092023 @default.
• W3048402509 crossrefType "journal-article" @default.
• W3048402509 hasAuthorship W3048402509A5009461787 @default.
• W3048402509 hasAuthorship W3048402509A5020323340 @default.
• W3048402509 hasAuthorship W3048402509A5027259297 @default.
• W3048402509 hasAuthorship W3048402509A5031994519 @default.
• W3048402509 hasAuthorship W3048402509A5065131405 @default.
• W3048402509 hasAuthorship W3048402509A5070756331 @default.
• W3048402509 hasAuthorship W3048402509A5071569500 @default.
• W3048402509 hasAuthorship W3048402509A5080217914 @default.
• W3048402509 hasBestOaLocation W30484025091 @default.
• W3048402509 hasConcept C136449434 @default.
• W3048402509 hasConcept C140704245 @default.
• W3048402509 hasConcept C159047783 @default.
• W3048402509 hasConcept C203014093 @default.
• W3048402509 hasConcept C2522874641 @default.
• W3048402509 hasConcept C2777546802 @default.
• W3048402509 hasConcept C86803240 @default.
• W3048402509 hasConcept C8891405 @default.
• W3048402509 hasConcept C95444343 @default.
• W3048402509 hasConceptScore W3048402509C136449434 @default.
• W3048402509 hasConceptScore W3048402509C140704245 @default.
• W3048402509 hasConceptScore W3048402509C159047783 @default.
• W3048402509 hasConceptScore W3048402509C203014093 @default.
• W3048402509 hasConceptScore W3048402509C2522874641 @default.

• next