FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048402955> ?p ?o ?g. }

• W3048402955 endingPage "1244" @default.
• W3048402955 startingPage "1234" @default.
• W3048402955 abstract "•Adding Oral T4 for 3 months to HF treatment improves patient functional status. •L-thyroxine helps LV reverse remodeling in IDCM without changing TH levels. •Oral T4 improves cardiac mechanics in circumferential and longitudinal direction. •Short-term T4 can be added safely to HF treatment without adverse effects. Objective Previous experimental studies have provided evidence of notable changes in thyroid hormone signaling that corresponds to alterations in myocardial function in animal models of heart failure (HF). The present study further explores whether oral thyroid hormone treatment can change left ventricular (LV) mechanics and functional status in patients with idiopathic dilated cardiomyopathy (IDCM) or not. Methods Sixty IDCM patients who were receiving conventional HF treatment were randomized to oral L-thyroxine (n = 40) or placebo (n = 20) for 3 months. Fifty-two (86.7%) of all IDCM patients were symptomatic, their mean age was 41 ± 12 years, and their ejection fraction was 32% ± 7%. At baseline, the two groups were comparable in clinical and echocardiographic variables. Vector velocity imaging was utilized to assess LV mechanics. Myocardial longitudinal peak systolic strain, systolic strain rate, early and late diastolic strain rate, circumferential strain, LV dyssynchrony, plasma tri-iodothyronine, thyroxine, and thyroid stimulating hormone levels were measured at baseline and 3 months after treatment. Results All patients receiving L-thyroxine significantly improved in functional status (New York Heart Association class; P < .001) and echocardiographic parameters including end-diastolic diameter (P < .001), end-systolic diameter (P < .001), mitral regurgitation severity reduction (P < .001), and increased ejection fraction (P < .001). Left ventricular mechanics showed marked improvement at segmental and global levels of both longitudinal and circumferential myocardial strain (P < .005) when compared with placebo group. Conclusions Short-term L-thyroxine therapy is well tolerated in IDCM patients. It improves cardiac mechanics and functional status, which might support the potential role of synthetic thyroid hormones in HF treatment. Previous experimental studies have provided evidence of notable changes in thyroid hormone signaling that corresponds to alterations in myocardial function in animal models of heart failure (HF). The present study further explores whether oral thyroid hormone treatment can change left ventricular (LV) mechanics and functional status in patients with idiopathic dilated cardiomyopathy (IDCM) or not. Sixty IDCM patients who were receiving conventional HF treatment were randomized to oral L-thyroxine (n = 40) or placebo (n = 20) for 3 months. Fifty-two (86.7%) of all IDCM patients were symptomatic, their mean age was 41 ± 12 years, and their ejection fraction was 32% ± 7%. At baseline, the two groups were comparable in clinical and echocardiographic variables. Vector velocity imaging was utilized to assess LV mechanics. Myocardial longitudinal peak systolic strain, systolic strain rate, early and late diastolic strain rate, circumferential strain, LV dyssynchrony, plasma tri-iodothyronine, thyroxine, and thyroid stimulating hormone levels were measured at baseline and 3 months after treatment. All patients receiving L-thyroxine significantly improved in functional status (New York Heart Association class; P < .001) and echocardiographic parameters including end-diastolic diameter (P < .001), end-systolic diameter (P < .001), mitral regurgitation severity reduction (P < .001), and increased ejection fraction (P < .001). Left ventricular mechanics showed marked improvement at segmental and global levels of both longitudinal and circumferential myocardial strain (P < .005) when compared with placebo group. Short-term L-thyroxine therapy is well tolerated in IDCM patients. It improves cardiac mechanics and functional status, which might support the potential role of synthetic thyroid hormones in HF treatment." @default.
• W3048402955 created "2020-08-18" @default.
• W3048402955 creator A5011158638 @default.
• W3048402955 creator A5025593137 @default.
• W3048402955 creator A5038546834 @default.
• W3048402955 creator A5077089317 @default.
• W3048402955 creator A5083166628 @default.
• W3048402955 date "2020-10-01" @default.
• W3048402955 modified "2023-10-16" @default.
• W3048402955 title "Effect of Short-Term L-Thyroxine Therapy on Left Ventricular Mechanics in Idiopathic Dilated Cardiomyopathy" @default.
• W3048402955 cites W1920638865 @default.
• W3048402955 cites W1999293962 @default.
• W3048402955 cites W2000333200 @default.
• W3048402955 cites W2031417302 @default.
• W3048402955 cites W2061897374 @default.
• W3048402955 cites W2068486894 @default.
• W3048402955 cites W2085154833 @default.
• W3048402955 cites W2088104087 @default.
• W3048402955 cites W2103384858 @default.
• W3048402955 cites W2107898048 @default.
• W3048402955 cites W2108218509 @default.
• W3048402955 cites W2113900128 @default.
• W3048402955 cites W2121199456 @default.
• W3048402955 cites W2126270248 @default.
• W3048402955 cites W2152156583 @default.
• W3048402955 cites W2152277743 @default.
• W3048402955 cites W2162768237 @default.
• W3048402955 cites W2165336308 @default.
• W3048402955 cites W2289163020 @default.
• W3048402955 cites W2566265692 @default.
• W3048402955 cites W2586488178 @default.
• W3048402955 cites W2595311390 @default.
• W3048402955 cites W2792464922 @default.
• W3048402955 cites W2889905654 @default.
• W3048402955 cites W2980405939 @default.
• W3048402955 cites W2991664926 @default.
• W3048402955 cites W4234374651 @default.
• W3048402955 doi "https://doi.org/10.1016/j.echo.2020.05.009" @default.
• W3048402955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32792320" @default.
• W3048402955 hasPublicationYear "2020" @default.
• W3048402955 type Work @default.
• W3048402955 sameAs 3048402955 @default.
• W3048402955 citedByCount "10" @default.
• W3048402955 countsByYear W30484029552021 @default.
• W3048402955 countsByYear W30484029552022 @default.
• W3048402955 countsByYear W30484029552023 @default.
• W3048402955 crossrefType "journal-article" @default.
• W3048402955 hasAuthorship W3048402955A5011158638 @default.
• W3048402955 hasAuthorship W3048402955A5025593137 @default.
• W3048402955 hasAuthorship W3048402955A5038546834 @default.
• W3048402955 hasAuthorship W3048402955A5077089317 @default.
• W3048402955 hasAuthorship W3048402955A5083166628 @default.
• W3048402955 hasConcept C126322002 @default.
• W3048402955 hasConcept C142724271 @default.
• W3048402955 hasConcept C164705383 @default.
• W3048402955 hasConcept C204787440 @default.
• W3048402955 hasConcept C27081682 @default.
• W3048402955 hasConcept C2776383484 @default.
• W3048402955 hasConcept C2778198053 @default.
• W3048402955 hasConcept C2778797674 @default.
• W3048402955 hasConcept C2909944400 @default.
• W3048402955 hasConcept C526584372 @default.
• W3048402955 hasConcept C57900726 @default.
• W3048402955 hasConcept C71924100 @default.
• W3048402955 hasConcept C78085059 @default.
• W3048402955 hasConcept C84393581 @default.
• W3048402955 hasConceptScore W3048402955C126322002 @default.
• W3048402955 hasConceptScore W3048402955C142724271 @default.
• W3048402955 hasConceptScore W3048402955C164705383 @default.
• W3048402955 hasConceptScore W3048402955C204787440 @default.
• W3048402955 hasConceptScore W3048402955C27081682 @default.
• W3048402955 hasConceptScore W3048402955C2776383484 @default.
• W3048402955 hasConceptScore W3048402955C2778198053 @default.
• W3048402955 hasConceptScore W3048402955C2778797674 @default.
• W3048402955 hasConceptScore W3048402955C2909944400 @default.
• W3048402955 hasConceptScore W3048402955C526584372 @default.
• W3048402955 hasConceptScore W3048402955C57900726 @default.
• W3048402955 hasConceptScore W3048402955C71924100 @default.
• W3048402955 hasConceptScore W3048402955C78085059 @default.
• W3048402955 hasConceptScore W3048402955C84393581 @default.
• W3048402955 hasIssue "10" @default.
• W3048402955 hasLocation W30484029551 @default.
• W3048402955 hasOpenAccess W3048402955 @default.
• W3048402955 hasPrimaryLocation W30484029551 @default.
• W3048402955 hasRelatedWork W117693532 @default.
• W3048402955 hasRelatedWork W1970087856 @default.
• W3048402955 hasRelatedWork W2011390101 @default.
• W3048402955 hasRelatedWork W2033290381 @default.
• W3048402955 hasRelatedWork W2072634555 @default.
• W3048402955 hasRelatedWork W2319905926 @default.
• W3048402955 hasRelatedWork W2354420004 @default.
• W3048402955 hasRelatedWork W2736679304 @default.
• W3048402955 hasRelatedWork W4233925783 @default.
• W3048402955 hasRelatedWork W2266274717 @default.
• W3048402955 hasVolume "33" @default.
• W3048402955 isParatext "false" @default.
• W3048402955 isRetracted "false" @default.
• W3048402955 magId "3048402955" @default.

• next