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• W3048404543 endingPage "1749" @default.
• W3048404543 startingPage "1732" @default.
• W3048404543 abstract "Abstract Objectives MicroRNAs (miRNAs) are a type of small noncoding RNA employed by the cells for gene regulation. A single miRNA, typically 22 nucleotides in length, can regulate the expression of numerous genes. Over the past decade, the study of miRNA biology in the context of cancer has led to the development of new diagnostic and therapeutic opportunities. Key findings MicroRNA dysregulation is commonly associated with cancer, in part because miRNAs are actively involved in the mechanisms like genomic instabilities, aberrant transcriptional control, altered epigenetic regulation and biogenesis machinery defects. MicroRNAs can regulate oncogenes or tumour suppressor genes and thus when altered can lead to tumorigenesis. Expression profiling of miRNAs has boosted the possibilities of application of miRNAs as potential cancer biomarkers and therapeutic targets, although the feasibility of these approaches will require further validation. Summary In this review, we will focus on how miRNAs regulate tumour development and the potential applications of targeting miRNAs for cancer therapy." @default.
• W3048404543 created "2020-08-18" @default.
• W3048404543 creator A5033285614 @default.
• W3048404543 creator A5051236934 @default.
• W3048404543 date "2020-08-12" @default.
• W3048404543 modified "2023-09-30" @default.
• W3048404543 title "Recent trends in targeting miRNAs for cancer therapy" @default.
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