FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048405744> ?p ?o ?g. }

• W3048405744 abstract "Abstract Background The current paradigm for treating toddler’s diarrhea comprises dietary modification and fluid restriction. Previous studies show that probiotics and proton-pump inhibitors (PPIs) or H 2 blockers could control diarrhea associated with functional gastrointestinal disorders (FGIDs). This study aims to determine and compare the efficacy of a short course of oral ranitidine and a probiotic in the treatment of toddler’s diarrhea. Methods This study was a parallel-group randomized controlled trial (RCT). We sequentially enrolled 40 patients who met the eligibility criteria. We randomly assigned 20 patients to the oral ranitidine group, ten patients to the probiotic group, and ten patients to the placebo group. In the oral ranitidine group, patients received oral ranitidine (3 mg/kg/day) once daily for 10 days; in the probiotic and placebo groups, they were administered 5 to 10 billion colony-forming units (CFUs) per day of lyophilized Lactobacillus rhamnosus and 50 mg of once-daily oral vitamin C tablet respectively for 10 days. Stool frequency and consistency on the 10th day of the interventions were recorded as the primary outcomes. We used the Student’s t-test to determine if there were significant differences in the mean daily stool frequencies in the three intervention groups. A p -value < 0.05 was adopted as the level of statistical significance. Results In the ranitidine group, stool frequency decreased significantly from an average of five per day on the first day to an average of approximately one per day on the 10th day of intervention (t = 10.462, p < 0.001). Additionally, stool consistency normalized on the 10th day of intervention. In the probiotic group, there was a significant reduction in stool frequency from an average of five per day on the first day to four per day on the 10th day (t = 2.586, p = 0.041), although stool consistency remained loose. However, stool consistency and frequency were not significantly affected in the placebo group (t = 1.964, p = 0.072). Conclusion Oral ranitidine is more effective than probiotics in reducing stool frequency and normalizing stool consistency in toddler’s diarrhea. We recommend multi-center trials with appropriate study designs to confirm and validate this finding. Trial registration ISRCTN, ISRCTN10783996 . Registered 8 April 2016-Registered retrospectively." @default.
• W3048405744 created "2020-08-18" @default.
• W3048405744 creator A5006519308 @default.
• W3048405744 creator A5031476801 @default.
• W3048405744 creator A5048378906 @default.
• W3048405744 creator A5051614095 @default.
• W3048405744 creator A5075465398 @default.
• W3048405744 date "2020-08-11" @default.
• W3048405744 modified "2023-10-10" @default.
• W3048405744 title "A short course of oral ranitidine as a novel treatment for toddler’s diarrhea: a parallel-group randomized controlled trial" @default.
• W3048405744 cites W1580497498 @default.
• W3048405744 cites W1967079297 @default.
• W3048405744 cites W1972730317 @default.
• W3048405744 cites W1981738430 @default.
• W3048405744 cites W1986963520 @default.
• W3048405744 cites W2002625639 @default.
• W3048405744 cites W2013446759 @default.
• W3048405744 cites W2017242867 @default.
• W3048405744 cites W2027955126 @default.
• W3048405744 cites W2029073712 @default.
• W3048405744 cites W2033573730 @default.
• W3048405744 cites W2035467833 @default.
• W3048405744 cites W2058300586 @default.
• W3048405744 cites W2060575412 @default.
• W3048405744 cites W2061305821 @default.
• W3048405744 cites W2074183778 @default.
• W3048405744 cites W2085039414 @default.
• W3048405744 cites W2106744168 @default.
• W3048405744 cites W2109875954 @default.
• W3048405744 cites W2129997920 @default.
• W3048405744 cites W2135988849 @default.
• W3048405744 cites W2137207669 @default.
• W3048405744 cites W2137645401 @default.
• W3048405744 cites W2139237256 @default.
• W3048405744 cites W2155766188 @default.
• W3048405744 cites W2156286274 @default.
• W3048405744 cites W2171712530 @default.
• W3048405744 cites W2286517910 @default.
• W3048405744 cites W2333169722 @default.
• W3048405744 cites W2460154828 @default.
• W3048405744 cites W1510824625 @default.
• W3048405744 cites W2126652554 @default.
• W3048405744 doi "https://doi.org/10.1186/s12887-020-02267-7" @default.
• W3048405744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7422520" @default.
• W3048405744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32781992" @default.
• W3048405744 hasPublicationYear "2020" @default.
• W3048405744 type Work @default.
• W3048405744 sameAs 3048405744 @default.
• W3048405744 citedByCount "1" @default.
• W3048405744 countsByYear W30484057442021 @default.
• W3048405744 crossrefType "journal-article" @default.
• W3048405744 hasAuthorship W3048405744A5006519308 @default.
• W3048405744 hasAuthorship W3048405744A5031476801 @default.
• W3048405744 hasAuthorship W3048405744A5048378906 @default.
• W3048405744 hasAuthorship W3048405744A5051614095 @default.
• W3048405744 hasAuthorship W3048405744A5075465398 @default.
• W3048405744 hasBestOaLocation W30484057441 @default.
• W3048405744 hasConcept C126322002 @default.
• W3048405744 hasConcept C138496976 @default.
• W3048405744 hasConcept C142724271 @default.
• W3048405744 hasConcept C15744967 @default.
• W3048405744 hasConcept C168563851 @default.
• W3048405744 hasConcept C197934379 @default.
• W3048405744 hasConcept C204787440 @default.
• W3048405744 hasConcept C27081682 @default.
• W3048405744 hasConcept C2776651480 @default.
• W3048405744 hasConcept C2777445857 @default.
• W3048405744 hasConcept C2778242525 @default.
• W3048405744 hasConcept C2779802037 @default.
• W3048405744 hasConcept C2780255968 @default.
• W3048405744 hasConcept C523546767 @default.
• W3048405744 hasConcept C54355233 @default.
• W3048405744 hasConcept C71924100 @default.
• W3048405744 hasConcept C86803240 @default.
• W3048405744 hasConcept C90924648 @default.
• W3048405744 hasConceptScore W3048405744C126322002 @default.
• W3048405744 hasConceptScore W3048405744C138496976 @default.
• W3048405744 hasConceptScore W3048405744C142724271 @default.
• W3048405744 hasConceptScore W3048405744C15744967 @default.
• W3048405744 hasConceptScore W3048405744C168563851 @default.
• W3048405744 hasConceptScore W3048405744C197934379 @default.
• W3048405744 hasConceptScore W3048405744C204787440 @default.
• W3048405744 hasConceptScore W3048405744C27081682 @default.
• W3048405744 hasConceptScore W3048405744C2776651480 @default.
• W3048405744 hasConceptScore W3048405744C2777445857 @default.
• W3048405744 hasConceptScore W3048405744C2778242525 @default.
• W3048405744 hasConceptScore W3048405744C2779802037 @default.
• W3048405744 hasConceptScore W3048405744C2780255968 @default.
• W3048405744 hasConceptScore W3048405744C523546767 @default.
• W3048405744 hasConceptScore W3048405744C54355233 @default.
• W3048405744 hasConceptScore W3048405744C71924100 @default.
• W3048405744 hasConceptScore W3048405744C86803240 @default.
• W3048405744 hasConceptScore W3048405744C90924648 @default.
• W3048405744 hasIssue "1" @default.
• W3048405744 hasLocation W30484057441 @default.
• W3048405744 hasLocation W30484057442 @default.
• W3048405744 hasLocation W30484057443 @default.
• W3048405744 hasOpenAccess W3048405744 @default.
• W3048405744 hasPrimaryLocation W30484057441 @default.
• W3048405744 hasRelatedWork W1824156481 @default.

• next