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- W3048406670 abstract "Last year was a busy one for the US Food and Drug Administration. Drug approvals hit an all-time high, with 59 new molecular entities securing the agency’s permission to head to market. Small molecules continue to account for the lion’s share of new drugs, composing 64% of therapies approved in 2018. Antibodies represented 20% of approvals. But with the remaining new drugs falling outside those two main modalities, the list also reflects the increasingly diverse approaches researchers are using to take down diseases—particularly rare, genetic diseases. Indeed, one of the highlights of the year was the approval of Alnylam Pharmaceuticals’ Onpattro, the first drug that acts by RNA interference. Onpattro uses short, double-stranded nucleotides to intercept messenger RNA before it can deliver the instructions for the assembly of an unwanted protein. It was a scientific achievement, but the commercial viability of the product—and RNAi technology more generally—remains to be seen." @default.
- W3048406670 created "2020-08-18" @default.
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- W3048406670 date "2019-01-07" @default.
- W3048406670 modified "2023-10-16" @default.
- W3048406670 title "New drug approvals hit an all-time high" @default.
- W3048406670 doi "https://doi.org/10.1021/cen-09701-buscon4" @default.
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