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- W3048425984 abstract "Isoniazid, the choice antitubercular agent, has only been employed against Mycobacterium tuberculosis. This study evaluated if the enzyme-mimetic activities of magnetic nanoparticles could accelerate the activation process of isoniazid against mycobacterial and, more importantly, non-mycobacterial microorganisms. First, magnetic nanoparticles were synthesized and coated by lipoamino acid; then, isoniazid was conjugated to synthesized nanoparticles. Antibacterial activities of nanoconjugated isoniazid were evaluated against Mycobacterium tuberculosis and four Gram-positive and Gram-negative nonmycobacterial strains through a microdilution broth process. Results showed that the required amount of isoniazid against Mycobacterium tuberculosis would decrease to 44.8% and 16.7% in conjugation with naked and surface-modified magnetic nanoparticles, respectively. Also, 32 μ g/mL and 38 μ g/mL of isoniazid in conjugation with naked and surface-modified nanoparticles, respectively, could prevent the growth of Enterococcus faecalis , Escherichia coli , Pseudomonas aeruginosa , and Staphylococcus aureus . Hence, the vicinity of magnetic nanoparticles with isoniazid could declare promising aspects of isoniazid antibacterial capabilities." @default.
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- W3048425984 date "2020-08-11" @default.
- W3048425984 modified "2023-09-24" @default.
- W3048425984 title "Antimicrobial Activity of Isoniazid in Conjugation with Surface-Modified Magnetic Nanoparticles against <i>Mycobacterium tuberculosis</i> and Nonmycobacterial Microorganisms" @default.
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- W3048425984 doi "https://doi.org/10.1155/2020/7372531" @default.
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