FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048439331> ?p ?o ?g. }

• W3048439331 abstract "Abstract Background Sepsis induces pulmonary P2X 7 receptor (P2X 7 R) expression and P2X 7 R‐knockout reduced lung inflammation in mice. The present study investigated the expression of circular RNA (circRNA) and mRNA in sepsis‐induced acute lung injury (ALI) treated with a P2X 7 R antagonist. Methods Sepsis was induced by tracheal administration of lipopolysaccharide (LPS), and the mice were then divided into two groups: without [sepsis + dimethyl sulfoxide (DMSO)] or with P2X 7 R antagonist treatment (sepsis + P2X 7 A). Sham mice were administrated sterile normal saline. Serum levels of interleukin (IL)‐1β and tumor necrosis factor (TNF)‐α, pathological changes, cell apoptosis and P2X 7 R expression in lung were assessed, followed by RNA sequencing (RNA‐seq) and bioinformatics analyses. A quantitative reverse transcriptase‐polymerase chain reaction (RT‐qPCR) was used to validate circRNAs and mRNAs. Results Compared to the sham group, LPS‐induced sepsis produced obvious pathological changes in lung tissue, as well as increased apoptotic lung cells, serum TNF‐α and IL‐1β levels, and P2X 7 R expression; P2X 7 R antagonism significantly ameliorated these changes. RNA‐seq identified many dysregulated circRNAs and mRNAs during sepsis, whereas this changed with P2X 7 R antagonism. RT‐qPCR confirmed that Mus musculus (mmu)_circ_0001679, mmu_circ_0001212, phospholamban (Pln), cadherin‐2 (Cdh2) and nitrogen permease regulator 3‐like (Nprl3) expression were significantly increased in the sepsis + DMSO group compared to that in the sham group but were decreased in the sepsis + P2X 7 A group compared to that in the sepsis + DMSO group. The circRNA–microRNA–mRNA coexpression network indicated that mmu_circ_0001679 may regulate Nprl3 and that mmu_circ_0001212 may similarly regulate Pln, Cdh2 and Nprl3 as a competing endogenous RNA. Conclusions P2X 7 R antagonism attenuates sepsis‐induced ALI by inhibiting dysregulated expression of circRNA (circ_0001679, circ_0001212) and mRNA (Pln, Cdh2 and Nprl3)." @default.
• W3048439331 created "2020-08-18" @default.
• W3048439331 creator A5006594480 @default.
• W3048439331 creator A5018631856 @default.
• W3048439331 creator A5031682845 @default.
• W3048439331 creator A5046968551 @default.
• W3048439331 creator A5048198282 @default.
• W3048439331 creator A5061674389 @default.
• W3048439331 creator A5065243448 @default.
• W3048439331 creator A5091516000 @default.
• W3048439331 date "2020-09-30" @default.
• W3048439331 modified "2023-10-10" @default.
• W3048439331 title "Protective effects of P2X7R antagonist in sepsis‐induced acute lung injury in mice via regulation of circ_0001679 and circ_0001212 and downstream Pln, Cdh2, and Nprl3 expression" @default.
• W3048439331 cites W1990077068 @default.
• W3048439331 cites W1990809029 @default.
• W3048439331 cites W1998196970 @default.
• W3048439331 cites W2017977457 @default.
• W3048439331 cites W2036572641 @default.
• W3048439331 cites W2058835062 @default.
• W3048439331 cites W2069214918 @default.
• W3048439331 cites W2080328983 @default.
• W3048439331 cites W2094517081 @default.
• W3048439331 cites W2125498567 @default.
• W3048439331 cites W2256438016 @default.
• W3048439331 cites W2259300587 @default.
• W3048439331 cites W2272187389 @default.
• W3048439331 cites W2280404143 @default.
• W3048439331 cites W2285341304 @default.
• W3048439331 cites W2396198192 @default.
• W3048439331 cites W2617660471 @default.
• W3048439331 cites W2620241325 @default.
• W3048439331 cites W2623552909 @default.
• W3048439331 cites W2678510013 @default.
• W3048439331 cites W2792578653 @default.
• W3048439331 cites W2793081197 @default.
• W3048439331 cites W2793479725 @default.
• W3048439331 cites W2797650369 @default.
• W3048439331 cites W2800965087 @default.
• W3048439331 cites W2806199925 @default.
• W3048439331 cites W2808327635 @default.
• W3048439331 cites W2897587457 @default.
• W3048439331 cites W2936299271 @default.
• W3048439331 cites W2938310628 @default.
• W3048439331 cites W2940765082 @default.
• W3048439331 cites W2946327189 @default.
• W3048439331 cites W2952125019 @default.
• W3048439331 cites W2964015924 @default.
• W3048439331 cites W2967247671 @default.
• W3048439331 cites W2971225283 @default.
• W3048439331 cites W3006241683 @default.
• W3048439331 doi "https://doi.org/10.1002/jgm.3261" @default.
• W3048439331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32783373" @default.
• W3048439331 hasPublicationYear "2020" @default.
• W3048439331 type Work @default.
• W3048439331 sameAs 3048439331 @default.
• W3048439331 citedByCount "23" @default.
• W3048439331 countsByYear W30484393312021 @default.
• W3048439331 countsByYear W30484393312022 @default.
• W3048439331 countsByYear W30484393312023 @default.
• W3048439331 crossrefType "journal-article" @default.
• W3048439331 hasAuthorship W3048439331A5006594480 @default.
• W3048439331 hasAuthorship W3048439331A5018631856 @default.
• W3048439331 hasAuthorship W3048439331A5031682845 @default.
• W3048439331 hasAuthorship W3048439331A5046968551 @default.
• W3048439331 hasAuthorship W3048439331A5048198282 @default.
• W3048439331 hasAuthorship W3048439331A5061674389 @default.
• W3048439331 hasAuthorship W3048439331A5065243448 @default.
• W3048439331 hasAuthorship W3048439331A5091516000 @default.
• W3048439331 hasConcept C126322002 @default.
• W3048439331 hasConcept C170493617 @default.
• W3048439331 hasConcept C17991360 @default.
• W3048439331 hasConcept C185592680 @default.
• W3048439331 hasConcept C203014093 @default.
• W3048439331 hasConcept C2776885963 @default.
• W3048439331 hasConcept C2777714996 @default.
• W3048439331 hasConcept C2778384902 @default.
• W3048439331 hasConcept C2778754761 @default.
• W3048439331 hasConcept C71924100 @default.
• W3048439331 hasConcept C86803240 @default.
• W3048439331 hasConcept C98274493 @default.
• W3048439331 hasConceptScore W3048439331C126322002 @default.
• W3048439331 hasConceptScore W3048439331C170493617 @default.
• W3048439331 hasConceptScore W3048439331C17991360 @default.
• W3048439331 hasConceptScore W3048439331C185592680 @default.
• W3048439331 hasConceptScore W3048439331C203014093 @default.
• W3048439331 hasConceptScore W3048439331C2776885963 @default.
• W3048439331 hasConceptScore W3048439331C2777714996 @default.
• W3048439331 hasConceptScore W3048439331C2778384902 @default.
• W3048439331 hasConceptScore W3048439331C2778754761 @default.
• W3048439331 hasConceptScore W3048439331C71924100 @default.
• W3048439331 hasConceptScore W3048439331C86803240 @default.
• W3048439331 hasConceptScore W3048439331C98274493 @default.
• W3048439331 hasIssue "12" @default.
• W3048439331 hasLocation W30484393311 @default.
• W3048439331 hasOpenAccess W3048439331 @default.
• W3048439331 hasPrimaryLocation W30484393311 @default.
• W3048439331 hasRelatedWork W1874298992 @default.
• W3048439331 hasRelatedWork W2044718664 @default.
• W3048439331 hasRelatedWork W2073275833 @default.
• W3048439331 hasRelatedWork W2127733257 @default.

• next