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• W3048440081 endingPage "e0236991" @default.
• W3048440081 startingPage "e0236991" @default.
• W3048440081 abstract "Disruption of circadian rhythms and variations in the FTO gene may interfere with energy homeostasis and play a role in the development of obesity. The current study assessed the association of common polymorphisms in the CLOCK and FTO genes with standardized body mass index scores (BMI z-scores) and their potential modification of the impact of a culinary nutrition and physical activity intervention in school-age children. Anthropometric measurements were collected in 121 children at the baseline and one-year follow-up of a controlled trial of a school-based culinary nutrition and physical activity intervention. Genotypes of the CLOCK polymorphism (rs1801260) and the FTO polymorphism (rs9939609) were obtained from buccal swabs. Linear mixed-effects regression was applied to evaluate the genetic association and adjust for clusters within families and schools. In our participants, obesity affected 6.6% (8/121) of the children at the baseline and 6.4% (7/109) of the children at the follow-up. The associations between the age- and sex-adjusted BMI z-scores and the two polymorphisms did not reach statistically significance. Yet, sex potentially modified the association between rs1801260 and BMI z-scores. In girls, the G allele carriers had a higher BMI z-scores at the baseline and the follow-up. These polymorphisms did not modify the effect of our culinary nutrition and physical activity intervention on BMI z-scores. Sex is a potential modifier for the association between the CLOCK polymorphism, rs1801260, and BMI z-scores in school-age children. Further investigation is warranted to delineate the sex-dependent role of the CLOCK polymorphisms in the development of childhood obesity." @default.
• W3048440081 created "2020-08-18" @default.
• W3048440081 creator A5010913181 @default.
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• W3048440081 date "2020-08-12" @default.
• W3048440081 modified "2023-10-12" @default.
• W3048440081 title "Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children" @default.
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• W3048440081 doi "https://doi.org/10.1371/journal.pone.0236991" @default.
• W3048440081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7423126" @default.
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• W3048440081 hasPublicationYear "2020" @default.
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